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The map label for this gene is pgk [H]

Identifier: 148827719

GI number: 148827719

Start: 1074656

End: 1075876

Strand: Reverse

Name: pgk [H]

Synonym: CGSHiGG_05890

Alternate gene names: 148827719

Gene position: 1075876-1074656 (Counterclockwise)

Preceding gene: 148827720

Following gene: 148827717

Centisome position: 57.01

GC content: 40.7

Gene sequence:

>1221_bases
ATGCTAAAAAACAAAACTTTTGGGAGTGCGCTGATTATTGCAGGCACAACCATTGGAGCAGGTATGCTTGCTATGCCGCT
TACATCAGCGGGTATGAGCTTTGGTTATACCGTGTTATTGCTCGTTGGCTTGTGGGCTTTGTTGGTTTACAGCGGATTGT
TGTTTGTAGAAGTGTATCAAACAGCGGATCAGTTGGATGATGGTGTCGCCACGCTCGCTGAAAAATATTTTGGGGTTCCT
GGGCGAATTTTCGCCACGTTGAGTTTGTTAGTTTTACTTTATGCACTTTCAGCCGCTTATATTACTGGTGGTGGATCTTT
ACTTTCAGGCTTGCCAACGGCTTTTGGAATGGACGCAATCTCACTTAAAACGGCGATTATTATCTTTACTGTTGTATTAG
GTTCTTTCGTGGTTGTAGGAACGAAAGGCGTGGATGGCTTAACTCGCGTGTTATTTATTGGTAAGTTAATCGCCTTTGCT
TTTGTGCTGTTTATGATGCTTCCAAAAGTAGCAACAGATAATTTAATGGCATTGCCTTTGGATTATGCTTTTGTGGTTTC
TGCGGCACCAATATTTTTTACTTCTTTCGGTTTCCACGTTATTATGGCGAGTGTGAATAGCTACTTAGGTGGAAGTGTTG
ATAAATTTCGTCGTGCCATTTTGATTGGTACTGCGATTCCATTAGCCGCTTACCTTGTATGGCAGTTAGCAACTCATGGT
GTATTAAGTCAAAGTGAATTTGTGCGTATTTTACAAGCTGACCCAACGCTAAATGGCTTAGTGAATGCAACGCGTGAAAT
TACAGGTTCTCATTTTATGGGAGAGGTTGTGCGTGTGTTTTCATCACTTGCACTGATCACTTCTTTCTTAGGCGTAATGC
TTGGTGTATTTGAGGGATTGGGTGATTTATTCAAACGCTATCATTTGCCAAATAATCGCTTTGTTTTAACTGTAGTCGCA
TTTTTACCGCCACTTGTATTTGCATTATTTTATCCTGAAGGATTTATTACTGCATTAAGTTACGCAGGTTTATTGTGTGC
GTTCTATTGCTTAATTTTACCAATTGGTTTGGCATGGCGTACACGTATTGAAAATCCAACATTGCCATATCGTGTTTCTG
GCGGTAATTTCGCTTTGGTGTTTGCGTTATTAATTGGCGTCGTGATTATGCTCATTCCATTTTTAATTCAATGGGGATAT
TTACCAGTGGTGGCGGGGTAA

Upstream 100 bases:

>100_bases
AGGCAATGATTCTTATCTTTCTGTTTGCCGTTTACACTATAAAGAAAAGTGCGGTCAAATTTAAATTAGTTTTTAAACAC
AACATTATAAGGACAATTTT

Downstream 100 bases:

>100_bases
TATTTGATTTTTCCCTAGAGAAAACACTTTTCTTCCTCTGTTTGCAGGGGAGCTGCCGAAGGTTGAGGGGAGATATAGAA
AGCCCCTTCCGTCCTTCGGG

Product: phosphoglycerate kinase

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 2 [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMSFGYTVLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGVP
GRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAISLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTVVA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWRTRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGY
LPVVAG

Sequences:

>Translated_406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMSFGYTVLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGVP
GRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAISLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTVVA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWRTRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGY
LPVVAG
>Mature_406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMSFGYTVLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGVP
GRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAISLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTVVA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWRTRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGY
LPVVAG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=46.1538461538462, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1790145, Length=402, Percent_Identity=28.8557213930348, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789552, Length=389, Percent_Identity=28.2776349614396, Blast_Score=137, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43529; Mature: 43529

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMSFGYTVLLLVGLWALLVYSGLLFVEVYQ
CCCCCCCCCEEEEECCHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TADQLDDGVATLAEKYFGVPGRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHCCHHH
SLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFAFVLFMMLPKVATDNLMALPL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
DYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLFKRYHLPNNRFVLTVVAFLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGYLPVVAG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMSFGYTVLLLVGLWALLVYSGLLFVEVYQ
CCCCCCCCCEEEEECCHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TADQLDDGVATLAEKYFGVPGRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHCCHHH
SLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFAFVLFMMLPKVATDNLMALPL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
DYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLFKRYHLPNNRFVLTVVAFLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGYLPVVAG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]