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The map label for this gene is hisC1 [H]

Identifier: 148827668

GI number: 148827668

Start: 1019283

End: 1020341

Strand: Direct

Name: hisC1 [H]

Synonym: CGSHiGG_05595

Alternate gene names: 148827668

Gene position: 1019283-1020341 (Clockwise)

Preceding gene: 148827667

Following gene: 148827669

Centisome position: 54.01

GC content: 41.27

Gene sequence:

>1059_bases
ATGACAATCACAACTTTATCCCGACAAAATATACAAGCCTTAACGCCATATCAATCCGCTCGAAAACTCGGCGGCAATGG
TACGATTTGGCTGAATGCAAATGAATATCCAACCTCGCCTGAATTTCAGCTTTCGGGTAAGGATTTAAACCGCTACCCCG
AACCTCAGCCTCAAAGAGTGGTACAGGCTTATGCGAATTATGCGGGCGTTTCAACTGAAAATGTACTCGTTACTCGTGGC
GGTGATGAAGGCATTGAATTGATAATCCACACTTTTTGCGAACCCAAACAAGATGCCATTTTATTCTGTCCTCCGACTTA
CGGAATGTATGCAGTGAGTGCTGAAACGGCAGGTGTGCTAAGTAAGACCGTGCCTTTAACTGACGATTTTCAGCTTAATT
TGCCAGAAATCAAAAATCATCTTAATGATGTAAAAGTAGTCTTTGTATGCAGCCCAAATAATCCGACAGGTAATTTGCTC
AAGCAATCAGATATACTCGATCTTTTGCAAATCACGGCAGGCAAAGCGATTGTGGTGGTGGACGAAGCCTATATTGAGTT
CTGTCCTGAAGCAAGCGTTATTAATTTGCTTAAAAATTACCCGCACTTAGCAATTATCCGCACACTCTCTAAAGCCTTTG
CTTTAGCTGGATTGCGTTGTGGTTTTGTGTTAGCAAACCCTGAGCTAATTGACATCTTAAGTAAGGTAATCGCTCCATAT
CCTATCCCTGTGCCAAGTGCTGATCTTGCGGAACAAGCGTTAAGACCTGCGAACATCGCCACTGTTCAAGCTCTCACACA
AGAACTTCTTTCCAATCGTCAATGGCTTGCTAAAGCTCTTTTAGTTTTACATCAAGTGGAAAAAGTGTATGAAAGTGAAG
CTAATTATCTGTTGATCAAATGTCAAAACGGGCAAGCTGTGTTTAAGGCATTGTGGGAACAAGGAATTATTTTAAGAGAC
CAGAATAAGACATTGCATTTACAAAATTGTATTCGCATTACTGTGGGAACAAGGAATGAGTGTGAGAAAGTTGTTGAAGC
AATTAAGGAGGTAAAATGA

Upstream 100 bases:

>100_bases
GATCTAAGCACGACACGTAAGCTGTCAAATTTTCATACAACAATACGAAATATGTATGAATGATTACAATTCGCACATTT
TACAATGGAAGAAAACAATA

Downstream 100 bases:

>100_bases
ACCACCTCCTATTTAAGTCACAGAGCGATTCGAGATTATTTAGTTTTATACTGTTTGTATAAAGCAAATGATAAACCTCA
TACCATTCATATAACATACA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRVVQAYANYAGVSTENVLVTRG
GDEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVLSKTVPLTDDFQLNLPEIKNHLNDVKVVFVCSPNNPTGNLL
KQSDILDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLANPELIDILSKVIAPY
PIPVPSADLAEQALRPANIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIKCQNGQAVFKALWEQGIILRD
QNKTLHLQNCIRITVGTRNECEKVVEAIKEVK

Sequences:

>Translated_352_residues
MTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRVVQAYANYAGVSTENVLVTRG
GDEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVLSKTVPLTDDFQLNLPEIKNHLNDVKVVFVCSPNNPTGNLL
KQSDILDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLANPELIDILSKVIAPY
PIPVPSADLAEQALRPANIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIKCQNGQAVFKALWEQGIILRD
QNKTLHLQNCIRITVGTRNECEKVVEAIKEVK
>Mature_351_residues
TITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRVVQAYANYAGVSTENVLVTRGG
DEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVLSKTVPLTDDFQLNLPEIKNHLNDVKVVFVCSPNNPTGNLLK
QSDILDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLANPELIDILSKVIAPYP
IPVPSADLAEQALRPANIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIKCQNGQAVFKALWEQGIILRDQ
NKTLHLQNCIRITVGTRNECEKVVEAIKEVK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=349, Percent_Identity=60.7449856733524, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322075, Length=371, Percent_Identity=35.5795148247978, Blast_Score=184, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38905; Mature: 38774

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRV
CEEEECCCCCCEEECCHHHHHHCCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHH
VQAYANYAGVSTENVLVTRGGDEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVL
HHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEECHHHHHH
SKTVPLTDDFQLNLPEIKNHLNDVKVVFVCSPNNPTGNLLKQSDILDLLQITAGKAIVVV
HCCCCCCCCCEECCHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
DEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLANPELIDILSKVIAPY
EHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCC
PIPVPSADLAEQALRPANIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIK
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
CQNGQAVFKALWEQGIILRDQNKTLHLQNCIRITVGTRNECEKVVEAIKEVK
ECCCHHHHHHHHHCCCEEECCCCEEEECCEEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRV
EEEECCCCCCEEECCHHHHHHCCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHH
VQAYANYAGVSTENVLVTRGGDEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVL
HHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEECHHHHHH
SKTVPLTDDFQLNLPEIKNHLNDVKVVFVCSPNNPTGNLLKQSDILDLLQITAGKAIVVV
HCCCCCCCCCEECCHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
DEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLANPELIDILSKVIAPY
EHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCC
PIPVPSADLAEQALRPANIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIK
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
CQNGQAVFKALWEQGIILRDQNKTLHLQNCIRITVGTRNECEKVVEAIKEVK
ECCCHHHHHHHHHCCCEEECCCCEEEECCEEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]