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The map label for this gene is hisB [H]

Identifier: 148827669

GI number: 148827669

Start: 1020453

End: 1021541

Strand: Direct

Name: hisB [H]

Synonym: CGSHiGG_05600

Alternate gene names: 148827669

Gene position: 1020453-1021541 (Clockwise)

Preceding gene: 148827668

Following gene: 148827670

Centisome position: 54.07

GC content: 40.5

Gene sequence:

>1089_bases
ATGCAACCTACTCTTTTTATCGACCGAGACGGCACATTAATTGATGAACCAAAAACTGATTTCCAAATTGACAGTTTAGA
GAAACTAAAATTAGAACCGAAAGTGATTCCCGCACTCCTCAGACTGAAAGCGAAATACCGTTTTGTGATAGTTTCTAATC
AAGATGGGCTTGGTACGGATGCTTTTCCGCAAACAAATTTTGATAAGCCCCACAATGTAATGATGGCATTATTTGAATCT
CAGGGCATTACCTTTGATGAAGTACTCATTTGCCCGCATAAGCCCGAAGAAAATTGTCTATGTCGCAAACCAAAAATTAA
GTTGCTTGATCACTATATTCGTAAAAATTTATTCGATATTGACCGCTCTTTTGTCATTGGTGACCGAGAGACCGATATGC
AATTAGCAGAAAATCTAGGTATTCGAGCTATTCAATACGATCCACAGAAAATGAATTGGGATCTGATTGCAGAAAAATTG
TTGGGGGAAACGGTCACAAACTGTGGCAAACGTCCGCCACGTTTTGCAGAAGTAATTCGTCAAACTAAAGAGACCGATAT
TAAAGTGCAGGTTTGGCTAGATGAAGCTGGTGTAAATGAAATCAAAACCGGCGTTGGTTTTTTTGACCATATGCTCGATC
AAATCGCCACACACGGTGGGTTTAGAATGAACGTGCAGTGTAAAGGCGATTTATGGATTGACGAACATCACACGGTGGAG
GACACCGCTCTCGCCCTTGGACAAGCACTGAAACAAGCCATTGGTGACAAACGTGGTATTGCCCGTTTCGGCTTTGTGCT
TCCAATGGACGAATGTAAAGCAGAATGTGCTTTAGATTTATCGGGCAGACCTTGGATCAAATTCAATGCCTGCTTTAAAC
GCGATAAAGTGGGCGATTTTAGTACGGAACTCACTGAACATTTCTTTCAATCTTTGGCATTTTCAATGCTTGCCACGCTT
CATTTAAATGTCACGGGTAATAACGATCATCATAAAATAGAGAGCTTATTTAAAGCCTTTGGGAGAACATTAAGACAAGC
GATTCGGATTGAAGGAAATGAAATGCCAAGTTCAAAAGGAGTTTTATAG

Upstream 100 bases:

>100_bases
TTTAAGTCACAGAGCGATTCGAGATTATTTAGTTTTATACTGTTTGTATAAAGCAAATGATAAACCTCATACCATTCATA
TAACATACACGGAGAAAAAT

Downstream 100 bases:

>100_bases
TTGAAAGAGCGGTTAATTTTTGTCGTATTTTTGCAAAATTCGACCGATTGTAAAAGGATAAAAAAATGACAAACATCACG
ATTATAGACACAGGTTGTGC

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTDAFPQTNFDKPHNVMMALFES
QGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDIDRSFVIGDRETDMQLAENLGIRAIQYDPQKMNWDLIAEKL
LGETVTNCGKRPPRFAEVIRQTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
DTALALGQALKQAIGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDFSTELTEHFFQSLAFSMLATL
HLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKGVL

Sequences:

>Translated_362_residues
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTDAFPQTNFDKPHNVMMALFES
QGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDIDRSFVIGDRETDMQLAENLGIRAIQYDPQKMNWDLIAEKL
LGETVTNCGKRPPRFAEVIRQTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
DTALALGQALKQAIGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDFSTELTEHFFQSLAFSMLATL
HLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKGVL
>Mature_362_residues
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTDAFPQTNFDKPHNVMMALFES
QGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDIDRSFVIGDRETDMQLAENLGIRAIQYDPQKMNWDLIAEKL
LGETVTNCGKRPPRFAEVIRQTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
DTALALGQALKQAIGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDFSTELTEHFFQSLAFSMLATL
HLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=362, Percent_Identity=63.2596685082873, Blast_Score=489, Evalue=1e-140,
Organism=Escherichia coli, GI1786399, Length=152, Percent_Identity=28.9473684210526, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324776, Length=171, Percent_Identity=45.6140350877193, Blast_Score=157, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 41208; Mature: 41208

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTD
CCCCEEEECCCCEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHCEEEEEEEECCCCCCCC
AFPQTNFDKPHNVMMALFESQGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDI
CCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
DRSFVIGDRETDMQLAENLGIRAIQYDPQKMNWDLIAEKLLGETVTNCGKRPPRFAEVIR
CCCEEECCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCHH
DTALALGQALKQAIGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDF
HHHHHHHHHHHHHHCCCCCHHHHCEEEEHHHHHHHEEEECCCCCCEEEHHHHCCCCCCCH
STELTEHFFQSLAFSMLATLHLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKG
HHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VL
CC
>Mature Secondary Structure
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTD
CCCCEEEECCCCEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHCEEEEEEEECCCCCCCC
AFPQTNFDKPHNVMMALFESQGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDI
CCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
DRSFVIGDRETDMQLAENLGIRAIQYDPQKMNWDLIAEKLLGETVTNCGKRPPRFAEVIR
CCCEEECCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCHH
DTALALGQALKQAIGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDF
HHHHHHHHHHHHHHCCCCCHHHHCEEEEHHHHHHHEEEECCCCCCEEEHHHHCCCCCCCH
STELTEHFFQSLAFSMLATLHLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKG
HHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA