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The map label for this gene is mltA [H]

Identifier: 148827259

GI number: 148827259

Start: 587871

End: 588980

Strand: Direct

Name: mltA [H]

Synonym: CGSHiGG_03165

Alternate gene names: 148827259

Gene position: 587871-588980 (Clockwise)

Preceding gene: 148827256

Following gene: 148827260

Centisome position: 31.15

GC content: 38.65

Gene sequence:

>1110_bases
ATGTCGATGCTTAAACCTTTCTGGTTCAAAACTTTTTCTATCTCAATTATTACCGCACTTTTGGTAGCTTGTACCTCTAA
CACAAAAAACACTCAGATTCCAACCACCTCAAATGGGAGTGATCCTCAACAATTCGGTGCTAAATATACCAATCGAACTT
ATCAGCAAACCGCTCTTGTGCCTGTTTCCTATATAGAAAACCAAAGTGCGGTAATAAATCAAGGCGATTTTTTAACACAG
CTTTCCAATATAAAAAATTATTCAAGTAAACTTTCCACCAATTTTTACGATAATTATGAAAAGATTACAAATTGGGTTCT
TTCTGGGGCAAATATTAATGAACTCACTCAATTTAATATCCAACCACAAATTATGCGTGGCTTTGATGGATTTCAAAATG
TGCTGATGACAGGCTATTATTCGCCTATACTTTATGCTCGTCATTCCCCACAAGGTCAATTTAAAAATCCAATTTATCGT
ATGCCTGTAAAAAAACGTCTAAGTCGAGCACAAATTTATGCGGGAGCATTAGCGGGAAAAAGATTAGAGTTAGCATATAG
CGATTCAATGTTAGAAAACTTTTTACTTGGTGTACAAGGCAGTGGCTATGTAGATTTTGGCGATGGCAATCTTAACTATT
TTGCTTACGCAGGACAAAATGGTTACCCTTACACGGCTATCGGGCGTTTATTAGTAGAAGATGGCGAAATTCCAAAAGAA
AAAATGTCTATTCAAGCAATTCGAGAATGGGGTAATCGTAATCCCTCTCGTGTACAAAGCTTGTTAGAACGCAATGAAGC
TTATGTATTCTTTAAAAATGATCCAAGTGGCAAAGTGAAAGGCTCTGCGGGCGTTCCTCTTGTAGCAATGGCTTCAGTGG
CATCAGATCGCAATATTATCCCATCTGGTTCTGTGCTTTTAGTCGAAGTACCCGACATTGATAATAACGGAAACTGGCTT
GGCACACACAAATTACACTTAATGGTTGCACTTGATGTAGGCGGCGCAGTGAAAGGTCATCACTTTGACTTATATCGTGG
TATCGGTGCTAGAGCGGGACATATTGCAGGGCTTTCAAAACACTACGGTAGAGTATGGGTATTACGGTAA

Upstream 100 bases:

>100_bases
ATGTGGTTTTATTAATCAACTTCGCTAAATAACACTGGTTGTTTTCAGTAAATTTTGATAGCGTATGCAGCCCTATTGTA
GCTTACTTTAGAATTAAAAA

Downstream 100 bases:

>100_bases
TGGCTAGAATAGATAATTACGAACAACGCTTTGGTGGCATTGGGCGACTTTATACGCCTGATGGCTTAGCACGCTTACGC
CAAGCGCATATTTGCGTAAT

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSMLKPFWFKTFSISIITALLVACTSNTKNTQIPTTSNGSDPQQFGAKYTNRTYQQTALVPVSYIENQSAVINQGDFLTQ
LSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNIQPQIMRGFDGFQNVLMTGYYSPILYARHSPQGQFKNPIYR
MPVKKRLSRAQIYAGALAGKRLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQNGYPYTAIGRLLVEDGEIPKE
KMSIQAIREWGNRNPSRVQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNIIPSGSVLLVEVPDIDNNGNWL
GTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSKHYGRVWVLR

Sequences:

>Translated_369_residues
MSMLKPFWFKTFSISIITALLVACTSNTKNTQIPTTSNGSDPQQFGAKYTNRTYQQTALVPVSYIENQSAVINQGDFLTQ
LSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNIQPQIMRGFDGFQNVLMTGYYSPILYARHSPQGQFKNPIYR
MPVKKRLSRAQIYAGALAGKRLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQNGYPYTAIGRLLVEDGEIPKE
KMSIQAIREWGNRNPSRVQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNIIPSGSVLLVEVPDIDNNGNWL
GTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSKHYGRVWVLR
>Mature_368_residues
SMLKPFWFKTFSISIITALLVACTSNTKNTQIPTTSNGSDPQQFGAKYTNRTYQQTALVPVSYIENQSAVINQGDFLTQL
SNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNIQPQIMRGFDGFQNVLMTGYYSPILYARHSPQGQFKNPIYRM
PVKKRLSRAQIYAGALAGKRLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQNGYPYTAIGRLLVEDGEIPKEK
MSIQAIREWGNRNPSRVQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNIIPSGSVLLVEVPDIDNNGNWLG
THKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSKHYGRVWVLR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=373, Percent_Identity=48.2573726541555, Blast_Score=341, Evalue=4e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40994; Mature: 40863

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLKPFWFKTFSISIITALLVACTSNTKNTQIPTTSNGSDPQQFGAKYTNRTYQQTALV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHEEEE
PVSYIENQSAVINQGDFLTQLSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNI
EHHHHCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHEEECC
QPQIMRGFDGFQNVLMTGYYSPILYARHSPQGQFKNPIYRMPVKKRLSRAQIYAGALAGK
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCC
RLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQNGYPYTAIGRLLVEDGEIPKE
EEEEEECHHHHHHHHEECCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCHH
KMSIQAIREWGNRNPSRVQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNII
HHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCC
PSGSVLLVEVPDIDNNGNWLGTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSK
CCCCEEEEECCCCCCCCCEEEEEEEEEEEEEECCCCCCCCEEHHHHCCCCCCCHHHHHHH
HYGRVWVLR
CCCEEEEEC
>Mature Secondary Structure 
SMLKPFWFKTFSISIITALLVACTSNTKNTQIPTTSNGSDPQQFGAKYTNRTYQQTALV
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHEEEE
PVSYIENQSAVINQGDFLTQLSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNI
EHHHHCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHEEECC
QPQIMRGFDGFQNVLMTGYYSPILYARHSPQGQFKNPIYRMPVKKRLSRAQIYAGALAGK
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCC
RLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQNGYPYTAIGRLLVEDGEIPKE
EEEEEECHHHHHHHHEECCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCHH
KMSIQAIREWGNRNPSRVQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNII
HHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCC
PSGSVLLVEVPDIDNNGNWLGTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSK
CCCCEEEEECCCCCCCCCEEEEEEEEEEEEEECCCCCCCCEEHHHHCCCCCCCHHHHHHH
HYGRVWVLR
CCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]