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The map label for this gene is gmk

Identifier: 148827160

GI number: 148827160

Start: 451767

End: 452393

Strand: Reverse

Name: gmk

Synonym: CGSHiGG_02460

Alternate gene names: 148827160

Gene position: 452393-451767 (Counterclockwise)

Preceding gene: 148827163

Following gene: 148827159

Centisome position: 23.97

GC content: 35.57

Gene sequence:

>627_bases
ATGTCTCAAGGTAATCTTTATATTTTATCTGCACCAAGTGGCGCAGGAAAATCTTCATTAATTTCTGCGTTATTGGCATC
AGATAGCTCAACTCAAAAAATGGTTTCTGTGTCACATACGACCCGTGCCCCACGCCCAGGTGAAGTTGAAGGCGTACACT
ATTATTTTGTATCAAAAGAAGAGTTTGAATCACTCATTGAGCAAGATTTATTTCTAGAATATGCCAAAGTTTTTGGTGGA
AATTATTATGGAACCTCTTTACCTGCGATTGAGGAAAATTTAGCAAAAGGCATTGATGTATTTTTAGATATTGATTGGCA
GGGCGCCCAACAAATCCGTAAAAAAGTGCCTTCAGTAAAAAGCATTTTTATTTTACCGCCTTCATTGCCTGAATTAGAGC
GTCGTTTAATTGGTCGTGGGCAAGATAGTGAAGAGGTTATTGCCGAACGAATGTCAAAAGCGATAAGTGAAATTTCGCAT
TATGACGAATATGATTATGTCATTGTGAATGATGATTTTGAGAAAACATTAAAAGATTTACAAAGTATTTTGCAATCGGA
ACGCTTAACTAAAGATTATCAACAAAAACAAAATGCAATGTTAATTCAACAGCTACTAGCAAAATAG

Upstream 100 bases:

>100_bases
AGAATGAAAAAGTACCGTAAAAAATCACCGCACTTTTGATGATTTTTTATAGAGAAATCTGCATAATAGACTGAAGTTGT
TAGAGAAGGTTAAATATTCT

Downstream 100 bases:

>100_bases
GGCGAAATTGAGTATTATAACGCCCTTTCAATAGAGTAATTTTGACAAATCGGAGTAAATTATGGCTCGTGTTACTGTGC
AAGATGCGGTAGAAAAAATT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKEEFESLIEQDLFLEYAKVFGG
NYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVKSIFILPPSLPELERRLIGRGQDSEEVIAERMSKAISEISH
YDEYDYVIVNDDFEKTLKDLQSILQSERLTKDYQQKQNAMLIQQLLAK

Sequences:

>Translated_208_residues
MSQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKEEFESLIEQDLFLEYAKVFGG
NYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVKSIFILPPSLPELERRLIGRGQDSEEVIAERMSKAISEISH
YDEYDYVIVNDDFEKTLKDLQSILQSERLTKDYQQKQNAMLIQQLLAK
>Mature_207_residues
SQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKEEFESLIEQDLFLEYAKVFGGN
YYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVKSIFILPPSLPELERRLIGRGQDSEEVIAERMSKAISEISHY
DEYDYVIVNDDFEKTLKDLQSILQSERLTKDYQQKQNAMLIQQLLAK

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=192, Percent_Identity=40.1041666666667, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI226874833, Length=192, Percent_Identity=40.1041666666667, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI4504221, Length=192, Percent_Identity=40.1041666666667, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI111154074, Length=180, Percent_Identity=32.2222222222222, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI14780902, Length=195, Percent_Identity=30.2564102564103, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI38570142, Length=177, Percent_Identity=31.638418079096, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI52630447, Length=193, Percent_Identity=28.4974093264249, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI21536464, Length=167, Percent_Identity=31.1377245508982, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21361598, Length=203, Percent_Identity=27.0935960591133, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1790080, Length=207, Percent_Identity=64.7342995169082, Blast_Score=280, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI193203132, Length=184, Percent_Identity=38.0434782608696, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=184, Percent_Identity=38.0434782608696, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17557440, Length=183, Percent_Identity=32.2404371584699, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=140, Percent_Identity=33.5714285714286, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988041, Length=179, Percent_Identity=25.6983240223464, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=150, Percent_Identity=28, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=41.6216216216216, Blast_Score=142, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21356141, Length=173, Percent_Identity=43.3526011560694, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI116007136, Length=181, Percent_Identity=29.8342541436464, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640542, Length=181, Percent_Identity=29.8342541436464, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45554489, Length=181, Percent_Identity=29.8342541436464, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI161077626, Length=175, Percent_Identity=30.2857142857143, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI85724806, Length=181, Percent_Identity=29.8342541436464, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45554481, Length=181, Percent_Identity=29.8342541436464, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_HAEI8 (Q4QJK3)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_249454.1
- HSSP:   P60546
- ProteinModelPortal:   Q4QJK3
- SMR:   Q4QJK3
- STRING:   Q4QJK3
- GeneID:   3431303
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI2054
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q4QJK3
- ProtClustDB:   PRK00300
- BioCyc:   HINF281310:NTHI2054-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23401; Mature: 23270

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKE
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECHH
EFESLIEQDLFLEYAKVFGGNYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCC
SIFILPPSLPELERRLIGRGQDSEEVIAERMSKAISEISHYDEYDYVIVNDDFEKTLKDL
EEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
QSILQSERLTKDYQQKQNAMLIQQLLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKE
CCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECHH
EFESLIEQDLFLEYAKVFGGNYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCC
SIFILPPSLPELERRLIGRGQDSEEVIAERMSKAISEISHYDEYDYVIVNDDFEKTLKDL
EEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
QSILQSERLTKDYQQKQNAMLIQQLLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA