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The map label for this gene is map

Identifier: 148827140

GI number: 148827140

Start: 420964

End: 421770

Strand: Reverse

Name: map

Synonym: CGSHiGG_02345

Alternate gene names: 148827140

Gene position: 421770-420964 (Counterclockwise)

Preceding gene: 148827145

Following gene: 148827139

Centisome position: 22.35

GC content: 40.02

Gene sequence:

>807_bases
ATGGCTATTCCAATTAGAACTGAAAAAGAAATTGTAAAGTTACGTGAGGCCTGCAAATTGGCTTCCGATGTGCTGGTAAT
GATTGAACCTTACGTAAAAGCAGGCGTAACCACAGGCGAACTTGATCGCATTTGCCATGAATATATGGTAAATGAACAAA
AGGTTATCCCTGCGTGTTTGAATTATCACGGTTTCCCAAAGGCGACCTGTATTTCCATTAACGAAGTCGTTTGTCACGGT
ATTCCAAGTGACGATAAAGTGTTAAAAAATGGCGATATTGTGAATATTGATGTTACCGTGATTAAAGACGGTTATTTTGG
CGATAACTCAAAAATGTATATCGTGGGCGGAGAAACAAATATTCGTAGTAAAAAATTAGTGGAAGCGGCACAAGAAGCAT
TATATGTTGGGATACGCACTGTAAAACCCGATATTCGTTTAAATGAAATAGGTAAAGCTGTGCAAAAATATACTGAAAGC
CAGACTTTCAGCGTTGTGCGTGAATATTGCGGACATGGTGTCGGTACGGAATTTCACTGCGAACCTCAAGTATTGCATTA
TTATGCCGATGATGGCGGCGTGATTTTAAAACCCGGAATGGTGTTTACCATTGAGCCAATGATTAACGCAGGCAAAAAAG
AAGTGCGCGTAATGGGAGATGGTTGGACAGTAAAAACCAAAGATCGCAGCCATTCAGCACAATATGAACATCAACTTATT
GTCACGGAAACTGGTTGTGAAGTAATGACTATCCGCGATGAAGAAATTGCAGAAGGTCGAATTTCACGGATTATGGTGAA
TGTGTAA

Upstream 100 bases:

>100_bases
CATTATCTAATAACCCTTTACTCCATTCAAGTGCAATCCAGTTTTTTCCTAGAAATCGTGCTATAATCTCGCAAAGTTTT
TTCAAAAAAGTGAGATAAAA

Downstream 100 bases:

>100_bases
TTGACATTAAATTATAGGATAAGGGCGTAGATATACGCCCTTTTTGTTTTTCTTTATAATAAAACGACTTCGATCTAACA
AAAGGCAATTCATATGCTGT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MAIPIRTEKEIVKLREACKLASDVLVMIEPYVKAGVTTGELDRICHEYMVNEQKVIPACLNYHGFPKATCISINEVVCHG
IPSDDKVLKNGDIVNIDVTVIKDGYFGDNSKMYIVGGETNIRSKKLVEAAQEALYVGIRTVKPDIRLNEIGKAVQKYTES
QTFSVVREYCGHGVGTEFHCEPQVLHYYADDGGVILKPGMVFTIEPMINAGKKEVRVMGDGWTVKTKDRSHSAQYEHQLI
VTETGCEVMTIRDEEIAEGRISRIMVNV

Sequences:

>Translated_268_residues
MAIPIRTEKEIVKLREACKLASDVLVMIEPYVKAGVTTGELDRICHEYMVNEQKVIPACLNYHGFPKATCISINEVVCHG
IPSDDKVLKNGDIVNIDVTVIKDGYFGDNSKMYIVGGETNIRSKKLVEAAQEALYVGIRTVKPDIRLNEIGKAVQKYTES
QTFSVVREYCGHGVGTEFHCEPQVLHYYADDGGVILKPGMVFTIEPMINAGKKEVRVMGDGWTVKTKDRSHSAQYEHQLI
VTETGCEVMTIRDEEIAEGRISRIMVNV
>Mature_267_residues
AIPIRTEKEIVKLREACKLASDVLVMIEPYVKAGVTTGELDRICHEYMVNEQKVIPACLNYHGFPKATCISINEVVCHGI
PSDDKVLKNGDIVNIDVTVIKDGYFGDNSKMYIVGGETNIRSKKLVEAAQEALYVGIRTVKPDIRLNEIGKAVQKYTESQ
TFSVVREYCGHGVGTEFHCEPQVLHYYADDGGVILKPGMVFTIEPMINAGKKEVRVMGDGWTVKTKDRSHSAQYEHQLIV
TETGCEVMTIRDEEIAEGRISRIMVNV

Specific function: Removes the amino-terminal methionine from nascent proteins

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=44, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=38.5542168674699, Blast_Score=191, Evalue=6e-49,
Organism=Escherichia coli, GI1786364, Length=262, Percent_Identity=64.5038167938931, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1788728, Length=219, Percent_Identity=26.027397260274, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=44.2231075697211, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6323273, Length=262, Percent_Identity=43.5114503816794, Blast_Score=228, Evalue=9e-61,
Organism=Drosophila melanogaster, GI21355531, Length=252, Percent_Identity=43.6507936507937, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24583427, Length=250, Percent_Identity=41.6, Blast_Score=205, Evalue=3e-53,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): AMPM_HAEIN (P44421)

Other databases:

- EMBL:   L42023
- PIR:   C64138
- RefSeq:   NP_439863.1
- ProteinModelPortal:   P44421
- SMR:   P44421
- MEROPS:   M24.001
- GeneID:   950876
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1722
- NMPDR:   fig|71421.1.peg.1634
- TIGR:   HI_1722
- HOGENOM:   HBG299384
- OMA:   MTIREEE
- ProtClustDB:   PRK05716
- BioCyc:   HINF71421:HI_1722-MONOMER
- BRENDA:   3.4.11.18
- GO:   GO:0006508
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804:SF13
- PANTHER:   PTHR10804
- PRINTS:   PR00599
- TIGRFAMs:   TIGR00500

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.11.18

Molecular weight: Translated: 29897; Mature: 29766

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00680 MAP_1

Important sites: BINDING 79-79 BINDING 99-99 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPIRTEKEIVKLREACKLASDVLVMIEPYVKAGVTTGELDRICHEYMVNEQKVIPACL
CCCCCCCHHHHHHHHHHHHHHHCEEEEEEHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHH
NYHGFPKATCISINEVVCHGIPSDDKVLKNGDIVNIDVTVIKDGYFGDNSKMYIVGGETN
CCCCCCCEEEEEEHHHEECCCCCCCCEECCCCEEEEEEEEEECCEECCCCEEEEECCCCC
IRSKKLVEAAQEALYVGIRTVKPDIRLNEIGKAVQKYTESQTFSVVREYCGHGVGTEFHC
CCHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEC
EPQVLHYYADDGGVILKPGMVFTIEPMINAGKKEVRVMGDGWTVKTKDRSHSAQYEHQLI
CCEEEEEEECCCCEEECCCEEEEEEHHHCCCCEEEEEEECCEEEEECCCCCCCCCCEEEE
VTETGCEVMTIRDEEIAEGRISRIMVNV
EEECCCEEEEECCHHHHCCCEEEEEEEC
>Mature Secondary Structure 
AIPIRTEKEIVKLREACKLASDVLVMIEPYVKAGVTTGELDRICHEYMVNEQKVIPACL
CCCCCCHHHHHHHHHHHHHHHCEEEEEEHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHH
NYHGFPKATCISINEVVCHGIPSDDKVLKNGDIVNIDVTVIKDGYFGDNSKMYIVGGETN
CCCCCCCEEEEEEHHHEECCCCCCCCEECCCCEEEEEEEEEECCEECCCCEEEEECCCCC
IRSKKLVEAAQEALYVGIRTVKPDIRLNEIGKAVQKYTESQTFSVVREYCGHGVGTEFHC
CCHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEC
EPQVLHYYADDGGVILKPGMVFTIEPMINAGKKEVRVMGDGWTVKTKDRSHSAQYEHQLI
CCEEEEEEECCCCEEECCCEEEEEEHHHCCCCEEEEEEECCEEEEECCCCCCCCCCEEEE
VTETGCEVMTIRDEEIAEGRISRIMVNV
EEECCCEEEEECCHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800