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The map label for this gene is wecA [H]

Identifier: 148827139

GI number: 148827139

Start: 417135

End: 418202

Strand: Reverse

Name: wecA [H]

Synonym: CGSHiGG_02330

Alternate gene names: 148827139

Gene position: 418202-417135 (Counterclockwise)

Preceding gene: 148827140

Following gene: 148827137

Centisome position: 22.16

GC content: 36.89

Gene sequence:

>1068_bases
ATGCTGAGTATTTTTGTTACTTTTCTTGGCGCGTTTTTAACATTGATTGTGATGCGACCACTTGCCAATTGGATTGGATT
AGTTGATAAGCCAAATTATCGTAAACGTCATCAAGGCACAATTCCACTAATCGGTGGCGTATCGCTTTTTGTTGGAAATC
TTTGCTATTATTTGATGGAATGGGATCAGCTTCGATTACCGTATCTTTATTTGTTCAGTATTTTTGTTTTATTGGCGATT
GGGATTTTAGATGATCGCTTTGATATTAGCCCTTTTTTAAGAGCAGGCATTCAAGCAATATTGGCGATTTTAATGATCGA
TCTTGGGAATATTTATCTTGATCATCTTGGTCAAATTTTAGGGCCTTTCCAATTAACGCTCGGTTCAATTGGTTTGATTA
TTACCGTTTTTGCTACTATTGCGATTATTAATGCCTTTAATATGATTGATGGTATTGATGGATTGCTTGGGGGACTCTCT
TGTGTTTCTTTTGCGGCGATTGGTATTTTAATGTATCGAGATGGGCAAATGGATATGGCACATTGGAGTTTTGCTTTAAT
CGTATCGATTTTACCTTATTTGATGCTCAATCTAGGGATTCCATTTGGACCAAAATATAAGGTGTTTATGGGGGATGCCG
GGAGTACATTAATTGGCTTTACCATTATTTGGATTTTGTTATTAAGTACGCAAGGAAAAGGGCATCCTATGAATCCAGTA
ACCGCACTTTGGATTATTGCGATTCCTTTGATTGATATGGTTGCGATTATTTATCGCCGTGTACGTAAAGGTAAAAGCCC
ATTCCGTCCAGATCGTTTACATGTTCATCATTTAATGGTAAGAGCGGGTTTAACATCAAGACAAGCCTTTTTATTGATTA
CGTTTGTTTCTGCAGTTTGTGCAACTATTGGTATTTTAGGGGAAGTTTATTATGTGAATGAGTGGGCGATGTTTGTTGGT
TTTTTCATTTTATTTTTCCTTTATGTCTATTCAATTACGCATGCATGGCGAATTACCCGTTGGGTAAGAAGAATGAAACG
TCGTGCCAAACGGTTGAAGAAAGCATAA

Upstream 100 bases:

>100_bases
ACGTGCTATATCGAAATATTGGATAGTCCTTTTTATAAAAATATATTTCTAGGTAAATTTGCCTTATGTTATCCTTTATA
AAAAATTTTAGGGTCACACT

Downstream 100 bases:

>100_bases
AAAAATAAAGGCTTGTGTTATTAAATCACAAGCCTTTATTTTTTGAGAAAATTCACCGCACTTTTTAACATTTTGATGAT
CTATTTTTATAGATAGAAAA

Product: oligoribonuclease

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGVSLFVGNLCYYLMEWDQLRLPYLYLFSIFVLLAI
GILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQILGPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLS
CVSFAAIGILMYRDGQMDMAHWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVCATIGILGEVYYVNEWAMFVG
FFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA

Sequences:

>Translated_355_residues
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGVSLFVGNLCYYLMEWDQLRLPYLYLFSIFVLLAI
GILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQILGPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLS
CVSFAAIGILMYRDGQMDMAHWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVCATIGILGEVYYVNEWAMFVG
FFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA
>Mature_355_residues
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGVSLFVGNLCYYLMEWDQLRLPYLYLFSIFVLLAI
GILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQILGPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLS
CVSFAAIGILMYRDGQMDMAHWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVCATIGILGEVYYVNEWAMFVG
FFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) [H]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=328, Percent_Identity=60.3658536585366, Blast_Score=369, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 40099; Mature: 40099

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGVSLFVGNLCYYLME
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHH
WDQLRLPYLYLFSIFVLLAIGILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQIL
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLSCVSFAAIGILMYRDGQMDMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
HWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ATIGILGEVYYVNEWAMFVGFFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGVSLFVGNLCYYLME
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHH
WDQLRLPYLYLFSIFVLLAIGILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQIL
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLSCVSFAAIGILMYRDGQMDMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
HWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ATIGILGEVYYVNEWAMFVGFFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]