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The map label for this gene is truC [H]

Identifier: 148826937

GI number: 148826937

Start: 181502

End: 182221

Strand: Reverse

Name: truC [H]

Synonym: CGSHiGG_01055

Alternate gene names: 148826937

Gene position: 182221-181502 (Counterclockwise)

Preceding gene: 148826938

Following gene: 148826936

Centisome position: 9.66

GC content: 35.97

Gene sequence:

>720_bases
ATGCTAGAAATTTTATATCAAGATGAGTTTCTCGTTGCGGTGAATAAGCCTGCTGGTATGCTGGTTCATCGCAGTTGGTT
AGATCCTCACGAAACTCAATTTGTGATGCAAACTTTACGAGATCAGATTGGTCAGCACGTATTTCCTATTCATCGTTTAG
ATCGACCGACATCTGGCGTGTTGTTATTTGCATTGAGCAGTGAAATTGCGAATTTAATGTGTGAACAGTTTGAACAAAAG
TACGTTCAGAAATCTTATTTGGCTGTAGTGCGAGGGTATCTACAGGGAAAAGAGCGGATAGATTATCCACTAAAAATTCA
ATTGGATAAAATCGCAGATAAATTTTCTCAAGAAGATAAAGAGCCTCAAGAAGCCGTTACTGATTATGAAGGATTAAAAA
TAGTAGAAATGCCTTATCCTGCAGGGCGTTATCAAACGGCACGTTATTCTTTAGTTAAATTAATCCCTCATACAGGTAGA
AAACACCAATTACGTCGCCATATGAAACATATTTTTCACCCAATTTTAGGGGATACGCAATATGGTGACTTACATCAAAA
TCGTGCATTAATGTCACATTTAGGTTGTTCTCGATTATTTTTACATTCTAATAGTTTGTCTTTTATTCATCCAATAACGA
AAGAGCAAATAACAATTACAGCAGGTTTAGATGAACAATGGCAGCAATTAATGAATCAATTTGGATGGGAAAATGTTTGA

Upstream 100 bases:

>100_bases
CTATTTCTCCTTATATTGAAGAAGCAATGAAGGAATTTGATGAGTTACAACAACTATTAACTCCTTTAGTTGCTTTAGAA
GAACTTCTGAACAATAACCA

Downstream 100 bases:

>100_bases
TATTAACTTAACACACGAACAGCAACAAAAAGCAGTTGAGCAAATTCAAGAACTTATGGCAAAAGGAATTAGTAGTGGAG
AAGCGATTCAAATAGTGGCG

Product: tRNA pseudouridine synthase C

Products: NA

Alternate protein names: tRNA pseudouridylate synthase C; tRNA-uridine isomerase C [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MLEILYQDEFLVAVNKPAGMLVHRSWLDPHETQFVMQTLRDQIGQHVFPIHRLDRPTSGVLLFALSSEIANLMCEQFEQK
YVQKSYLAVVRGYLQGKERIDYPLKIQLDKIADKFSQEDKEPQEAVTDYEGLKIVEMPYPAGRYQTARYSLVKLIPHTGR
KHQLRRHMKHIFHPILGDTQYGDLHQNRALMSHLGCSRLFLHSNSLSFIHPITKEQITITAGLDEQWQQLMNQFGWENV

Sequences:

>Translated_239_residues
MLEILYQDEFLVAVNKPAGMLVHRSWLDPHETQFVMQTLRDQIGQHVFPIHRLDRPTSGVLLFALSSEIANLMCEQFEQK
YVQKSYLAVVRGYLQGKERIDYPLKIQLDKIADKFSQEDKEPQEAVTDYEGLKIVEMPYPAGRYQTARYSLVKLIPHTGR
KHQLRRHMKHIFHPILGDTQYGDLHQNRALMSHLGCSRLFLHSNSLSFIHPITKEQITITAGLDEQWQQLMNQFGWENV
>Mature_239_residues
MLEILYQDEFLVAVNKPAGMLVHRSWLDPHETQFVMQTLRDQIGQHVFPIHRLDRPTSGVLLFALSSEIANLMCEQFEQK
YVQKSYLAVVRGYLQGKERIDYPLKIQLDKIADKFSQEDKEPQEAVTDYEGLKIVEMPYPAGRYQTARYSLVKLIPHTGR
KHQLRRHMKHIFHPILGDTQYGDLHQNRALMSHLGCSRLFLHSNSLSFIHPITKEQITITAGLDEQWQQLMNQFGWENV

Specific function: Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs [H]

COG id: COG0564

COG function: function code J; Pseudouridylate synthases, 23S RNA-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudouridine synthase rluA family [H]

Homologues:

Organism=Homo sapiens, GI23308689, Length=184, Percent_Identity=28.804347826087, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI17158025, Length=201, Percent_Identity=29.3532338308458, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI221316667, Length=186, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789155, Length=239, Percent_Identity=63.1799163179916, Blast_Score=316, Evalue=9e-88,
Organism=Escherichia coli, GI1787327, Length=233, Percent_Identity=34.3347639484979, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786244, Length=224, Percent_Identity=34.375, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788946, Length=248, Percent_Identity=26.6129032258064, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324506, Length=185, Percent_Identity=28.6486486486486, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320168, Length=184, Percent_Identity=28.804347826087, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321608, Length=225, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583449, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583447, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583445, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921090, Length=187, Percent_Identity=30.4812834224599, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR006224
- InterPro:   IPR006145 [H]

Pfam domain/function: PF00849 PseudoU_synth_2 [H]

EC number: NA

Molecular weight: Translated: 27912; Mature: 27912

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS01129 PSI_RLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEILYQDEFLVAVNKPAGMLVHRSWLDPHETQFVMQTLRDQIGQHVFPIHRLDRPTSGV
CCEEEEECCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCE
LLFALSSEIANLMCEQFEQKYVQKSYLAVVRGYLQGKERIDYPLKIQLDKIADKFSQEDK
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEHHHHHHHHHHCCC
EPQEAVTDYEGLKIVEMPYPAGRYQTARYSLVKLIPHTGRKHQLRRHMKHIFHPILGDTQ
CHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
YGDLHQNRALMSHLGCSRLFLHSNSLSFIHPITKEQITITAGLDEQWQQLMNQFGWENV
CCHHHHHHHHHHHCCHHHEEEECCCCCEECCCCCCEEEEEECCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLEILYQDEFLVAVNKPAGMLVHRSWLDPHETQFVMQTLRDQIGQHVFPIHRLDRPTSGV
CCEEEEECCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCE
LLFALSSEIANLMCEQFEQKYVQKSYLAVVRGYLQGKERIDYPLKIQLDKIADKFSQEDK
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEHHHHHHHHHHCCC
EPQEAVTDYEGLKIVEMPYPAGRYQTARYSLVKLIPHTGRKHQLRRHMKHIFHPILGDTQ
CHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
YGDLHQNRALMSHLGCSRLFLHSNSLSFIHPITKEQITITAGLDEQWQQLMNQFGWENV
CCHHHHHHHHHHHCCHHHEEEECCCCCEECCCCCCEEEEEECCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]