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The map label for this gene is sbcB [H]

Identifier: 148826869

GI number: 148826869

Start: 131528

End: 133084

Strand: Direct

Name: sbcB [H]

Synonym: CGSHiGG_00695

Alternate gene names: 148826869

Gene position: 131528-133084 (Clockwise)

Preceding gene: 148826868

Following gene: 148826870

Centisome position: 6.97

GC content: 38.54

Gene sequence:

>1557_bases
ATGAACATTCAAACTCAAGCCTTTATTGCGGTGACAGCTCAACCCATTCCCTATTATGCTGACACCACCGCTATTTTTAA
TACGCTTTGCCAACCTAATTCAAATTCTCTTCTACTCGACTCTGCCGAAATCGGGAGTAAAAATAGTTTACAAAGCCTTA
TCTTAGTCAATGCTGCAGTTAAAATAACGTGCTTAGGTCACAACGTCACATTTAAAGCATTAAATGAGAACGGAAAACAA
GTTTTAAAAGAAATTCATCCAAAATTAACCGCACTTGGAAAAGTAAGTGCTGTCAATTTTGAAGAAGAATTTTCTGTACA
ATTTTCGCCACTTGATAATCAACTTGATGAAGATAGTAAATTACAGTCTGCTACTATTTTTGATGGTCTGCGTGTTATTT
CTAGTCTTTATCAACATAGCCAAACGCCTATTTTCTTAGGCGGATTATTTGCTTACGATCTCGTCGCAAATTTTATTCCA
ATGGATGGTATTACATTGCAAAATGATGGTATCAACTGCCCTGATTACAGTTTCTATCTTGCCGAACATCTCATTACCAT
CGATCATCAAAATCAACAAGCAACACTCAAAAGTTTCTGTTTTGCTCAAGAAGAACAAGTTAATATTGCGAAAACCTCAC
TTTCTATCGCACAAAAACTAAAAAATATTGATAACGTTCTTTCTATCAAAGCGGCAAGTGATGAGGTTAAAACAAACTTT
GACGATCCTGAATTTACCAGCATTGTAAAAGCATTAAAACACCATATTAACATTGGTGATGTCTTCCAAATTGTGCCTTC
TCGCCGTTTCTCCCTTGCTTGCCCGAATACATTAGCCAGTTACGCTCAACTCAAACAAAATAATCCAAGCCCTTATATGT
TCTATATGAATGATGAAGACTTTATTTTGTTTGGTGCATCGCCAGAAAGTGCGCTGAAATATGCGCCAGAAAATCGTCAG
TTAGAAATTTACCCAATCGCAGGTTCACGCCCTCGTGGTTTTAATGCTCACGGCAACATTGATCCTGAATTGGATGCGCG
TTTAGAACTAGAACTTCGCCTTGATCATAAAGAACAAGCAGAACATTTAATGTTAGTTGATTTAGCGCGTAACGACATTG
CTCGAGTTTGCCAAAGTGGTACCCGTAAAGTGGCAGAATTAATGCAAGTGGATCGCTATTCTCACATTATGCATTTAGTG
TCTCGTGTGGTAGGTAAATTACGCCCTGAATTAGATGCACTTCACGCCTATCAAGCCTGTATGAATATGGGCACATTAAC
TGGAGCCCCCAAAATTAAAGCAATGCAGCTTATTTATCAATTTGAGCAACAAAAACGCCATAGTTACGGTGGTGCGGTGG
GTTATCTCACGTCTGATGGACATTTTGATACCTGTATCGTGATTCGTTCTGCTTTCGTACAAAATGGGATAGCCCATGTA
CAAGCAGGTTGCGGTGAAGTATTGGATTCTGATCCACAAATGGAAGCTGATGAAACACGCCATAAAGCAGTGGCTGTCTT
AAAAGCAATTCGTCAAGTTAATACACAAGCAAAATAA

Upstream 100 bases:

>100_bases
ACAATTTTTAATCAAAAAGTATAAAAAATAAAAATCAGGCTTGACTTATTTCTTTTGCACTAGTTTAATAGTACAAAATT
TTCCAAAAGGATAAATAAAT

Downstream 100 bases:

>100_bases
GGAAGAATTATTATGGCTAATATTTTATTTTTAGATAACTTCGATTCCTTCACTTACAATCTTGTGGATCAATTTCGTGT
ATTAGGTCACAACGTCACAA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MNIQTQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNAAVKITCLGHNVTFKALNENGKQ
VLKEIHPKLTALGKVSAVNFEEEFSVQFSPLDNQLDEDSKLQSATIFDGLRVISSLYQHSQTPIFLGGLFAYDLVANFIP
MDGITLQNDGINCPDYSFYLAEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
DDPEFTSIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDEDFILFGASPESALKYAPENRQ
LEIYPIAGSRPRGFNAHGNIDPELDARLELELRLDHKEQAEHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLV
SRVVGKLRPELDALHAYQACMNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
QAGCGEVLDSDPQMEADETRHKAVAVLKAIRQVNTQAK

Sequences:

>Translated_518_residues
MNIQTQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNAAVKITCLGHNVTFKALNENGKQ
VLKEIHPKLTALGKVSAVNFEEEFSVQFSPLDNQLDEDSKLQSATIFDGLRVISSLYQHSQTPIFLGGLFAYDLVANFIP
MDGITLQNDGINCPDYSFYLAEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
DDPEFTSIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDEDFILFGASPESALKYAPENRQ
LEIYPIAGSRPRGFNAHGNIDPELDARLELELRLDHKEQAEHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLV
SRVVGKLRPELDALHAYQACMNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
QAGCGEVLDSDPQMEADETRHKAVAVLKAIRQVNTQAK
>Mature_518_residues
MNIQTQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNAAVKITCLGHNVTFKALNENGKQ
VLKEIHPKLTALGKVSAVNFEEEFSVQFSPLDNQLDEDSKLQSATIFDGLRVISSLYQHSQTPIFLGGLFAYDLVANFIP
MDGITLQNDGINCPDYSFYLAEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
DDPEFTSIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDEDFILFGASPESALKYAPENRQ
LEIYPIAGSRPRGFNAHGNIDPELDARLELELRLDHKEQAEHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLV
SRVVGKLRPELDALHAYQACMNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
QAGCGEVLDSDPQMEADETRHKAVAVLKAIRQVNTQAK

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=502, Percent_Identity=52.390438247012, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1788114, Length=406, Percent_Identity=29.5566502463054, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI87082077, Length=271, Percent_Identity=27.6752767527675, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786809, Length=228, Percent_Identity=30.2631578947368, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=379, Percent_Identity=36.6754617414248, Blast_Score=210, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6324361, Length=391, Percent_Identity=24.2966751918159, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57551; Mature: 57551

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQTQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNAAV
CCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHEEEEEE
KITCLGHNVTFKALNENGKQVLKEIHPKLTALGKVSAVNFEEEFSVQFSPLDNQLDEDSK
EEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEECCHHHCCEEECCCCCCCCCCHH
LQSATIFDGLRVISSLYQHSQTPIFLGGLFAYDLVANFIPMDGITLQNDGINCPDYSFYL
HHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHH
AEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
HHHHEEEECCCHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHCCC
DDPEFTSIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDED
CCHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCC
FILFGASPESALKYAPENRQLEIYPIAGSRPRGFNAHGNIDPELDARLELELRLDHKEQA
EEEECCCCHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHH
EHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLVSRVVGKLRPELDALHAYQAC
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHH
QAGCGEVLDSDPQMEADETRHKAVAVLKAIRQVNTQAK
HHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIQTQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNAAV
CCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHEEEEEE
KITCLGHNVTFKALNENGKQVLKEIHPKLTALGKVSAVNFEEEFSVQFSPLDNQLDEDSK
EEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEECCHHHCCEEECCCCCCCCCCHH
LQSATIFDGLRVISSLYQHSQTPIFLGGLFAYDLVANFIPMDGITLQNDGINCPDYSFYL
HHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHH
AEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
HHHHEEEECCCHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHCCC
DDPEFTSIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDED
CCHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCC
FILFGASPESALKYAPENRQLEIYPIAGSRPRGFNAHGNIDPELDARLELELRLDHKEQA
EEEECCCCHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHH
EHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLVSRVVGKLRPELDALHAYQAC
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHH
QAGCGEVLDSDPQMEADETRHKAVAVLKAIRQVNTQAK
HHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]