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The map label for this gene is parC [H]

Identifier: 148826812

GI number: 148826812

Start: 50833

End: 53076

Strand: Reverse

Name: parC [H]

Synonym: CGSHiGG_00310

Alternate gene names: 148826812

Gene position: 53076-50833 (Counterclockwise)

Preceding gene: 148826813

Following gene: 148826811

Centisome position: 2.81

GC content: 40.46

Gene sequence:

>2244_bases
ATGACAAATATCAACTATGAAGGCATTGAGCAAATGCCTCTACGCACCTTCACTGAAAAGGCTTATCTCAACTATTCTAT
GTATGTCATCATGGATCGTGCGTTGCCTTTTATCGGTGATGGTTTAAAACCCGTTCAACGTCGTATTGTATATGCGATGT
CTGAACTTGGCTTAAATGCCACGGCAAAATACAAAAAATCTGCTCGTACCGTCGGTGATGTACTTGGTAAATTCCATCCA
CATGGTGACAGCGCTTGTTATGAAGCTATGGTGTTAATGGCACAACCCTTCTCTTATCGTTATCCGCTTGTAGATGGTCA
AGGTAACTGGGGGGCGCCAGATGATCCAAAATCCTTCGCAGCCATGCGTTATACGGAATCTCGCCTATCTAAAATCGCTG
AAATCTTGTTGAGTGAACTCGGACAAGGAACAGTAGATTATCAACCAAACTTTGATGGAACCTTAGCTGAACCACAATAT
TTACCTGCTCGTTTACCTCATATTTTATTGAACGGCACAACAGGTATTGCGGTGGGGATGGCCACAGATATTCCACCACA
CAATATTAACGAAATTGCTGATGCGGCAGTAATGTTGCTAGATAATCCTAAAGCGAGATTAGATGATGTACTTGAAATTG
TTCAAGGCCCAGATTTTCCAACAGAAGCGGAAATTATTTCGCCAAAATCAGAAATTCGTAAAATTTATGAGCAAGGCCGT
GGCTCAATAAAAATGCGTGCAACTTGGAAAAAAGAAGACGGCGAGATCATTATTTCTGCACTTCCACATCAATCTTCTCC
CTCAAAAGTTATTGCACAAATAGCCGATCAAATGACAGCCAAAAAACTGCCAATGCTAGAAGATATTCGAGATGAAGCCG
ATCACGAAAACCCAATTCGCATTGTGCTAGTCCCTCGCTCAAATCGCGTCGATACTGATGCCTTAATGGCACATTTATTC
GCGACCACAGATCTTGAAAAAAGCTACCGTGTAAATATGAATATGATCGGGCTTGATCATAAACCTGCGGTAAAAGGCTT
ATTAGAAATCTTAAATGAATGGCTCACTTTCCGTCGCACAACGGTCACTCGTCGCCTTCAATATCGCTTAGATAAAGTAC
TCTCTCGCTTGCATATTTTAGAAGGCTTGATGATAGCCTTTTTAAATATTGATGAAGTTATCGAAATTATACGCCACGAA
GATGATCCAAAAGCAGAGCTTATGGCACGCTTTAATTTAAGCGATGAACAAGCCGATGCCATTTTAAATTTACGCTTACG
TCATTTAGCGAAATTAGAAGAAAACCAACTCAAAGCAGAACAAGATGAACTTGAAAAAGAGCGGTTAAATTTAGAAGCAA
TTTTAGGATCAGAACGCCGTTTGAATACGCTTATCAAAAAAGAAATTCAAGAAGATGCGAAAAAATATGCCAGTCCACGT
ATGTCTCAACTGGTCGAACGTGAAGAAGCCAAAATGATCTCTGAAAGTGATATGACGCCAGCAGAACCAGTTACTGTCAT
CTTATCAGAAATGGGCTGGGTACGTTGTGCAAAAGGACACGATATTGATCCTAAATCATTAAGCTACAAAGCTGGCGATA
GCTATCTAGCTCACGCTTGTGGCAAAAGTAATCAAGCCGTTGTATTCATTGATAGCACGGGGCGGAGTTATGCACTCGAT
CCGCTTTCATTGCCTTCCGCTCGTTCCCAAGGCGAACCACTTACAGGTAAACTCAATTTACCCACTGGTGCGACCATTGA
ATATGTTGTAATGGCCAGCGAACAGCAAGAATTATTGATGGCTTCTGATGCGGGATATGGTTTTATTTGTAAATTTGAAG
ATTTAATTGCACGTAACAAGACTGGAAAAGCCTTGATTTCTTTACCAGAAAATGCCAAAGTGTTGAAGCCTAAAACATTG
ATAAATTCTACCGCACTTGTTGTCGCAATCACATCAGCAGGCAGAATGTTGATTTTTCCAGCACAGGATTTACCGGTATT
ATCAAAAGGTAAAGGCAATAAAATGATCACTATTCCCGCAGCGAATGCAAAAGATCGTAGCGAACTATTGACAAAATTAT
TGCTTATTTCAGATCAAGCAAGTCTTGAATTTTATTCTGGAAAACGAAAAATTGTATTAAAACCAGAAGATCTGCAAAAG
TTCCGCGCAGAACGAGGCAGAAAAGGTTCGACATTACCACGTGGATTACATACCAATCTTGAAATTATGGTAGTCGAGCC
ATAA

Upstream 100 bases:

>100_bases
AGCGAAAGGCGATCAGGTTGATTTATCTGTTTAGACTAAATTAATCTCAGCAAATCTGAATTTTAATAAATTAAGAATAT
ATCAATTAACAGAAACAAAA

Downstream 100 bases:

>100_bases
CACAACACATCACTTAAACATAACTTAGGGAGATCCAATTTATGAGCTATACTTTTAGCACGTATGAAACCCTTGCATTA
GCAAGCTTAGTTTTGCTATT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MTNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKYKKSARTVGDVLGKFHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKIAEILLSELGQGTVDYQPNFDGTLAEPQY
LPARLPHILLNGTTGIAVGMATDIPPHNINEIADAAVMLLDNPKARLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGR
GSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIADQMTAKKLPMLEDIRDEADHENPIRIVLVPRSNRVDTDALMAHLF
ATTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLTFRRTTVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHE
DDPKAELMARFNLSDEQADAILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYASPR
MSQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHACGKSNQAVVFIDSTGRSYALD
PLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLMASDAGYGFICKFEDLIARNKTGKALISLPENAKVLKPKTL
INSTALVVAITSAGRMLIFPAQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQK
FRAERGRKGSTLPRGLHTNLEIMVVEP

Sequences:

>Translated_747_residues
MTNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKYKKSARTVGDVLGKFHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKIAEILLSELGQGTVDYQPNFDGTLAEPQY
LPARLPHILLNGTTGIAVGMATDIPPHNINEIADAAVMLLDNPKARLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGR
GSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIADQMTAKKLPMLEDIRDEADHENPIRIVLVPRSNRVDTDALMAHLF
ATTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLTFRRTTVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHE
DDPKAELMARFNLSDEQADAILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYASPR
MSQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHACGKSNQAVVFIDSTGRSYALD
PLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLMASDAGYGFICKFEDLIARNKTGKALISLPENAKVLKPKTL
INSTALVVAITSAGRMLIFPAQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQK
FRAERGRKGSTLPRGLHTNLEIMVVEP
>Mature_746_residues
TNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKYKKSARTVGDVLGKFHPH
GDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKIAEILLSELGQGTVDYQPNFDGTLAEPQYL
PARLPHILLNGTTGIAVGMATDIPPHNINEIADAAVMLLDNPKARLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGRG
SIKMRATWKKEDGEIIISALPHQSSPSKVIAQIADQMTAKKLPMLEDIRDEADHENPIRIVLVPRSNRVDTDALMAHLFA
TTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLTFRRTTVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHED
DPKAELMARFNLSDEQADAILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYASPRM
SQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHACGKSNQAVVFIDSTGRSYALDP
LSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLMASDAGYGFICKFEDLIARNKTGKALISLPENAKVLKPKTLI
NSTALVVAITSAGRMLIFPAQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQKF
RAERGRKGSTLPRGLHTNLEIMVVEP

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=728, Percent_Identity=71.2912087912088, Blast_Score=1100, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=647, Percent_Identity=36.1669242658423, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI212645845, Length=246, Percent_Identity=25.2032520325203, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=383, Percent_Identity=24.8041775456919, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83385; Mature: 83254

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNA
CCCCCCCCCHHCCHHHHHHHHHHCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCC
TAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLSKIAEILLSELGQGTVDYQPNFDGTLAEPQYLPARLPHILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEE
ATDIPPHNINEIADAAVMLLDNPKARLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGR
ECCCCCCCHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHCCC
GSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIADQMTAKKLPMLEDIRDEADHENPIR
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEE
IVLVPRSNRVDTDALMAHLFATTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLTFRRT
EEEEECCCCCCHHHHHHHHHHHCCCCCCEEECEEEEECCCCHHHHHHHHHHHHHHHHHHH
TVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHEDDPKAELMARFNLSDEQADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHEECCCCHHHHHH
ILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYASPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCHH
MSQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHAC
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHC
GKSNQAVVFIDSTGRSYALDPLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLM
CCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCHHHEE
ASDAGYGFICKFEDLIARNKTGKALISLPENAKVLKPKTLINSTALVVAITSAGRMLIFP
ECCCCCEEEEEHHHHHHCCCCCCEEEECCCCCCEECCHHHHCCCEEEEEEECCCEEEEEC
AQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQK
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHH
FRAERGRKGSTLPRGLHTNLEIMVVEP
HHHHCCCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
TNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNA
CCCCCCCCHHCCHHHHHHHHHHCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCC
TAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLSKIAEILLSELGQGTVDYQPNFDGTLAEPQYLPARLPHILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEE
ATDIPPHNINEIADAAVMLLDNPKARLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGR
ECCCCCCCHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHCCC
GSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIADQMTAKKLPMLEDIRDEADHENPIR
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEE
IVLVPRSNRVDTDALMAHLFATTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLTFRRT
EEEEECCCCCCHHHHHHHHHHHCCCCCCEEECEEEEECCCCHHHHHHHHHHHHHHHHHHH
TVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHEDDPKAELMARFNLSDEQADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHEECCCCHHHHHH
ILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYASPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCHH
MSQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHAC
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHC
GKSNQAVVFIDSTGRSYALDPLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLM
CCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCHHHEE
ASDAGYGFICKFEDLIARNKTGKALISLPENAKVLKPKTLINSTALVVAITSAGRMLIFP
ECCCCCEEEEEHHHHHHCCCCCCEEEECCCCCCEECCHHHHCCCEEEEEEECCCEEEEEC
AQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQK
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHH
FRAERGRKGSTLPRGLHTNLEIMVVEP
HHHHCCCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]