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The map label for this gene is bioF [C]

Identifier: 148826791

GI number: 148826791

Start: 28796

End: 29935

Strand: Direct

Name: bioF [C]

Synonym: CGSHiGG_00190

Alternate gene names: 148826791

Gene position: 28796-29935 (Clockwise)

Preceding gene: 148826790

Following gene: 148826792

Centisome position: 1.53

GC content: 39.56

Gene sequence:

>1140_bases
ATGGATGCTTTCAAACAGCAACTGGAACAGCTTAGCGCACAAAATCAATATCGTTCAATTCCAGATTTAGTTCATCAAGG
ACGATATATTATGCGAGAAAATCGCAAAATGCTGAATATGTCATCTAATGATTATTTAGGTTTGGCATCAAATGAAAACT
TGCGCCAGTCTTTTTTACAGCAATACGGCGGTAATTTCCCCTCTTTTACCAGTTCTTCATCGCGTTTATTAACGGGCAAC
TTTCCTATTTATACCGATTTGGAAGAGCTTGTCGCACAACGTTTCCAACGGGAAAGTGCGTTATTATTTAACAGCGGCTA
TCACGCCAATATCGGCATTTTGCCTGCTTTGACGACGAAAAGTTTGATTTTGGCAGATAAATTAGTGCATGCCAGCATGA
TTGATGGCATTCGTTTAAGCCAATGTGAGTTCTTTCGTTATCGTCATAATGATTATGAACATTTGAAAAATCTGCTTGAA
AAAAACGTCGGAAAATTTGACCGCACTTTTATCGTTACCGAATCTGTTTTCAGTATGGACGGCGACGTGGCGGATTTGAA
ACAGCTTGTTCAATTAAAAAAACAATTTCCCAATACTTATCTTTATGTGGATGAAGCCCATGCAATAGGCGTTTACGGTA
AAAACGGATTAGGTATTGCCGAACGAGCTAATGTGATAGCTGATATAGATTTGTTGGTTGGCACTTTTGGCAAGGCCTTA
GCTTCAATGGGGGCTTATGTCGTCTGTGATCAAATATTAAAAGAATGTTTGATTAATCAAATGCGCCCATTGATTTTTTC
AACCGCATTGCCGCCGTTTAATGTGGCTTGGACTTATTTTATTTTTGAACGATTGCCGCAATTCTCAAAAGAAAGAAGCC
ATCTTGAGCGGTTAAGTGCATTTTTACGCCAAGAAGTGGAACACAGAACGCAAATAATGCCAAGCCAAACTTGCATCGTT
CCCTATATTTTAGGCGAAAACGAAGCAACCCTTGCTAAGGCGAAAGATCTGCAAGAGCAAGGTTATTATTGTTTGCCAAT
CAGACCGCCGACAGTACCAAAAGGTACATCCAGAATACGATTGTCTTTGACGGCAGATATGACAATGGATGAAGTGAAAC
AGTTTGTGGCATGCTTATAA

Upstream 100 bases:

>100_bases
ATGTTATGCCACCATTTGTGATTAAAGATGATGAACTTCAGAAATTAACGGAAGGCATGATTTTGGCTTTAATTCAGGAA
TATGAACATTAGGATAAAAA

Downstream 100 bases:

>100_bases
GGAAATAATGTGAAAACGAAATTTTATGATCATCAAGGTGAGCATTTAATAGTTTATTTTGCTGGCTGGGGGACACCTCT
TGATGCTGTGGCTCATTTGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MDAFKQQLEQLSAQNQYRSIPDLVHQGRYIMRENRKMLNMSSNDYLGLASNENLRQSFLQQYGGNFPSFTSSSSRLLTGN
FPIYTDLEELVAQRFQRESALLFNSGYHANIGILPALTTKSLILADKLVHASMIDGIRLSQCEFFRYRHNDYEHLKNLLE
KNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGKNGLGIAERANVIADIDLLVGTFGKAL
ASMGAYVVCDQILKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLERLSAFLRQEVEHRTQIMPSQTCIV
PYILGENEATLAKAKDLQEQGYYCLPIRPPTVPKGTSRIRLSLTADMTMDEVKQFVACL

Sequences:

>Translated_379_residues
MDAFKQQLEQLSAQNQYRSIPDLVHQGRYIMRENRKMLNMSSNDYLGLASNENLRQSFLQQYGGNFPSFTSSSSRLLTGN
FPIYTDLEELVAQRFQRESALLFNSGYHANIGILPALTTKSLILADKLVHASMIDGIRLSQCEFFRYRHNDYEHLKNLLE
KNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGKNGLGIAERANVIADIDLLVGTFGKAL
ASMGAYVVCDQILKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLERLSAFLRQEVEHRTQIMPSQTCIV
PYILGENEATLAKAKDLQEQGYYCLPIRPPTVPKGTSRIRLSLTADMTMDEVKQFVACL
>Mature_379_residues
MDAFKQQLEQLSAQNQYRSIPDLVHQGRYIMRENRKMLNMSSNDYLGLASNENLRQSFLQQYGGNFPSFTSSSSRLLTGN
FPIYTDLEELVAQRFQRESALLFNSGYHANIGILPALTTKSLILADKLVHASMIDGIRLSQCEFFRYRHNDYEHLKNLLE
KNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGKNGLGIAERANVIADIDLLVGTFGKAL
ASMGAYVVCDQILKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLERLSAFLRQEVEHRTQIMPSQTCIV
PYILGENEATLAKAKDLQEQGYYCLPIRPPTVPKGTSRIRLSLTADMTMDEVKQFVACL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=382, Percent_Identity=30.6282722513089, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI284448556, Length=354, Percent_Identity=31.3559322033898, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=33.1412103746398, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=33.1412103746398, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=33.4293948126801, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI119220554, Length=381, Percent_Identity=27.0341207349081, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4758668, Length=252, Percent_Identity=32.9365079365079, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4502025, Length=337, Percent_Identity=28.7833827893175, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI40316939, Length=337, Percent_Identity=28.7833827893175, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI5454084, Length=253, Percent_Identity=25.6916996047431, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1786993, Length=357, Percent_Identity=35.5742296918768, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1790046, Length=380, Percent_Identity=31.5789473684211, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=387, Percent_Identity=32.2997416020672, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI32566772, Length=363, Percent_Identity=26.4462809917355, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560914, Length=172, Percent_Identity=37.2093023255814, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17560912, Length=172, Percent_Identity=37.2093023255814, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=259, Percent_Identity=27.7992277992278, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982617, Length=259, Percent_Identity=27.7992277992278, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=374, Percent_Identity=30.4812834224599, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320267, Length=355, Percent_Identity=27.6056338028169, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=283, Percent_Identity=28.2685512367491, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24662918, Length=353, Percent_Identity=33.9943342776204, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17137420, Length=365, Percent_Identity=30.1369863013699, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17136286, Length=365, Percent_Identity=27.3972602739726, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24653280, Length=288, Percent_Identity=27.0833333333333, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24653276, Length=288, Percent_Identity=27.0833333333333, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24653278, Length=288, Percent_Identity=27.0833333333333, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43171; Mature: 43171

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAFKQQLEQLSAQNQYRSIPDLVHQGRYIMRENRKMLNMSSNDYLGLASNENLRQSFLQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHCCCCCCCEEEECCCCHHHHHHHH
QYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANIGILPALTTK
HHCCCCCCCCCCCCEEEECCCCCEECHHHHHHHHHHHHHHEEEECCCCCCCEEEECHHHH
SLILADKLVHASMIDGIRLSQCEFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHCC
GDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGKNGLGIAERANVIADIDLLVGTFGKAL
CCHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASMGAYVVCDQILKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLERLSA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLRQEVEHRTQIMPSQTCIVPYILGENEATLAKAKDLQEQGYYCLPIRPPTVPKGTSRIR
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEE
LSLTADMTMDEVKQFVACL
EEEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MDAFKQQLEQLSAQNQYRSIPDLVHQGRYIMRENRKMLNMSSNDYLGLASNENLRQSFLQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHCCCCCCCEEEECCCCHHHHHHHH
QYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANIGILPALTTK
HHCCCCCCCCCCCCEEEECCCCCEECHHHHHHHHHHHHHHEEEECCCCCCCEEEECHHHH
SLILADKLVHASMIDGIRLSQCEFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHCC
GDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGKNGLGIAERANVIADIDLLVGTFGKAL
CCHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASMGAYVVCDQILKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLERLSA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLRQEVEHRTQIMPSQTCIVPYILGENEATLAKAKDLQEQGYYCLPIRPPTVPKGTSRIR
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEE
LSLTADMTMDEVKQFVACL
EEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA