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The map label for this gene is bioA [H]

Identifier: 148826790

GI number: 148826790

Start: 27498

End: 28787

Strand: Direct

Name: bioA [H]

Synonym: CGSHiGG_00185

Alternate gene names: 148826790

Gene position: 27498-28787 (Clockwise)

Preceding gene: 148826789

Following gene: 148826791

Centisome position: 1.46

GC content: 40.16

Gene sequence:

>1290_bases
ATGGATGAACAATCACTTTTAGCTTTTGATACACAACATATTTGGCATCCTTATTCTTCAGTTTCTTCTGATATGCCGCT
TTATGCGGTGGAACGTGCTGATGGCGTGATGATAACTTTAAAAGATGGTCGTCGTTTGATTGATGGTATGTCCTCTTGGT
GGGCGGCGTTGCACGGTTATAATCATCCTCGTTTAAATGCGGCGGCACAGAATCAATTAGCAAAAATGAGCCATATTATG
TTTGGCGGATTTACCCATGACCCTGCGGTGGAATTAGCTCAATTATTGGTACAAATTTTGCCCAATGGATTAGATAAGAT
CTTTTTTGCTGATAGTGGTTCTGTTGCAGTGGAAGTAGCGATGAAAATGGCTATTCAATATCAGCACGCTAAAGGAGAAG
TGCAACGACAAAAATTTGCCACTATTCGTTCTGGTTATCACGGCGATACTTGGAATGCAATGTCAGTGTGTGATCCAACC
ACAGGGATGCATCATTTATTTCATCATAGCCTGCCTGTACAATATTTTCTTCCTCAACCCAACATTCCATTTAATGAATC
TTGGAATGATTGTGTCATTGAACCTTTAGCTGATTTACTTGAACGAAAAGGTAATGAAATCGCCGCACTGATTTTAGAAC
CTGTTGTGCAAGGTGCAGGCGGTATGTATTTTTATTCGCCAACTTATTTAGTGAAAGCGCAAGCACTTTGTAAACAATAT
GGCGTTTTGCTGATTTTTGATGAAATCGCCACGGGATTTGGTCGAACAGGGAAATTATTTGCAGCTGAACACGCAGGCAT
TTCGCCAGATATTATGTGTATCGGTAAAGCATTAACGGGTGGTTATTTAACTTTATCGGCAAGTATTACGACCACTGAAA
TTGCGCAAATTATTTGTAGCGGTGAGGCTAAATGCTTTATGCACGGGCCCACTTTTATGGCAAACCCGTTGGCTTGTGCA
ATTGCAGCGGAATCTATCCGTTTATTGTTGGAAAGTCCTTGGCAGCAAAATATTCAGCGAATTGAGCATTCCTTAAAACA
ACAGCTTTCGCCTTTAGCTGAAAAAGATTACGTCAAAGAAGTTCGTGCATTAGGGGCGATTGGGGTGGTTGAAATGAAAA
GTGCGGTAAATATGAAAACTTTAGTTCCACGTTTTGTGGAACAAGGTGTTTGGATTCGACCTTTCGGAAAATTGGTTTAT
GTTATGCCACCATTTGTGATTAAAGATGATGAACTTCAGAAATTAACGGAAGGCATGATTTTGGCTTTAATTCAGGAATA
TGAACATTAG

Upstream 100 bases:

>100_bases
CGCTGTTACTTTCCTTGCTTTCAACCCTTTATCCTGCTTATCGAGCTGCGAAAGTAGAACCTGCAGCAGCTTTGAGATAC
GAGTAAATGGTAAATAAATG

Downstream 100 bases:

>100_bases
GATAAAAAATGGATGCTTTCAAACAGCAACTGGAACAGCTTAGCGCACAAAATCAATATCGTTCAATTCCAGATTTAGTT
CATCAAGGACGATATATTAT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHGYNHPRLNAAAQNQLAKMSHIM
FGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEVAMKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDPT
TGMHHLFHHSLPVQYFLPQPNIPFNESWNDCVIEPLADLLERKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQY
GVLLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQIICSGEAKCFMHGPTFMANPLACA
IAAESIRLLLESPWQQNIQRIEHSLKQQLSPLAEKDYVKEVRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLVY
VMPPFVIKDDELQKLTEGMILALIQEYEH

Sequences:

>Translated_429_residues
MDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHGYNHPRLNAAAQNQLAKMSHIM
FGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEVAMKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDPT
TGMHHLFHHSLPVQYFLPQPNIPFNESWNDCVIEPLADLLERKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQY
GVLLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQIICSGEAKCFMHGPTFMANPLACA
IAAESIRLLLESPWQQNIQRIEHSLKQQLSPLAEKDYVKEVRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLVY
VMPPFVIKDDELQKLTEGMILALIQEYEH
>Mature_429_residues
MDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHGYNHPRLNAAAQNQLAKMSHIM
FGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEVAMKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDPT
TGMHHLFHHSLPVQYFLPQPNIPFNESWNDCVIEPLADLLERKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQY
GVLLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQIICSGEAKCFMHGPTFMANPLACA
IAAESIRLLLESPWQQNIQRIEHSLKQQLSPLAEKDYVKEVRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLVY
VMPPFVIKDDELQKLTEGMILALIQEYEH

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=413, Percent_Identity=28.3292978208232, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI13994255, Length=371, Percent_Identity=30.188679245283, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI284507298, Length=315, Percent_Identity=29.8412698412698, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI37574042, Length=454, Percent_Identity=22.9074889867841, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI226442709, Length=398, Percent_Identity=23.6180904522613, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI226442705, Length=373, Percent_Identity=23.5924932975871, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI24119277, Length=411, Percent_Identity=25.7907542579075, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=57.6190476190476, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI145693181, Length=359, Percent_Identity=34.2618384401114, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789016, Length=411, Percent_Identity=27.9805352798054, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=28.463476070529, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=27.8325123152709, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787560, Length=417, Percent_Identity=28.537170263789, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786349, Length=266, Percent_Identity=31.203007518797, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=397, Percent_Identity=26.1964735516373, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=226, Percent_Identity=30.9734513274336, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=23.5981308411215, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17541228, Length=442, Percent_Identity=23.9819004524887, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=469, Percent_Identity=42.8571428571429, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=28.8782816229117, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324432, Length=386, Percent_Identity=25.6476683937824, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357415, Length=406, Percent_Identity=28.3251231527094, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21356575, Length=387, Percent_Identity=25.8397932816537, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=25.5813953488372, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161085790, Length=373, Percent_Identity=27.0777479892761, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281366494, Length=368, Percent_Identity=26.6304347826087, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667139, Length=368, Percent_Identity=26.6304347826087, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667143, Length=368, Percent_Identity=26.6304347826087, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47609; Mature: 47609

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHGY
CCCCCEEEECHHHHHCCHHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCC
NHPRLNAAAQNQLAKMSHIMFGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEVA
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
MKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDPTTGMHHLFHHSLPVQYFLPQP
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEECCCC
NIPFNESWNDCVIEPLADLLERKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQY
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHC
GVLLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQIICS
CEEEEEHHHHHCCCCCCCEEEECCCCCCCCCEEEEHHCCCCEEEEEECCHHHHHHHHHHC
GEAKCFMHGPTFMANPLACAIAAESIRLLLESPWQQNIQRIEHSLKQQLSPLAEKDYVKE
CCCEEEEECCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLVYVMPPFVIKDDELQKLTEGMI
HHHHCCCCHHHHHHHCCHHHHHHHHHHCCCEEEECCCEEEECCCEEECCHHHHHHHHHHH
LALIQEYEH
HHHHHHHCC
>Mature Secondary Structure
MDEQSLLAFDTQHIWHPYSSVSSDMPLYAVERADGVMITLKDGRRLIDGMSSWWAALHGY
CCCCCEEEECHHHHHCCHHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCC
NHPRLNAAAQNQLAKMSHIMFGGFTHDPAVELAQLLVQILPNGLDKIFFADSGSVAVEVA
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
MKMAIQYQHAKGEVQRQKFATIRSGYHGDTWNAMSVCDPTTGMHHLFHHSLPVQYFLPQP
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEECCCC
NIPFNESWNDCVIEPLADLLERKGNEIAALILEPVVQGAGGMYFYSPTYLVKAQALCKQY
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHC
GVLLIFDEIATGFGRTGKLFAAEHAGISPDIMCIGKALTGGYLTLSASITTTEIAQIICS
CEEEEEHHHHHCCCCCCCEEEECCCCCCCCCEEEEHHCCCCEEEEEECCHHHHHHHHHHC
GEAKCFMHGPTFMANPLACAIAAESIRLLLESPWQQNIQRIEHSLKQQLSPLAEKDYVKE
CCCEEEEECCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRALGAIGVVEMKSAVNMKTLVPRFVEQGVWIRPFGKLVYVMPPFVIKDDELQKLTEGMI
HHHHCCCCHHHHHHHCCHHHHHHHHHHCCCEEEECCCEEEECCCEEECCHHHHHHHHHHH
LALIQEYEH
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]