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The map label for this gene is hemK [H]

Identifier: 148826785

GI number: 148826785

Start: 22746

End: 23624

Strand: Direct

Name: hemK [H]

Synonym: CGSHiGG_00160

Alternate gene names: 148826785

Gene position: 22746-23624 (Clockwise)

Preceding gene: 148826784

Following gene: 148826786

Centisome position: 1.21

GC content: 41.07

Gene sequence:

>879_bases
ATGAATTATAAAGAATGGCTGGCACAAGCGATTGCGGATTTAGCACAAAAAAATCCCACTGAAAATAGTAAAATTGATGC
ACTTGTGCTTCTTCAACATGCTACTGGCAAATCGCGTACGCAAATCCTTGCTTTTGATGATACCGAGATTGATGAAAAAG
TGCGGTTAAAATTGACCGCACTTTTAGATCGTCGTCTAAAAGGCGAACCTATCGCTTATATTCTTGGCGAAAAAGAATTT
TGGTCGTTGCCATTAAATGTCTCAAAAGGCACATTGATTCCAAGACCAGACACGGAAAGTTTAGTGGAAAAAGCATTACA
AATTGCGTTAGAAAAACTGGAAGAAAATCCACCGCACTTTCGTATTCTTGATCTCGGCACTGGCACAGGCGCAATCGCCC
TCGCTTTGGCTTCCGAGCTTGCGCCCATTTGCCAAAAGCGGCATATTCCGCTGGAAATCATTGGTGTTGATCTTATGCCC
GATGTTGTGGCATTAGCTCAATCTAATGCAGAAAGAAATCAGCTAAATGTAGAATTTTTGCAGAGCCGTTGGTTTGATAA
TATAACAGGGAAGTTTGATCTTATCGTCAGCAATCCGCCTTATATTGATGCGCAAGATGAACATTTGCATCAAGGCGATG
TGCGTTTTGAACCCCTTTCTGCATTAGTTGCCAATGATGAGGGGTATGCTGATTTACGTCATATTATTGAATTAGCATCG
AGTTATTTGAATTCTAATGGCGTATTATTGCTTGAACACGGATGGCAACAAGGCGAAAAAGTGCGGTCAATTTTCCTAGA
AAATTATTGGGAAATGGTTGAAACCGTGCGTGATTATGGCGACAATGAGCGCGTCACTTTAGGTTTTTGGAAGAAGTAA

Upstream 100 bases:

>100_bases
TCTTATTGATTATTAGCGGTATTGTTGCACTTGTGCGCGATGATCGTCGTTCTTTAACTGATTTAGTGGCTGGCACGATT
GTGTTAAAAGACGAAAAATA

Downstream 100 bases:

>100_bases
TGAAATATTATCGACGTGCGTTATACGATAAATTTGTGCATTTTTATCTTGTGATCTCTGATGATGGCAGCTCAGAAGCA
CAACTTCGGGGAAAAATGGG

Product: hypothetical protein

Products: NA

Alternate protein names: M.HindHemKP [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MNYKEWLAQAIADLAQKNPTENSKIDALVLLQHATGKSRTQILAFDDTEIDEKVRLKLTALLDRRLKGEPIAYILGEKEF
WSLPLNVSKGTLIPRPDTESLVEKALQIALEKLEENPPHFRILDLGTGTGAIALALASELAPICQKRHIPLEIIGVDLMP
DVVALAQSNAERNQLNVEFLQSRWFDNITGKFDLIVSNPPYIDAQDEHLHQGDVRFEPLSALVANDEGYADLRHIIELAS
SYLNSNGVLLLEHGWQQGEKVRSIFLENYWEMVETVRDYGDNERVTLGFWKK

Sequences:

>Translated_292_residues
MNYKEWLAQAIADLAQKNPTENSKIDALVLLQHATGKSRTQILAFDDTEIDEKVRLKLTALLDRRLKGEPIAYILGEKEF
WSLPLNVSKGTLIPRPDTESLVEKALQIALEKLEENPPHFRILDLGTGTGAIALALASELAPICQKRHIPLEIIGVDLMP
DVVALAQSNAERNQLNVEFLQSRWFDNITGKFDLIVSNPPYIDAQDEHLHQGDVRFEPLSALVANDEGYADLRHIIELAS
SYLNSNGVLLLEHGWQQGEKVRSIFLENYWEMVETVRDYGDNERVTLGFWKK
>Mature_292_residues
MNYKEWLAQAIADLAQKNPTENSKIDALVLLQHATGKSRTQILAFDDTEIDEKVRLKLTALLDRRLKGEPIAYILGEKEF
WSLPLNVSKGTLIPRPDTESLVEKALQIALEKLEENPPHFRILDLGTGTGAIALALASELAPICQKRHIPLEIIGVDLMP
DVVALAQSNAERNQLNVEFLQSRWFDNITGKFDLIVSNPPYIDAQDEHLHQGDVRFEPLSALVANDEGYADLRHIIELAS
SYLNSNGVLLLEHGWQQGEKVRSIFLENYWEMVETVRDYGDNERVTLGFWKK

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=238, Percent_Identity=34.0336134453782, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1787463, Length=294, Percent_Identity=57.4829931972789, Blast_Score=305, Evalue=2e-84,
Organism=Escherichia coli, GI87082085, Length=188, Percent_Identity=32.9787234042553, Blast_Score=87, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324266, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582226, Length=276, Percent_Identity=24.6376811594203, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 33020; Mature: 33020

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKEWLAQAIADLAQKNPTENSKIDALVLLQHATGKSRTQILAFDDTEIDEKVRLKLTA
CCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHH
LLDRRLKGEPIAYILGEKEFWSLPLNVSKGTLIPRPDTESLVEKALQIALEKLEENPPHF
HHHHHCCCCCEEEEECCCHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
RILDLGTGTGAIALALASELAPICQKRHIPLEIIGVDLMPDVVALAQSNAERNQLNVEFL
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCHHHHHHHHH
QSRWFDNITGKFDLIVSNPPYIDAQDEHLHQGDVRFEPLSALVANDEGYADLRHIIELAS
HHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECHHHHEEECCCCHHHHHHHHHHHH
SYLNSNGVLLLEHGWQQGEKVRSIFLENYWEMVETVRDYGDNERVTLGFWKK
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MNYKEWLAQAIADLAQKNPTENSKIDALVLLQHATGKSRTQILAFDDTEIDEKVRLKLTA
CCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHH
LLDRRLKGEPIAYILGEKEFWSLPLNVSKGTLIPRPDTESLVEKALQIALEKLEENPPHF
HHHHHCCCCCEEEEECCCHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
RILDLGTGTGAIALALASELAPICQKRHIPLEIIGVDLMPDVVALAQSNAERNQLNVEFL
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCHHHHHHHHH
QSRWFDNITGKFDLIVSNPPYIDAQDEHLHQGDVRFEPLSALVANDEGYADLRHIIELAS
HHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECHHHHEEECCCCHHHHHHHHHHHH
SYLNSNGVLLLEHGWQQGEKVRSIFLENYWEMVETVRDYGDNERVTLGFWKK
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]