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The map label for this gene is licA [H]

Identifier: 148826776

GI number: 148826776

Start: 14934

End: 15914

Strand: Reverse

Name: licA [H]

Synonym: CGSHiGG_00115

Alternate gene names: 148826776

Gene position: 15914-14934 (Counterclockwise)

Preceding gene: 148826798

Following gene: 148826775

Centisome position: 0.84

GC content: 32.72

Gene sequence:

>981_bases
ATGCTATGCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAAT
CAATCAAATTGTAGGATTTGTTAAAACTTGCTACAAGCCTGAGGAAGTATTTCATTTTCTTCATCAGAATTCCATTCCTT
TTTCCTCCATTGGAGGAATGACCAATCAAAATGTTCTACTTAATATTTCTGGAATTAAGTTTGTATTACGGATCCCTAAT
GCCGTAAATTTATCACTTATAAATCGAGAATATGAGGCATTCAATAATGCTCAGGCATATCGTGCTGGCTTGAATGTAGA
AACTCCCGTATTAGATGCCAAAAGTGGCGTAAAACTAACTCGCTATTTAGAAAATAGTAAGCCGTTAAGTCAGATACAAT
TAAACGAACAAAGTTGTTTGTCTCAAGTTGTGAATAATTTATATCGTTTACACAATAGTGAATTTGTTTTTCGTAATGTA
TTTAGCGTATTCGATGAGTTTCGCCAATATTTTTCATTGCTAGAAAACAAATCCGCTTTTTATCAAGCTGATTCGAAAAT
GGATAAACTTTCAGCTGTATTTTGGCAATTTGAAGAAATCAATAAAGAGATAATTTTACGTCCGTGCCACAATGATTTAG
TCCCTGAAAATATGTTATTACAAGATGATCGGCTATTTTTTATTGATTGGGAATATTCGGGCTTAAATGATCCGCTATTT
GATATAGCTACTATCATTGAGGAAGCTCATTTATCGAAAGAAGCTGCTGATTTTCTATTAGAAACCTATTGCAATCAGAC
AAATAAATATCACAAGACAGAATTTCAAATCGCTCACAAACGGTTAAAAATCCATCGTTTTTGCCAAAATGTATTGTGGT
TTTTATGGACAAAAGTAAAAGAAGAACACGGCGAGAATTTTGGCGATTATGCGTTAAAACGCTTAGACGCAGCATTTAAA
CTGTTAGAGGAATTGCCATAA

Upstream 100 bases:

>100_bases
GGTTCAAAAGTTGAATAAATTCATAAGATTCAGAGCCTTACAAAAATAACTTTAACGTGTTAAAATCAAACAAAATTTAA
ATATAAAAATGAATACAAAA

Downstream 100 bases:

>100_bases
TGCGTGGCTATCTCTTTGGCATACTGTCCGCTGTATTTTGGGCATTATCTGGACTGTTGTATAATGAATTGCCATTAAGT
GAATATACCGCGTTAGGGAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MLCNQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQNSIPFSSIGGMTNQNVLLNISGIKFVLRIPN
AVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNV
FSVFDEFRQYFSLLENKSAFYQADSKMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLF
DIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAFK
LLEELP

Sequences:

>Translated_326_residues
MLCNQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQNSIPFSSIGGMTNQNVLLNISGIKFVLRIPN
AVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNV
FSVFDEFRQYFSLLENKSAFYQADSKMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLF
DIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAFK
LLEELP
>Mature_326_residues
MLCNQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQNSIPFSSIGGMTNQNVLLNISGIKFVLRIPN
AVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNV
FSVFDEFRQYFSLLENKSAFYQADSKMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLF
DIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAFK
LLEELP

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 38014; Mature: 38014

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCNQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQNSIPFSSIGGM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCC
TNQNVLLNISGIKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLT
CCCCEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHH
RYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAF
HHHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
YQADSKMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLF
HHHHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCCCCCEECCCCEEEEEEECCCCCCHHH
DIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEHGENFGDYALKRLDAAFKLLEELP
HHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLCNQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQNSIPFSSIGGM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCC
TNQNVLLNISGIKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLT
CCCCEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHH
RYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAF
HHHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
YQADSKMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLF
HHHHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCCCCCEECCCCEEEEEEECCCCCCHHH
DIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEHGENFGDYALKRLDAAFKLLEELP
HHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]