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The map label for this gene is galM [H]

Identifier: 148826537

GI number: 148826537

Start: 1579688

End: 1580710

Strand: Direct

Name: galM [H]

Synonym: CGSHiEE_07970

Alternate gene names: 148826537

Gene position: 1579688-1580710 (Clockwise)

Preceding gene: 148826536

Following gene: 148826538

Centisome position: 87.13

GC content: 39.0

Gene sequence:

>1023_bases
ATGTTAGAACAAACCACTTTTAATGCGCCTGATGGTGCACCTTATCAGCTTATAACCCTACAAAATGAAAATGGGATGCG
TGTTCAATTTCTGGATTGGGGCGCAACTTGGCTTTCTTGTAAAGTGCCAGTAAATGACACATTACGCGAGGTTTTATTGG
GTTGTAAGGTAGAGAATTATCCCACTCATCAAAGCTATTTAGGCGCAAGCGTAGGGCGTTATGCAAATCGTATTGCAAAT
GCACAATTTGAATTGAATGGCGAACTTATTAAATTAAGTAGTAATCAAGGAAAGCACCAGCTTCATGGTGGAGAGGGTTT
TGATAAACGCCGTTGGACAATCCAAAAGTGCGGTAAAAATTTTGTGTGTTTTTCATTACATTCAGAGCATGGCGATCAGG
GTTTTCCTGGTAATGTGGATGTGTCTGTAACCTATACGCTAACAGATGATAATAGCGTAAAAATTGAATATGCAGGGATT
TGTGATAAGGATACTGCATTGAACCTAACGAATCATGCTTATTTCAATTTAGAAAATGCAGCGCAAGGCAGTGACGTGCG
TGAACATACATTACGTTTAAATGCTGATTTTTATCTGCCTGTAGATAATGAGGGGATTCCTAATTCTCCATTAAAGCACG
TGGTGAATACAAGTTTTGACTTCCGTATTGCTAAACCCATCAAGCAAGATTTTTTACAAGGGGATCAGCAAGCAACAAAA
GGTTACGATCATTCCTTTATTGTCAATAAAGCTTGGCAAAAGCCTTGTGTGTTACTAACCTCTCCAACTGGCGATTTAAG
TTTGGAAGTAAGAACCTCGCAAGCTGCATTGCAGGTTTATACGGGTAATTATCTTGCAGGTACACCAACGAGAAATGGCG
AATTATATGCCGATTTTTCTGGCATAGCACTAGAAACCCAATGTTTACCAGATACGCCTAATCATCCTGAATGGCAAAAT
TACGGCGGAATTCAAAAAGCAAGCGAGCAATATTATCAATGGACAGAGTTTAAATTTAAATAA

Upstream 100 bases:

>100_bases
TAAAATTATTGCGGATAATTACGAGAAAACGACTGGTTTAAAAGAAACTTTTTATGTGTGTACCGCATCACAAGGTGTGC
GAGTGATTTAAGAGAAAATA

Downstream 100 bases:

>100_bases
ACCATTATTTATAATAAAAATGTCATTACAAGATCTATAAATTAGGTTCATTTCTAGCGTTAAAAGCAGTGACACACCAC
CAGCCTCTTAATCTAATTTA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFLDWGATWLSCKVPVNDTLREVLLGCKVENYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWTIQKCGKNFVCFSLHSEHGDQGFPGNVDVSVTYTLTDDNSVKIEYAGI
CDKDTALNLTNHAYFNLENAAQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKASEQYYQWTEFKFK

Sequences:

>Translated_340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFLDWGATWLSCKVPVNDTLREVLLGCKVENYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWTIQKCGKNFVCFSLHSEHGDQGFPGNVDVSVTYTLTDDNSVKIEYAGI
CDKDTALNLTNHAYFNLENAAQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKASEQYYQWTEFKFK
>Mature_340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFLDWGATWLSCKVPVNDTLREVLLGCKVENYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWTIQKCGKNFVCFSLHSEHGDQGFPGNVDVSVTYTLTDDNSVKIEYAGI
CDKDTALNLTNHAYFNLENAAQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKASEQYYQWTEFKFK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=324, Percent_Identity=37.6543209876543, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786971, Length=345, Percent_Identity=50.4347826086956, Blast_Score=334, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17557428, Length=306, Percent_Identity=31.3725490196078, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI115533334, Length=306, Percent_Identity=31.3725490196078, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6324399, Length=347, Percent_Identity=27.6657060518732, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322004, Length=357, Percent_Identity=28.0112044817927, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319493, Length=329, Percent_Identity=26.1398176291793, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24659048, Length=340, Percent_Identity=34.1176470588235, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24668278, Length=311, Percent_Identity=33.4405144694534, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24583720, Length=334, Percent_Identity=31.1377245508982, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24668282, Length=315, Percent_Identity=30.7936507936508, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24641876, Length=339, Percent_Identity=25.9587020648968, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38162; Mature: 38162

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQTTFNAPDGAPYQLITLQNENGMRVQFLDWGATWLSCKVPVNDTLREVLLGCKVENY
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCC
PTHQSYLGASVGRYANRIANAQFELNGELIKLSSNQGKHQLHGGEGFDKRRWTIQKCGKN
CCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCEEECCCCCCCCCCEEHHHCCCC
FVCFSLHSEHGDQGFPGNVDVSVTYTLTDDNSVKIEYAGICDKDTALNLTNHAYFNLENA
EEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCEEEECCCEEEEECCC
AQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
CCCCCCEEEEEEECCEEEEECCCCCCCCCHHHHHHCCCCCEEECCHHHHHHHCCCHHHHC
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFS
CCCCEEEEECCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCEEECCCCCCCEEEEECC
GIALETQCLPDTPNHPEWQNYGGIQKASEQYYQWTEFKFK
CEEEEEEECCCCCCCCCCCCCCCHHHHHHHHEEEEEEEEC
>Mature Secondary Structure
MLEQTTFNAPDGAPYQLITLQNENGMRVQFLDWGATWLSCKVPVNDTLREVLLGCKVENY
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCC
PTHQSYLGASVGRYANRIANAQFELNGELIKLSSNQGKHQLHGGEGFDKRRWTIQKCGKN
CCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCEEECCCCCCCCCCEEHHHCCCC
FVCFSLHSEHGDQGFPGNVDVSVTYTLTDDNSVKIEYAGICDKDTALNLTNHAYFNLENA
EEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCEEEECCCEEEEECCC
AQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
CCCCCCEEEEEEECCEEEEECCCCCCCCCHHHHHHCCCCCEEECCHHHHHHHCCCHHHHC
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFS
CCCCEEEEECCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCEEECCCCCCCEEEEECC
GIALETQCLPDTPNHPEWQNYGGIQKASEQYYQWTEFKFK
CEEEEEEECCCCCCCCCCCCCCCHHHHHHHHEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 1282642 [H]