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The map label for this gene is galK

Identifier: 148826536

GI number: 148826536

Start: 1578524

End: 1579678

Strand: Direct

Name: galK

Synonym: CGSHiEE_07965

Alternate gene names: 148826536

Gene position: 1578524-1579678 (Clockwise)

Preceding gene: 148826535

Following gene: 148826537

Centisome position: 87.07

GC content: 41.3

Gene sequence:

>1155_bases
ATGACCCCAATCCAAAATGCTCAACAAATTTTCAATAGACAGCATAAAAATTTGCCAGAAATTACCGTCTATGCCCCTGG
TCGAGTAAATATCATCGGCGAACATACCGATTACAACGACGGCTTTGTTATGCCTTGCGCAATTAATTTTGGTACGGCCA
TTTCTGGTGCAATACGAGATGATCATATTTGGAATGTTTATGCTGCAGATCTTGATGAAACTGATGAATTTTCTCTCAAT
GTTGAAATTCCTAAGAGTGAACACAAATGGGCCAATTACGTGCGTGGGGTGGTAAAATTTATCCAAGAACGTTACCCGCA
CTTTCAACAAGGTGCAAATTTAGTGATTTCTGGTAATGTGCCGCTTTCTTCAGGATTAAGTTCATCTGCAGCGTTAGAAG
TTGCGGTGGGTAAATTCTGCCAACAACTTGGCGATTTACCGCTTTCTCACACGGATATTGCATTGAATGGGCAAAAGGCT
GAAAACCAATTTGTTGGAGCAAATTGTGGCAATATGGATCAGTTAATTTCTGCGCTTGGGCAGGAAAATCACTTACTGAT
GATCGATTGTCGTAGTCTTGAAACCACGCCAACACCAGTGCCACAAGATGTCGCCGTGATTATTGTGAATTCAAACGTAC
CGCACGATTTAGTAACAGGCGAATACAATACTCGCCGTCAGCAATGTGAAGAGGCAGCAAAATTTTTTGGCGTGAAAGCA
TTACGAGATGTTTCAGTTGAGCAATTCCAAAAAAGAGAAGCAGAATTGACCGCACTTTCTCCGTTAGCAGCAAAACGTGC
TCGTCATGTCGTAACAGAAAATCAACGAGTACTTGATGCGGTAGAAGCATTGAAGAACAATGATTTGACTTGTTTAGGTA
AACTAATGGAAGCATCTCACGATTCAATGCGTGATGATTTTGAAATCACCGTACCACAAATTGATTATTTAGTTGAATTG
GTTCAACTTGTTATTGGCAAAAGTGGCGGTGCACGTATGACGGGCGGCGGTTTTGGTGGCTGTATTGTCGCACTTGCACC
GCATGATAAAGTCGATGCAGTTCGTAAAATTATTGCGGATAATTACGAGAAAACGACTGGTTTAAAAGAAACTTTTTATG
TGTGTACCGCATCACAAGGTGTGCGAGTGATTTAA

Upstream 100 bases:

>100_bases
CATTATAAAGAAAGAACTAAATAATATAGTCAGTTCCCCTCTTTAGCTTTAGCAAAGAGTGGTGCAGATCGAGTATAGAT
TTAATATAAAGGATAGAAAT

Downstream 100 bases:

>100_bases
GAGAAAATAATGTTAGAACAAACCACTTTTAATGCGCCTGATGGTGCACCTTATCAGCTTATAACCCTACAAAATGAAAA
TGGGATGCGTGTTCAATTTC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAISGAIRDDHIWNVYAADLDETDEFSLN
VEIPKSEHKWANYVRGVVKFIQERYPHFQQGANLVISGNVPLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKA
ENQFVGANCGNMDQLISALGQENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKA
LRDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASHDSMRDDFEITVPQIDYLVEL
VQLVIGKSGGARMTGGGFGGCIVALAPHDKVDAVRKIIADNYEKTTGLKETFYVCTASQGVRVI

Sequences:

>Translated_384_residues
MTPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAISGAIRDDHIWNVYAADLDETDEFSLN
VEIPKSEHKWANYVRGVVKFIQERYPHFQQGANLVISGNVPLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKA
ENQFVGANCGNMDQLISALGQENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKA
LRDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASHDSMRDDFEITVPQIDYLVEL
VQLVIGKSGGARMTGGGFGGCIVALAPHDKVDAVRKIIADNYEKTTGLKETFYVCTASQGVRVI
>Mature_383_residues
TPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAISGAIRDDHIWNVYAADLDETDEFSLNV
EIPKSEHKWANYVRGVVKFIQERYPHFQQGANLVISGNVPLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKAE
NQFVGANCGNMDQLISALGQENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKAL
RDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASHDSMRDDFEITVPQIDYLVELV
QLVIGKSGGARMTGGGFGGCIVALAPHDKVDAVRKIIADNYEKTTGLKETFYVCTASQGVRVI

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=393, Percent_Identity=41.7302798982188, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI48527957, Length=410, Percent_Identity=31.4634146341463, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4503897, Length=408, Percent_Identity=31.1274509803922, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1786972, Length=382, Percent_Identity=58.6387434554974, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71989053, Length=419, Percent_Identity=27.4463007159904, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320212, Length=246, Percent_Identity=27.2357723577236, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319494, Length=243, Percent_Identity=30.0411522633745, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24661292, Length=441, Percent_Identity=27.2108843537415, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355577, Length=441, Percent_Identity=27.2108843537415, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24661285, Length=441, Percent_Identity=27.2108843537415, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_HAEIE (A5UDQ5)

Other databases:

- EMBL:   CP000671
- RefSeq:   YP_001291289.1
- ProteinModelPortal:   A5UDQ5
- STRING:   A5UDQ5
- GeneID:   5225683
- GenomeReviews:   CP000671_GR
- KEGG:   hip:CGSHiEE_07965
- eggNOG:   COG0153
- HOGENOM:   HBG725121
- OMA:   YNDGFVM
- ProtClustDB:   PRK05101
- BioCyc:   HINF374930:CGSHIEE_07965-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 42135; Mature: 42004

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAISGAIRD
CCCCCHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECCCCHHCCCCCC
DHIWNVYAADLDETDEFSLNVEIPKSEHKWANYVRGVVKFIQERYPHFQQGANLVISGNV
CCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEECCC
PLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKAENQFVGANCGNMDQLISALG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHC
QENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKA
CCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHH
LRDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCC
DSMRDDFEITVPQIDYLVELVQLVIGKSGGARMTGGGFGGCIVALAPHDKVDAVRKIIAD
CCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCCHHHHHHHHHHHC
NYEKTTGLKETFYVCTASQGVRVI
CCHHHCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
TPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAISGAIRD
CCCCHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECCCCHHCCCCCC
DHIWNVYAADLDETDEFSLNVEIPKSEHKWANYVRGVVKFIQERYPHFQQGANLVISGNV
CCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEECCC
PLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKAENQFVGANCGNMDQLISALG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHC
QENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKA
CCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHH
LRDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCC
DSMRDDFEITVPQIDYLVELVQLVIGKSGGARMTGGGFGGCIVALAPHDKVDAVRKIIAD
CCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCCHHHHHHHHHHHC
NYEKTTGLKETFYVCTASQGVRVI
CCHHHCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA