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The map label for this gene is arcA [H]

Identifier: 148826471

GI number: 148826471

Start: 1511249

End: 1511959

Strand: Direct

Name: arcA [H]

Synonym: CGSHiEE_07610

Alternate gene names: 148826471

Gene position: 1511249-1511959 (Clockwise)

Preceding gene: 148826457

Following gene: 148826472

Centisome position: 83.35

GC content: 35.72

Gene sequence:

>711_bases
ATGACTACTCCAAAAATTCTCGTTGTTGAAGATGAAATTGTCACTCGAAATACGCTTAAAGGGATTTTTGAAGCGGAAGG
ATATGATGTGTTTGAAGCAGAAAATGGTGTTGAAATGCATCATATATTGGCAAATCATAATATTAATTTGGTTGTGATGG
ATATTAATTTACCAGGTAAAAACGGCTTATTATTGGCAAGAGAACTCCGTGAAGAATTAAGCTTACCTCTTATTTTTTTA
ACTGGTCGAGATAATGAAGTGGATAAAATTTTAGGTCTGGAAATTGGTGCCGACGATTATTTAACCAAACCTTTTAACCC
TAGAGAACTGACTATCCGCGCACGTAATCTATTGCATCGCACAATGTCGCATCAAGAAAAAGAAAATACATTTGGTCGAG
AATTCTATCGTTTTAATGGTTGGAAATTAGACCTAAATAGCCACAGTTTAATTACACCAGAAGGACAAGAATTCAAACTT
CCTCGCAGTGAATTTCGTGCAATGTTACATTTCTGTGAAAATCCAGGAAAATTGCAAACGCGCGAAGAATTGCTGAAAAA
AATGACGGGACGAGAGTTAAAACCTCAGGATCGTACCGTAGATGTCACAATTCGACGTATCAGAAAACATTTTGAAGATC
ATCCAAATACTCCAAATATCATTATGACTATACATGGAGAAGGCTATCGTTTTTGCGGAGATATTGAATAA

Upstream 100 bases:

>100_bases
CAGGTAAAAAATCACCGCACTTTTTTATTGTTACAATAATGTTGCACAGATAGAATGATAGCTTTGATAGCATACGCCAA
AATAAGTATAAGGATGGAAA

Downstream 100 bases:

>100_bases
AGTGATTGTTCTACATAAAAATTCCTTTTTGAAATTCATTTCCTGTTTTGTTAGAATTCGCACACTTTTCAATATCTAAT
GGAAAGTGAGTTCGGATGAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTTPKILVVEDEIVTRNTLKGIFEAEGYDVFEAENGVEMHHILANHNINLVVMDINLPGKNGLLLARELREELSLPLIFL
TGRDNEVDKILGLEIGADDYLTKPFNPRELTIRARNLLHRTMSHQEKENTFGREFYRFNGWKLDLNSHSLITPEGQEFKL
PRSEFRAMLHFCENPGKLQTREELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPNTPNIIMTIHGEGYRFCGDIE

Sequences:

>Translated_236_residues
MTTPKILVVEDEIVTRNTLKGIFEAEGYDVFEAENGVEMHHILANHNINLVVMDINLPGKNGLLLARELREELSLPLIFL
TGRDNEVDKILGLEIGADDYLTKPFNPRELTIRARNLLHRTMSHQEKENTFGREFYRFNGWKLDLNSHSLITPEGQEFKL
PRSEFRAMLHFCENPGKLQTREELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPNTPNIIMTIHGEGYRFCGDIE
>Mature_235_residues
TTPKILVVEDEIVTRNTLKGIFEAEGYDVFEAENGVEMHHILANHNINLVVMDINLPGKNGLLLARELREELSLPLIFLT
GRDNEVDKILGLEIGADDYLTKPFNPRELTIRARNLLHRTMSHQEKENTFGREFYRFNGWKLDLNSHSLITPEGQEFKLP
RSEFRAMLHFCENPGKLQTREELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPNTPNIIMTIHGEGYRFCGDIE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=77.6371308016878, Blast_Score=382, Evalue=1e-108,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=40.6926406926407, Blast_Score=186, Evalue=9e-49,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=35.4978354978355, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=35.0649350649351, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788394, Length=238, Percent_Identity=31.5126050420168, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=34.9557522123894, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=32.5991189427313, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=32.1739130434783, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=31.8777292576419, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=30.1310043668122, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=31.7180616740088, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=27.7777777777778, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790552, Length=234, Percent_Identity=31.6239316239316, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=27.4336283185841, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=31.8965517241379, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27445; Mature: 27314

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPKILVVEDEIVTRNTLKGIFEAEGYDVFEAENGVEMHHILANHNINLVVMDINLPGK
CCCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECCCCEEEEEEEECCCC
NGLLLARELREELSLPLIFLTGRDNEVDKILGLEIGADDYLTKPFNPRELTIRARNLLHR
CCEEEHHHHHHHCCCCEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMSHQEKENTFGREFYRFNGWKLDLNSHSLITPEGQEFKLPRSEFRAMLHFCENPGKLQT
HHHHHHHHHHHHHHHEEECCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCH
REELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPNTPNIIMTIHGEGYRFCGDIE
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEECCCC
>Mature Secondary Structure 
TTPKILVVEDEIVTRNTLKGIFEAEGYDVFEAENGVEMHHILANHNINLVVMDINLPGK
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECCCCEEEEEEEECCCC
NGLLLARELREELSLPLIFLTGRDNEVDKILGLEIGADDYLTKPFNPRELTIRARNLLHR
CCEEEHHHHHHHCCCCEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMSHQEKENTFGREFYRFNGWKLDLNSHSLITPEGQEFKLPRSEFRAMLHFCENPGKLQT
HHHHHHHHHHHHHHHEEECCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCH
REELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPNTPNIIMTIHGEGYRFCGDIE
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]