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The map label for this gene is emrA [H]

Identifier: 148826457

GI number: 148826457

Start: 1492102

End: 1493274

Strand: Direct

Name: emrA [H]

Synonym: CGSHiEE_07520

Alternate gene names: 148826457

Gene position: 1492102-1493274 (Clockwise)

Preceding gene: 148826456

Following gene: 148826471

Centisome position: 82.3

GC content: 37.94

Gene sequence:

>1173_bases
ATGACGAAAACTGCAATTGAAACTCCATCAAATAAATCTGTATCAAAGAAAACTAATCGTAAAAAAAATTTAAGCATTTT
TATTTTTATCTTGCTTATTATTGGTATTGCTTGTGCTTTGTATTGGTTTTTCTTCTTGAAGGATTTTGAAGAAACAGAAG
ATGCTTATGTGGGCGGTAATCAAGTGATGGTGTCATCACAAGTTGCAGGTAATGTAGCGAAGATTAATGCTGACAATATG
GATAAAGTCCATGCAGGTGATATTCTAGTTGAATTGGATGATACGAATGCGAAACTTAGTTTCGAACAGGCCAAAAGCAA
TCTCGCCAATGCTGTACGTCAGGTAGAACAACTCGGTTTCACTGTGCAACAATTGCAATCAGCTGTGCACGCCAATGAAA
TTTCTTTAGCTCAAGCACAAGGCAATTTGGCTCGCCGAGTTCAACTTGAAAAAATGGGTGCGATTGATAAAGAATCTTTC
CAACACGCAAAAGAAGCTGTCGAGCTTGCCAAAGCAAATTTAAATGCCTCTAAAAATCAATTGGCTGCTAATCAGGCTTT
ATTGAGTAACGTTCCATTACGTGAACAACCGCAAATACAGAATGCAATGAGTTCACTCAAACAGGCTTGGTTGAATTTAC
AACGTACAAAAATTAGAAGTCCAATTGATGGCTATGTGGCGCGTCGTAATGTTCAAGTTGGGCAAGCCGTTTCAGTGGGT
GGCGCGTTAATGGCAGTGGTATCTAATGAACAAATGTGGCTAGAAGCTAACTTCAAAGAAACCCAATTAACGAATATGCG
CATTGGTCAGCCAGTAAAAATCCATTTTGATTTATACGGTAAAAATAAAGAATTTGATGGCGTGATAAATGGTATTGAAA
TGGGGACTGGCAATGCATTTTCTCTTTTGCCTTCACAAAATGCTACGGGTAACTGGATTAAAGTGGTGCAACGCGTACCT
GTGCGAATTAAATTAGATCCACAACAATTTACAGAAACGCCATTGAGAATTGGTCTTTCTGCAACGGCAAAAGTAAGAAT
TTCAGATTCATCAGGCGCAATGCTACGAGAAAAAGCAGAACCGAAAACGTTATTTTCTACTGATACACTTAAATATGATG
AAAGTGCGGTAGAAAATTTGATTGAATCTATCATTCAGCAAAACAGCCATTAA

Upstream 100 bases:

>100_bases
TGAGTTCCCCTTTTTAAAGTTTCATAATGACCTTTCATTTTATTTTTGATAGTTTTAAATATCCCATTTTTAAACATTAT
CCCAAATCAGGGAAGACATT

Downstream 100 bases:

>100_bases
GGCGGCATTATGGACAATTCCGCAAAAAAATTCCCGCCTATTCAAGGTGGTGCGCTGATTTTATTAACGCTGGCTTTATC
TCTTGCCACCTTTATGCAGG

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTKTAIETPSNKSVSKKTNRKKNLSIFIFILLIIGIACALYWFFFLKDFEETEDAYVGGNQVMVSSQVAGNVAKINADNM
DKVHAGDILVELDDTNAKLSFEQAKSNLANAVRQVEQLGFTVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESF
QHAKEAVELAKANLNASKNQLAANQALLSNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVG
GALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAFSLLPSQNATGNWIKVVQRVP
VRIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKAEPKTLFSTDTLKYDESAVENLIESIIQQNSH

Sequences:

>Translated_390_residues
MTKTAIETPSNKSVSKKTNRKKNLSIFIFILLIIGIACALYWFFFLKDFEETEDAYVGGNQVMVSSQVAGNVAKINADNM
DKVHAGDILVELDDTNAKLSFEQAKSNLANAVRQVEQLGFTVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESF
QHAKEAVELAKANLNASKNQLAANQALLSNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVG
GALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAFSLLPSQNATGNWIKVVQRVP
VRIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKAEPKTLFSTDTLKYDESAVENLIESIIQQNSH
>Mature_389_residues
TKTAIETPSNKSVSKKTNRKKNLSIFIFILLIIGIACALYWFFFLKDFEETEDAYVGGNQVMVSSQVAGNVAKINADNMD
KVHAGDILVELDDTNAKLSFEQAKSNLANAVRQVEQLGFTVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESFQ
HAKEAVELAKANLNASKNQLAANQALLSNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVGG
ALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAFSLLPSQNATGNWIKVVQRVPV
RIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKAEPKTLFSTDTLKYDESAVENLIESIIQQNSH

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=383, Percent_Identity=46.7362924281984, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1788711, Length=382, Percent_Identity=47.6439790575916, Blast_Score=344, Evalue=5e-96,
Organism=Escherichia coli, GI1790519, Length=308, Percent_Identity=28.8961038961039, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87081951, Length=311, Percent_Identity=26.3665594855305, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789637, Length=339, Percent_Identity=26.2536873156342, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43059; Mature: 42928

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTAIETPSNKSVSKKTNRKKNLSIFIFILLIIGIACALYWFFFLKDFEETEDAYVGGN
CCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
QVMVSSQVAGNVAKINADNMDKVHAGDILVELDDTNAKLSFEQAKSNLANAVRQVEQLGF
EEEEEHHHCCCEEEECCCCCCCEECCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCH
TVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESFQHAKEAVELAKANLNASKNQ
HHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHH
LAANQALLSNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHC
GALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAF
CEEEEEECCCEEEEECCCCHHEECCCCCCCCEEEEEEEECCCCCCCHHHCCEEECCCCEE
SLLPSQNATGNWIKVVQRVPVRIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKAE
EECCCCCCCCHHHHHHHHCCEEEEECHHHHHCCCHHCCCCCEEEEEEECCCCCHHHHCCC
PKTLFSTDTLKYDESAVENLIESIIQQNSH
CCEEEECCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKTAIETPSNKSVSKKTNRKKNLSIFIFILLIIGIACALYWFFFLKDFEETEDAYVGGN
CCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
QVMVSSQVAGNVAKINADNMDKVHAGDILVELDDTNAKLSFEQAKSNLANAVRQVEQLGF
EEEEEHHHCCCEEEECCCCCCCEECCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCH
TVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESFQHAKEAVELAKANLNASKNQ
HHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHH
LAANQALLSNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHC
GALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAF
CEEEEEECCCEEEEECCCCHHEECCCCCCCCEEEEEEEECCCCCCCHHHCCEEECCCCEE
SLLPSQNATGNWIKVVQRVPVRIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKAE
EECCCCCCCCHHHHHHHHCCEEEEECHHHHHCCCHHCCCCCEEEEEEECCCCCHHHHCCC
PKTLFSTDTLKYDESAVENLIESIIQQNSH
CCEEEECCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]