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The map label for this gene is lpxB [H]

Identifier: 148826325

GI number: 148826325

Start: 1341905

End: 1343077

Strand: Direct

Name: lpxB [H]

Synonym: CGSHiEE_06780

Alternate gene names: 148826325

Gene position: 1341905-1343077 (Clockwise)

Preceding gene: 148826324

Following gene: 148826326

Centisome position: 74.01

GC content: 40.15

Gene sequence:

>1173_bases
ATGAACAAAACAAATCCAACCATTGCTCTTGTTGCAGGAGAAGTGTCTGGCGATATTCTCGGGGCGGGATTAATACGCCA
GCTCAAAGCACATTATCCTAATGCGCGCTTTATTGGCATTGCAGGCCCAAGAATGTTGGCTGAAGGTTGTGAGACGCTTG
TTGATATGGAAGAGCTTTCAGTCATGGGCTTGGCTGAAATATTAAAACATCTTCCTCGTCTGTTGAAAATTCGCAAAAAT
ATCATTCAAACTATGTTGCAAGAAAAACCTGATGTTTACATCGGCATTGATGCACCTGATTTTAATTTGGATGTAGAACT
TAAACTAAAAGCGAACGGAATTAAAACTATTCATTACGTGAGCCCCTCTGTATGGGCTTGGCGTCAAAATCGCATCCATA
AAATTGCCAAAGCGACCCATCAAGTTCTAGCCTTTTTGCCTTTTGAGAAAGCCTTTTACGATAAATTTAATGTGCCTTGC
CGTTTTATTGGGCACACAATGGCAGATGCTATTCCGCTCAAACCAAACCGTGCCGAAGCCTGCCAAACGTTACAGATTGA
TCCCGCACAACGCTATTTAGCAATCTTAGTTGGAAGCCGTGGTTCAGAAGTGGAATTTCTAGCTGAGCCTTTCTTAAAAA
CCGCTTTATTATTAAAAGAACAATTCCCAGATTTACAATTTCTCGTGCCTTTAGTGAACGAAAAACGACGAATTCAATTT
GAAGCCATTAAAGCTAAAATTACGCCAAATCTAGACCTGCATTTAATTGATGGCAATGCACGACAAGCAATGATCGCCGC
TGATGCAACATTGCTTGCTTCAGGAACAGCAGCACTTGAAGCCATGCTTTGTAAATCACCCATGGTAGTTGGCTATCGAA
TGAAACCACTGACCTATTTCTTAGCAAAACGTTTAGTGAAAACCGATTATATTTCTTTACCAAACTTGCTTGCGAATGAA
ATGCTTGTTCCTGAAATGATTCAAGAAGAATGCACGCCAGAATTGCTTGCTGAAAAACTATCAGTTTATCTTTCTGATGA
TGAAAGTGCGGTAAAAAATCGCCATGTTTTAATTCAGCACTTCACGGATTTACACCAAAAAATTCAATGCAATGCCGATA
AGCAAGCGGCTCAAGCCGTCATTGATTTATTAGAAGGAACAGAAAATGTTTGA

Upstream 100 bases:

>100_bases
TTTCAAACGTTCAACTCGCGGGATTATTCGTTAATAAAACTTCTCCATTTTCAACCGCACTTTACACACCAAAGTGCGGT
TATTTTTTAGGATAAATTTG

Downstream 100 bases:

>100_bases
ATATCCACAAGGCTATAAATTGATCGCTGGCGTTGATGAAGTTGGGCGAGGCCCTCTAGTTGGGGCGGTTGTCACGGCAG
CCGTCATTTTAGATCCTCAT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELSVMGLAEILKHLPRLLKIRKN
IIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
EAIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGTENV

Sequences:

>Translated_390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELSVMGLAEILKHLPRLLKIRKN
IIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
EAIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGTENV
>Mature_390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELSVMGLAEILKHLPRLLKIRKN
IIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
EAIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGTENV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=384, Percent_Identity=63.28125, Blast_Score=491, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43595; Mature: 43595

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELS
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHH
VMGLAEILKHLPRLLKIRKNIIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCEEEEEEE
SPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPCRFIGHTMADAIPLKPNRAEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHH
CQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
HHEEECCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHEEE
EAIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYF
EEEEEEECCCCEEEEECCCCCEEEEEECHHHHHCCHHHHHHHHHCCCCEEEEECHHHHHH
LAKRLVKTDYISLPNLLANEMLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHHHHHHHH
FTDLHQKIQCNADKQAAQAVIDLLEGTENV
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELS
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHH
VMGLAEILKHLPRLLKIRKNIIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCEEEEEEE
SPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPCRFIGHTMADAIPLKPNRAEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHH
CQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
HHEEECCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHEEE
EAIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYF
EEEEEEECCCCEEEEECCCCCEEEEEECHHHHHCCHHHHHHHHHCCCCEEEEECHHHHHH
LAKRLVKTDYISLPNLLANEMLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHHHHHHHH
FTDLHQKIQCNADKQAAQAVIDLLEGTENV
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA