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The map label for this gene is lpxA [H]

Identifier: 148826324

GI number: 148826324

Start: 1341050

End: 1341838

Strand: Direct

Name: lpxA [H]

Synonym: CGSHiEE_06775

Alternate gene names: 148826324

Gene position: 1341050-1341838 (Clockwise)

Preceding gene: 148826323

Following gene: 148826325

Centisome position: 73.97

GC content: 40.3

Gene sequence:

>789_bases
ATGATCCACCCAAGTGCAAAAATTCATCCAACTGCCCTCATTGAAGAAGGTGCGGTAATTGGCGAAGATGTTTTTATTGG
ACCTTTCTGTATTGTTGAGGGTACTGTTGAAATTAAAGCTCGTACTGTATTGAAATCTCACGTTGTGGTACGTGGCGATA
CCGTGATTGGCGAAGATAATGAAATCTATCAATTCACTAGTATTGGCGAAGTAAACCAAGATTTGAAATACAAAGGCGAA
GCTACAAAAACCATTATTGGTAATAGCAATAAAATTCGTGAACACGTGACAATCCATCGTGGCACGATTCAAGGCTGTGG
CGTAACCGCTATTGGCAATAACAATTTATTAATGATTAATGTTCACGTTGCGCACGATTGCCAAATTAAAAATAACTGTA
TTCTGGCAAACAATGCAACGCTTGCAGGTCACGTAGAATTAGATGATTTCGTGATTGTTGGCGGTATGTCAGCAATTCAT
CAATTTGTGATTGTTGGCGCACATGTTATGTTAGGCGGCGGTTCTATGGTAAGCCAAGATGTACCACCTTATGTTATGGC
GCAAGGCAACCACGCCCGCCCATTTGGCGTAAACTTAGAGGGTTTGAAACGTCGTGGTTTTGATAAACCAACTATGCACG
CAATCCGTAACATTTATAAAATGATCTACCGTAGCGGTAAAACACTTGAAGAAGTGTTACCAGAAATTGAGCAAATTGCG
GAAACCGATTCAGCGATCAGTTTTTTTGTTGAATTTTTCAAACGTTCAACTCGCGGGATTATTCGTTAA

Upstream 100 bases:

>100_bases
CGCCGTGGTATTACTGCATTTACTGGCGTTGCCACCGTAAACGGCGAAATCGCTTGTGAAGCAAAACTAATGTGTGCTCG
TCGTTAATTAAGGGGTAAAT

Downstream 100 bases:

>100_bases
TAAAACTTCTCCATTTTCAACCGCACTTTACACACCAAAGTGCGGTTATTTTTTAGGATAAATTTGATGAACAAAACAAA
TCCAACCATTGCTCTTGTTG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIHPSAKIHPTALIEEGAVIGEDVFIGPFCIVEGTVEIKARTVLKSHVVVRGDTVIGEDNEIYQFTSIGEVNQDLKYKGE
ATKTIIGNSNKIREHVTIHRGTIQGCGVTAIGNNNLLMINVHVAHDCQIKNNCILANNATLAGHVELDDFVIVGGMSAIH
QFVIVGAHVMLGGGSMVSQDVPPYVMAQGNHARPFGVNLEGLKRRGFDKPTMHAIRNIYKMIYRSGKTLEEVLPEIEQIA
ETDSAISFFVEFFKRSTRGIIR

Sequences:

>Translated_262_residues
MIHPSAKIHPTALIEEGAVIGEDVFIGPFCIVEGTVEIKARTVLKSHVVVRGDTVIGEDNEIYQFTSIGEVNQDLKYKGE
ATKTIIGNSNKIREHVTIHRGTIQGCGVTAIGNNNLLMINVHVAHDCQIKNNCILANNATLAGHVELDDFVIVGGMSAIH
QFVIVGAHVMLGGGSMVSQDVPPYVMAQGNHARPFGVNLEGLKRRGFDKPTMHAIRNIYKMIYRSGKTLEEVLPEIEQIA
ETDSAISFFVEFFKRSTRGIIR
>Mature_262_residues
MIHPSAKIHPTALIEEGAVIGEDVFIGPFCIVEGTVEIKARTVLKSHVVVRGDTVIGEDNEIYQFTSIGEVNQDLKYKGE
ATKTIIGNSNKIREHVTIHRGTIQGCGVTAIGNNNLLMINVHVAHDCQIKNNCILANNATLAGHVELDDFVIVGGMSAIH
QFVIVGAHVMLGGGSMVSQDVPPYVMAQGNHARPFGVNLEGLKRRGFDKPTMHAIRNIYKMIYRSGKTLEEVLPEIEQIA
ETDSAISFFVEFFKRSTRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=68.7022900763359, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28700; Mature: 28700

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHPSAKIHPTALIEEGAVIGEDVFIGPFCIVEGTVEIKARTVLKSHVVVRGDTVIGEDN
CCCCCCCCCHHHEEECCCEECCCEEECCEEEEECEEEEEEEEEEEEEEEEECCEEECCCC
EIYQFTSIGEVNQDLKYKGEATKTIIGNSNKIREHVTIHRGTIQGCGVTAIGNNNLLMIN
CEEEEECCCCCCCCCEECCCCEEEEECCCCHHEEEEEEECCEECCCCEEEECCCCEEEEE
VHVAHDCQIKNNCILANNATLAGHVELDDFVIVGGMSAIHQFVIVGAHVMLGGGSMVSQD
EEEEECEEECCCEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHEEEECCCCCCCCC
VPPYVMAQGNHARPFGVNLEGLKRRGFDKPTMHAIRNIYKMIYRSGKTLEEVLPEIEQIA
CCCEEEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ETDSAISFFVEFFKRSTRGIIR
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIHPSAKIHPTALIEEGAVIGEDVFIGPFCIVEGTVEIKARTVLKSHVVVRGDTVIGEDN
CCCCCCCCCHHHEEECCCEECCCEEECCEEEEECEEEEEEEEEEEEEEEEECCEEECCCC
EIYQFTSIGEVNQDLKYKGEATKTIIGNSNKIREHVTIHRGTIQGCGVTAIGNNNLLMIN
CEEEEECCCCCCCCCEECCCCEEEEECCCCHHEEEEEEECCEECCCCEEEECCCCEEEEE
VHVAHDCQIKNNCILANNATLAGHVELDDFVIVGGMSAIHQFVIVGAHVMLGGGSMVSQD
EEEEECEEECCCEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHEEEECCCCCCCCC
VPPYVMAQGNHARPFGVNLEGLKRRGFDKPTMHAIRNIYKMIYRSGKTLEEVLPEIEQIA
CCCEEEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ETDSAISFFVEFFKRSTRGIIR
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA