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The map label for this gene is grxA

Identifier: 148826058

GI number: 148826058

Start: 1053834

End: 1054097

Strand: Direct

Name: grxA

Synonym: CGSHiEE_05240

Alternate gene names: 148826058

Gene position: 1053834-1054097 (Clockwise)

Preceding gene: 148826056

Following gene: 148826060

Centisome position: 58.13

GC content: 36.74

Gene sequence:

>264_bases
ATGTTCGTTGTTATTTTTGGTCGTCCTGGCTGCCCTTACTGTGTGCGTGCAAAAAACCTTGCTGAAAAATTAAAAGGCGA
AGTTGCTGATTTTGACTATCGTTATGTGGATATTCATGCAGAAGGCATTACTAAAGAAGATTTATCAAAATCAGTTGGTA
AGCCAGTAGAAACCGTACCACAAATCTTTATTGATGAAAAACCAATTGGTGGTTGCACTGACTTTGAAGCATTAATGAAA
GAACAATTTGGTATCGTTGCTTAA

Upstream 100 bases:

>100_bases
TCTACGATGTTCCGTATATTACACGAATAAAAACACTTTATGTAGACGATAAAAATCAGGTAGAATTGCCTAGAATGTTT
AACTCAAAAAAGGAAATCTT

Downstream 100 bases:

>100_bases
TTTTTCTTTTAATTTACAAAAAAGCCACTTTCAATCGAAAGTGGCTTTTTCATAGAATCGTTTTAACCGTTATAACGTTT
AAAAATTAATGTCGCATTTG

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: NA

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MFVVIFGRPGCPYCVRAKNLAEKLKGEVADFDYRYVDIHAEGITKEDLSKSVGKPVETVPQIFIDEKPIGGCTDFEALMK
EQFGIVA

Sequences:

>Translated_87_residues
MFVVIFGRPGCPYCVRAKNLAEKLKGEVADFDYRYVDIHAEGITKEDLSKSVGKPVETVPQIFIDEKPIGGCTDFEALMK
EQFGIVA
>Mature_87_residues
MFVVIFGRPGCPYCVRAKNLAEKLKGEVADFDYRYVDIHAEGITKEDLSKSVGKPVETVPQIFIDEKPIGGCTDFEALMK
EQFGIVA

Specific function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain

Homologues:

Organism=Escherichia coli, GI1787073, Length=83, Percent_Identity=69.8795180722892, Blast_Score=123, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLRX_HAEIN (P45242)

Other databases:

- EMBL:   L42023
- PIR:   I64127
- RefSeq:   NP_439681.1
- ProteinModelPortal:   P45242
- SMR:   P45242
- GeneID:   950394
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1532
- TIGR:   HI_1532
- HOGENOM:   HBG728471
- OMA:   VGGCTEF
- ProtClustDB:   PRK11200
- BioCyc:   HINF71421:HI_1532-MONOMER
- GO:   GO:0005737
- GO:   GO:0006810
- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PRINTS:   PR00160
- TIGRFAMs:   TIGR02183

Pfam domain/function: PF00462 Glutaredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 9670; Mature: 9670

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00195 GLUTAREDOXIN_1; PS51354 GLUTAREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVVIFGRPGCPYCVRAKNLAEKLKGEVADFDYRYVDIHAEGITKEDLSKSVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFIDEKPIGGCTDFEALMKEQFGIVA
HHHCCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MFVVIFGRPGCPYCVRAKNLAEKLKGEVADFDYRYVDIHAEGITKEDLSKSVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFIDEKPIGGCTDFEALMKEQFGIVA
HHHCCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800