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The map label for this gene is mutL [H]

Identifier: 148825659

GI number: 148825659

Start: 601804

End: 603963

Strand: Direct

Name: mutL [H]

Synonym: CGSHiEE_02995

Alternate gene names: 148825659

Gene position: 601804-603963 (Clockwise)

Preceding gene: 148825650

Following gene: 148825660

Centisome position: 33.19

GC content: 38.7

Gene sequence:

>2160_bases
TTGAGTTTATTACAACAAGCTCAAAATATTACCGCTCAAAAGCAAGTGGTAACTTTTAAGATTCAAGAAATTTTGCACCA
ACAGGATTATCAAACGCTTATCGCCACAGCAACATTGGCGAATAATTTGCAAGAACAACGAATTTTCTTAAATTGGAAAG
CGAAAGAGGTGCCTCAATTATCGGAAATTTGGCAAGCTGAAATTTCTTTACGTCCCCTTTCTGCGCGATTAAATTTCGGT
GGGTTTGATCGGCAACAATGGTATTTTTCAAAAGGAATTACGGCTGTTGGAACGGTAAAAAGTGCGGTGAAAATTGCGGA
TGTTTCATCATTGCGAGCAGAAAAATTGCAACAAGTGAAAAAACAAACAGAAGGGTTGTCCTTACAAGGTTTATTGATTG
CCTTAGCTTTTGGCGAACGGGCTTGGTTAGATAAAACCACTTGGTCAATTTACCAACAAAGCAATACCGCGCATCTTATT
GCTATTTCTGGCTTACATATTGGGTTGGCTATGGGGATTGGATTTTACTTGGCGCGTGTTGTGCAAGTATTTTTCCCCAC
CCGTTTTATTCATCCTTATTTTCCTTTAGCTTTTGGTGTTTTATTTGCTTTAATTTATGCGTATTTGGCTGGTTTTAGCG
TGCCAACTTTTCGTGCCATTTCAGCACTTGTTTTCGTTTTATTTATTCAAATAATGAGGCGACATTATTCGCCCCTTCAG
CTTTTTACGGTGGTTGTCGGATTCTTGCTTTTCTGCAATCCATTAATGCCGCTTTCGGTCAGTTTTTGGCTTTCTTGTGA
GGCAGTTGGGTGTTTGATCCTCTGGTATCGTTATGTGCCTTTTTCACTTTTTCAATGGAAAAATCGCCCCTTTTCACCAA
AAGTGCGGTGGATTTTGAGTTTATTTCATTTGCAATTTGGGTTATTGCTCTTTTTTACACCTTTGCAACTTTTTCTATTT
AATGGCTTATCGTTGAGTGGATTTTTAGCCAATCTTATGGCGGTTCCAATTTATAGTTTTTTGCTTGTGCCATTAATTTT
ATTTGCCGTTTTTACTAACGGCACAATGTTTTTTTGGCAACTAGCAAACAAGTTAGCCGAAGGAAGTACTGGGTTAATTT
CTGTTTTTCAAGGAAATTGGCTCACGGTTTCATTTAATTTAGCATTATTTTTAACCGCACTTTGTGCAGGAATTTTTATG
TTAATTATTTGGCGTATTTATCGAGAACCAGAGGCTTCATCATCAACTTGGAAAATTAAACGACCAAGATTTTTTACATT
GAATCTCAGTAAACCTTTGCTAAAAAATGAACGAATCAACGTTTTGCGATGTTCTTTCGGCATTATTCTTATGTGTTTTA
TGATTTTGTTGTTTAAACAATTTAGTAAGCCAACTTGGCAGGTAGATACTTTAGATGTGGGGCAGGGCTTGGCAACGCTG
ATTGTGAAAAATGGCAAAGGGATTCTTTATGATACGGGTTCTTCTTGGCGAGGTGGAAGTATGGCTGAGTTGGAAATTTT
GCCTTATTTACAAAGAGAAGGGATTGTTTTGGAAAAATTGATTTTAAGCCACGACGATAACGATCACGCAGGTGGTGCTT
CAACAATTTTAAAGGCGTATCCCAATGTGGAATTAATTACCCCTTCGCAAAAAAATTATGGGGAAAATTACCGCACTTTT
TGTACTGCTGGGCGTGATTGGCATTGGCAAGGGTTGCATTTTCAAATACTTTCTCCTCACAACGTTGTGACACGAGCTGA
TAATCCCCATTCTTGTGTAATTTTAGTCGATGATGGAAAGCATAGCGTTTTGCTAACTGGCGACGCTGAAGCAAAAAATG
AGCAAATTTTTGCCCGCACTTTAGGCAAAATCGATGTGTTGCAAGTGGGGCATCATGGGAGTAAAACATCGACAAGTGAA
TACTTGCTTTCTCAGGTTAGACCAGATGTAGCGATTATTTCTAGTGGGCGTTGGAATCCGTGGAAATTCCCTCATTATTC
GGTTATGGAAAGGCTTCATCGCTATAAAAGTGCGGTAGAAAATACCGCTGTTTCGGGGCAAGTGCGGGTAAATTTTTTTC
AAGACCGATTAGAAATCCAGCAAGCTCGCACAAAATTTTCCCCTTGGTATGCGCGTGTAATTGGATTATCAAAGGAATAA

Upstream 100 bases:

>100_bases
CGCTTGTTTTGATTTTTCTTTTTATTTTCTTGCGTAGAAATTTCTTAGTTAGCCTTGTCTTTTTTTTGTTGCCTCTCTTG
GCTATTTTCATTATTCGGCT

Downstream 100 bases:

>100_bases
AAGGTACAATGCACGCAATTTTTACTATTAGATAGCGATTATGCAAGAGCAAAAATTACAAGAAAATGATTTTTCAACCT
TACAAACTTTTAAACGTTTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MSLLQQAQNITAQKQVVTFKIQEILHQQDYQTLIATATLANNLQEQRIFLNWKAKEVPQLSEIWQAEISLRPLSARLNFG
GFDRQQWYFSKGITAVGTVKSAVKIADVSSLRAEKLQQVKKQTEGLSLQGLLIALAFGERAWLDKTTWSIYQQSNTAHLI
AISGLHIGLAMGIGFYLARVVQVFFPTRFIHPYFPLAFGVLFALIYAYLAGFSVPTFRAISALVFVLFIQIMRRHYSPLQ
LFTVVVGFLLFCNPLMPLSVSFWLSCEAVGCLILWYRYVPFSLFQWKNRPFSPKVRWILSLFHLQFGLLLFFTPLQLFLF
NGLSLSGFLANLMAVPIYSFLLVPLILFAVFTNGTMFFWQLANKLAEGSTGLISVFQGNWLTVSFNLALFLTALCAGIFM
LIIWRIYREPEASSSTWKIKRPRFFTLNLSKPLLKNERINVLRCSFGIILMCFMILLFKQFSKPTWQVDTLDVGQGLATL
IVKNGKGILYDTGSSWRGGSMAELEILPYLQREGIVLEKLILSHDDNDHAGGASTILKAYPNVELITPSQKNYGENYRTF
CTAGRDWHWQGLHFQILSPHNVVTRADNPHSCVILVDDGKHSVLLTGDAEAKNEQIFARTLGKIDVLQVGHHGSKTSTSE
YLLSQVRPDVAIISSGRWNPWKFPHYSVMERLHRYKSAVENTAVSGQVRVNFFQDRLEIQQARTKFSPWYARVIGLSKE

Sequences:

>Translated_719_residues
MSLLQQAQNITAQKQVVTFKIQEILHQQDYQTLIATATLANNLQEQRIFLNWKAKEVPQLSEIWQAEISLRPLSARLNFG
GFDRQQWYFSKGITAVGTVKSAVKIADVSSLRAEKLQQVKKQTEGLSLQGLLIALAFGERAWLDKTTWSIYQQSNTAHLI
AISGLHIGLAMGIGFYLARVVQVFFPTRFIHPYFPLAFGVLFALIYAYLAGFSVPTFRAISALVFVLFIQIMRRHYSPLQ
LFTVVVGFLLFCNPLMPLSVSFWLSCEAVGCLILWYRYVPFSLFQWKNRPFSPKVRWILSLFHLQFGLLLFFTPLQLFLF
NGLSLSGFLANLMAVPIYSFLLVPLILFAVFTNGTMFFWQLANKLAEGSTGLISVFQGNWLTVSFNLALFLTALCAGIFM
LIIWRIYREPEASSSTWKIKRPRFFTLNLSKPLLKNERINVLRCSFGIILMCFMILLFKQFSKPTWQVDTLDVGQGLATL
IVKNGKGILYDTGSSWRGGSMAELEILPYLQREGIVLEKLILSHDDNDHAGGASTILKAYPNVELITPSQKNYGENYRTF
CTAGRDWHWQGLHFQILSPHNVVTRADNPHSCVILVDDGKHSVLLTGDAEAKNEQIFARTLGKIDVLQVGHHGSKTSTSE
YLLSQVRPDVAIISSGRWNPWKFPHYSVMERLHRYKSAVENTAVSGQVRVNFFQDRLEIQQARTKFSPWYARVIGLSKE
>Mature_718_residues
SLLQQAQNITAQKQVVTFKIQEILHQQDYQTLIATATLANNLQEQRIFLNWKAKEVPQLSEIWQAEISLRPLSARLNFGG
FDRQQWYFSKGITAVGTVKSAVKIADVSSLRAEKLQQVKKQTEGLSLQGLLIALAFGERAWLDKTTWSIYQQSNTAHLIA
ISGLHIGLAMGIGFYLARVVQVFFPTRFIHPYFPLAFGVLFALIYAYLAGFSVPTFRAISALVFVLFIQIMRRHYSPLQL
FTVVVGFLLFCNPLMPLSVSFWLSCEAVGCLILWYRYVPFSLFQWKNRPFSPKVRWILSLFHLQFGLLLFFTPLQLFLFN
GLSLSGFLANLMAVPIYSFLLVPLILFAVFTNGTMFFWQLANKLAEGSTGLISVFQGNWLTVSFNLALFLTALCAGIFML
IIWRIYREPEASSSTWKIKRPRFFTLNLSKPLLKNERINVLRCSFGIILMCFMILLFKQFSKPTWQVDTLDVGQGLATLI
VKNGKGILYDTGSSWRGGSMAELEILPYLQREGIVLEKLILSHDDNDHAGGASTILKAYPNVELITPSQKNYGENYRTFC
TAGRDWHWQGLHFQILSPHNVVTRADNPHSCVILVDDGKHSVLLTGDAEAKNEQIFARTLGKIDVLQVGHHGSKTSTSEY
LLSQVRPDVAIISSGRWNPWKFPHYSVMERLHRYKSAVENTAVSGQVRVNFFQDRLEIQQARTKFSPWYARVIGLSKE

Specific function: Might contribute to transformation as a member of a membrane-bound pore complex at the base of the transformasome. It could directly interact with transforming DNA during translocation indirectly by participating in the assembly of the pore [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87081801, Length=700, Percent_Identity=33.4285714285714, Blast_Score=342, Evalue=4e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 81719; Mature: 81588

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLQQAQNITAQKQVVTFKIQEILHQQDYQTLIATATLANNLQEQRIFLNWKAKEVPQL
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCEEEEEECHHCCCHH
SEIWQAEISLRPLSARLNFGGFDRQQWYFSKGITAVGTVKSAVKIADVSSLRAEKLQQVK
HHHHHHHCEEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KQTEGLSLQGLLIALAFGERAWLDKTTWSIYQQSNTAHLIAISGLHIGLAMGIGFYLARV
HHHCCCCCHHEEEEEECCCCHHCCCHHHHHEECCCCEEEEEEECHHHHHHHHHHHHHHHH
VQVFFPTRFIHPYFPLAFGVLFALIYAYLAGFSVPTFRAISALVFVLFIQIMRRHYSPLQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
LFTVVVGFLLFCNPLMPLSVSFWLSCEAVGCLILWYRYVPFSLFQWKNRPFSPKVRWILS
HHHHHHHHHHHHCCCCCCCHHEEEEHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHH
LFHLQFGLLLFFTPLQLFLFNGLSLSGFLANLMAVPIYSFLLVPLILFAVFTNGTMFFWQ
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LANKLAEGSTGLISVFQGNWLTVSFNLALFLTALCAGIFMLIIWRIYREPEASSSTWKIK
HHHHHHCCCCCEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
RPRFFTLNLSKPLLKNERINVLRCSFGIILMCFMILLFKQFSKPTWQVDTLDVGQGLATL
CCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IVKNGKGILYDTGSSWRGGSMAELEILPYLQREGIVLEKLILSHDDNDHAGGASTILKAY
EEECCCEEEEECCCCCCCCCEEEEEEECHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHC
PNVELITPSQKNYGENYRTFCTAGRDWHWQGLHFQILSPHNVVTRADNPHSCVILVDDGK
CCCEEECCCCCCCCCCCCEEECCCCCEEECCEEEEEECCCCEEECCCCCCEEEEEEECCC
HSVLLTGDAEAKNEQIFARTLGKIDVLQVGHHGSKTSTSEYLLSQVRPDVAIISSGRWNP
CEEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCC
WKFPHYSVMERLHRYKSAVENTAVSGQVRVNFFQDRLEIQQARTKFSPWYARVIGLSKE
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHCCCCCC
>Mature Secondary Structure 
SLLQQAQNITAQKQVVTFKIQEILHQQDYQTLIATATLANNLQEQRIFLNWKAKEVPQL
CHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCEEEEEECHHCCCHH
SEIWQAEISLRPLSARLNFGGFDRQQWYFSKGITAVGTVKSAVKIADVSSLRAEKLQQVK
HHHHHHHCEEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KQTEGLSLQGLLIALAFGERAWLDKTTWSIYQQSNTAHLIAISGLHIGLAMGIGFYLARV
HHHCCCCCHHEEEEEECCCCHHCCCHHHHHEECCCCEEEEEEECHHHHHHHHHHHHHHHH
VQVFFPTRFIHPYFPLAFGVLFALIYAYLAGFSVPTFRAISALVFVLFIQIMRRHYSPLQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
LFTVVVGFLLFCNPLMPLSVSFWLSCEAVGCLILWYRYVPFSLFQWKNRPFSPKVRWILS
HHHHHHHHHHHHCCCCCCCHHEEEEHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHH
LFHLQFGLLLFFTPLQLFLFNGLSLSGFLANLMAVPIYSFLLVPLILFAVFTNGTMFFWQ
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LANKLAEGSTGLISVFQGNWLTVSFNLALFLTALCAGIFMLIIWRIYREPEASSSTWKIK
HHHHHHCCCCCEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
RPRFFTLNLSKPLLKNERINVLRCSFGIILMCFMILLFKQFSKPTWQVDTLDVGQGLATL
CCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IVKNGKGILYDTGSSWRGGSMAELEILPYLQREGIVLEKLILSHDDNDHAGGASTILKAY
EEECCCEEEEECCCCCCCCCEEEEEEECHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHC
PNVELITPSQKNYGENYRTFCTAGRDWHWQGLHFQILSPHNVVTRADNPHSCVILVDDGK
CCCEEECCCCCCCCCCCCEEECCCCCEEECCEEEEEECCCCEEECCCCCCEEEEEEECCC
HSVLLTGDAEAKNEQIFARTLGKIDVLQVGHHGSKTSTSEYLLSQVRPDVAIISSGRWNP
CEEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCC
WKFPHYSVMERLHRYKSAVENTAVSGQVRVNFFQDRLEIQQARTKFSPWYARVIGLSKE
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063112; 7542800 [H]