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The map label for this gene is trxA [H]

Identifier: 148825638

GI number: 148825638

Start: 578818

End: 579141

Strand: Direct

Name: trxA [H]

Synonym: CGSHiEE_02870

Alternate gene names: 148825638

Gene position: 578818-579141 (Clockwise)

Preceding gene: 148825637

Following gene: 148825646

Centisome position: 31.93

GC content: 36.73

Gene sequence:

>324_bases
ATGAGCGAAGTATTACACATTAATGACGCAGATTTTGAAAGCGTTGTAGTTAATTCAGATATCCCCGTTTTATTAGACTT
TTGGGCACCTTGGTGTGGTCCTTGCAAAATGATTGCTCCAGTGTTAGATGAACTTGCGCCTGAATTTTCTGGTAAAGTTA
AAATCGTGAAAATGAATGTGGATGACAACCAAGCAACGCCAGCACAATTTGGTGTTCGTAGTATCCCAACATTATTATTG
ATTAAAAATGGTCAAGTTGTTGCAACTCAAGTTGGTGCATTACCAAAAACTCAATTGGCTAACTTCATTAACCAACATAT
TTAA

Upstream 100 bases:

>100_bases
TTAGTTTACATTTTTTAAAACGGTGTTATTCTGCATCGCACTTGTAAGTTTAAAAAAAGCCCTTATATAGGGATTCCATT
CACAAAATAAGGAAAACAAA

Downstream 100 bases:

>100_bases
TCGTTGTTTAAAGCTATAAGTAACTTTAGCGCATTGATAAGATTGCCCCTTAATGGGGCAATTTTTTTGTCTGAAATTTT
GATATTTGCTCTGGTGGAAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSEVLHINDADFESVVVNSDIPVLLDFWAPWCGPCKMIAPVLDELAPEFSGKVKIVKMNVDDNQATPAQFGVRSIPTLLL
IKNGQVVATQVGALPKTQLANFINQHI

Sequences:

>Translated_107_residues
MSEVLHINDADFESVVVNSDIPVLLDFWAPWCGPCKMIAPVLDELAPEFSGKVKIVKMNVDDNQATPAQFGVRSIPTLLL
IKNGQVVATQVGALPKTQLANFINQHI
>Mature_106_residues
SEVLHINDADFESVVVNSDIPVLLDFWAPWCGPCKMIAPVLDELAPEFSGKVKIVKMNVDDNQATPAQFGVRSIPTLLLI
KNGQVVATQVGALPKTQLANFINQHI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=105, Percent_Identity=40, Blast_Score=86, Evalue=7e-18,
Organism=Homo sapiens, GI21361657, Length=108, Percent_Identity=32.4074074074074, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI4758304, Length=87, Percent_Identity=36.7816091954023, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=51.4285714285714, Blast_Score=132, Evalue=6e-33,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=45.6521739130435, Blast_Score=104, Evalue=1e-24,
Organism=Escherichia coli, GI87081747, Length=85, Percent_Identity=36.4705882352941, Blast_Score=70, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=37.2340425531915, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=40.2298850574713, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=78, Percent_Identity=38.4615384615385, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=106, Percent_Identity=32.0754716981132, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=99, Percent_Identity=32.3232323232323, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=112, Percent_Identity=31.25, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=31.3953488372093, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=103, Percent_Identity=32.0388349514563, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=79, Percent_Identity=37.9746835443038, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=87, Percent_Identity=34.4827586206897, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17507915, Length=84, Percent_Identity=36.9047619047619, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=85, Percent_Identity=38.8235294117647, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=90, Percent_Identity=36.6666666666667, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=38.3720930232558, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=39.5348837209302, Blast_Score=70, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=88, Percent_Identity=35.2272727272727, Blast_Score=63, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=41.4893617021277, Blast_Score=88, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=37.1134020618557, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=43.6619718309859, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=41.1764705882353, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=41.1764705882353, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17530795, Length=93, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921434, Length=87, Percent_Identity=35.632183908046, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551086, Length=70, Percent_Identity=41.4285714285714, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358065, Length=91, Percent_Identity=34.0659340659341, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639068, Length=94, Percent_Identity=32.9787234042553, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11683; Mature: 11552

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVLHINDADFESVVVNSDIPVLLDFWAPWCGPCKMIAPVLDELAPEFSGKVKIVKMNV
CCCEEECCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEC
DDNQATPAQFGVRSIPTLLLIKNGQVVATQVGALPKTQLANFINQHI
CCCCCCHHHCCHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SEVLHINDADFESVVVNSDIPVLLDFWAPWCGPCKMIAPVLDELAPEFSGKVKIVKMNV
CCEEECCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEC
DDNQATPAQFGVRSIPTLLLIKNGQVVATQVGALPKTQLANFINQHI
CCCCCCHHHCCHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]