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The map label for this gene is ffh [H]

Identifier: 148825617

GI number: 148825617

Start: 547028

End: 548407

Strand: Direct

Name: ffh [H]

Synonym: CGSHiEE_02745

Alternate gene names: 148825617

Gene position: 547028-548407 (Clockwise)

Preceding gene: 148825614

Following gene: 148825623

Centisome position: 30.17

GC content: 43.04

Gene sequence:

>1380_bases
ATGTTTGAGAATTTATCGGATCGCCTTTCCAAAACCTTACGTAATATCACAGGAAAAGGTCGTTTAACGGAAGATAATAT
TAAAGAAACCTTACGCGAAGTGCGTATGGCATTACTTGAAGCCGATGTTGCCTTGCCAGTGGTGCGTGAATTTATTGCAA
AAGTAAAAGAAAGCGCGCTTGGGGAAGAAGTCAATAAAAGTTTAACGCCAGGACAAGAATTCTTAAAAATCGTTCAGCGT
GAGCTTGAAAAAGCCATGGGCGAAGCCAATGAAAGTTTAAATCTCGCAACCCAACCACCAGCAGTTATCTTAATGGCAGG
TTTACAAGGGGCGGGTAAAACCACCAGCGTGGGTAAATTGGCAAAATTTTTGCGTGAACGCCATAAAAAGAAAGTATTAG
TGGTGTCTGCTGACGTATATCGCCCTGCTGCGATTAAGCAACTTGAAACCTTGGCTCAATCCGTTGGCGTGGATTTTTTT
CCATCGGATGTTAAACAAAACCCCGTTGATATTGCTAAAGCGGCACTTGCTGATGCAAAACTGAAATTCTACGATGTGTT
GATTGTGGATACGGCAGGTCGCCTACACGTTGATACAGAAATGATGGACGAAATCAAGCAAGTCCATGCAGCGTTAAATC
CAATCGAAACCCTTTTCACTGTTGATGCGATGACTGGCCAAGATGCGGCCAATACGGCAAAAGCCTTTAATGAAGCATTA
CCGCTTACGGGTGTTATTTTGACGAAAGTGGACGGTGATGCACGCGGTGGTGCGGCGTTATCTATTCGTCAAATCACAGG
TAAACCAATCAAATTCTTGGGTGTGGGCGAGAAAACAGAAGCGCTTGAGCCGTTCCATCCTGATCGTGTCGCTTCCCGTA
TTTTGGGCATGGGCGATGTGCTTTCCCTTATCGAAGATCTTGAACGTTCTGTTGATCGTGAAAAAGCGGAAAAAATGGCG
CAGAAATTCAAGAAAGGCGATGATTTTACTTTAGATGATTTCCGCGAACAGCTGATCGAAATGAAAAAAATGGGTGGCAT
GATGTCTATGCTTGAGAAATTACCAGGTGCAAAAAATTTGCCTGATCACGTTAAAAATCAAGTAGATGACAAAATGTTTA
TCAAAATGGAAGCGATCATTAACTCCATGACCCTAAAAGAACGTGCCAACCCAGATATTATCAAAGGATCTCGCCGTCGT
CGTATTGCATTAGGCTCTGGCACTCAGGTACAAGATGTCAATAAATTACTTAAACAATTCGATGAAATGCAACGTATGAT
GAAGAAAATGCGTAAAGGTGGCATGGCTAAAATGATGCGTGGAATGCAAGGCTTAATGGGCGGAGGCTTAGGCGGTCTTG
GCGGAATGTTTAAACGATAA

Upstream 100 bases:

>100_bases
AATCGCCTACTCAAAAATCCATTTTCATTTGAAATGATGAAAAACGCCTAAATTTCGGTATAATCAGCGTAATTTTTTAA
GAAAAACAGGATTGTTAGCC

Downstream 100 bases:

>100_bases
TTTCAGAAGATAAAAGTGCGGTTAAAAAAGAAATATTTTTACCGCACTTTTGTGTTTTATGAATTATAGCTAATTTATAA
ATTATTCTAATTAACGACGT

Product: Signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQR
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKAALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLPDHVKNQVDDKMFIKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGMFKR

Sequences:

>Translated_459_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQR
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKAALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLPDHVKNQVDDKMFIKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGMFKR
>Mature_459_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQR
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKAALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLPDHVKNQVDDKMFIKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGMFKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=444, Percent_Identity=32.4324324324324, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI226371618, Length=346, Percent_Identity=34.6820809248555, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=35.7575757575758, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI23308697, Length=222, Percent_Identity=29.2792792792793, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI295424842, Length=222, Percent_Identity=29.2792792792793, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=80.3097345132743, Blast_Score=714, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=36.2204724409449, Blast_Score=158, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=30.0448430493274, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193206261, Length=216, Percent_Identity=32.4074074074074, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=438, Percent_Identity=32.4200913242009, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=314, Percent_Identity=26.1146496815287, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17647949, Length=433, Percent_Identity=29.3302540415704, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=28.1818181818182, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50611; Mature: 50611

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVNKSLTPGQEFLKIVQRELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFFPSDVKQNPVDIAKAALADAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCH
LKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
HEEEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDLERSVDREKAEKMAQKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
PDHVKNQVDDKMFIKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQF
CHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGMFKR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCCCCCC
>Mature Secondary Structure
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVNKSLTPGQEFLKIVQRELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFFPSDVKQNPVDIAKAALADAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCH
LKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
HEEEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDLERSVDREKAEKMAQKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
PDHVKNQVDDKMFIKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQF
CHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGMFKR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]