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The map label for this gene is gor [H]

Identifier: 148825570

GI number: 148825570

Start: 487635

End: 489005

Strand: Direct

Name: gor [H]

Synonym: CGSHiEE_02475

Alternate gene names: 148825570

Gene position: 487635-489005 (Clockwise)

Preceding gene: 148825569

Following gene: 148825572

Centisome position: 26.9

GC content: 38.44

Gene sequence:

>1371_bases
ATGACTAAACATTATGATTATATTGCTATTGGCGGTGGCAGTGGCGGTATTGCGTCTCTAAATCGAGCAGCAAGTTATGG
AAAAAAATGTGCAATCATTGAAGCAAAACATCTTGGCGGAACTTGTGTAAATGTCGGTTGCGTACCCAAAAAAGTGATGT
TTTATGGCGCGCATATTGCAGAAGCAATCAACAATTATGCGCCAGATTATGGTTTTGATGTTGAAGTGAAAAAATTTGAT
TTTTCAAAACTGATTGAAAGTCGCCAAGCCTATATTAGTCGTATCCATACATCTTATAATAATGTATTAGCGAAAAATAA
TATTGATGTAATTAATGGTTTCGGAAAATTTGTCGATGCCCATACTATTGAAGTAACACTTGCTGATGGTACAAAAGAGC
AAGTAACCGCAGATCATATTTTAATCGCAACTGGTGGTCGTCCATATCGTCCAAATATTAAAGGACAAGAATACGGCATT
GATTCAGATGGTTTCTTTGCATTAACCGAATTACCAAAACGTGCTGTTGTTATTGGTGCAGGCTATATTGCTGTTGAACT
TTCTGGCGTATTAAACAGCTTAGGCGTGGAAACACATTTATTAGTGCGTCGCCATGCGCCAATGCGTAATCAGGATCCAT
TAATCGTAGAAACATTAGTGGAAGTGCTTGCGCAAGATGGAATTCAATTACATACCAATTCTACCCCATCTGAAATTGTA
AAAAATGCAGATGGTTCACTTACTGTAAGATGTGATGGTCAATCTGATGTTACCGTAGATTGCGTTATTTGGGCGGCAGG
TCGTGTTCCAACGACAGATAAAATTGGCTTAGAAAATGCAGGTGTAGAAACAAATGAACACGGCTATGTCAAAGTAGATA
AATATCAAAATACTAATGTGAAAGGCATTTATGCGGTAGGCGATATTATCGAAAACGGTATTGAATTAACACCAGTTGCA
GTTGCAGCAGGTCGCCGCCTTTCAGAGCGTTTATTTAATAATAAACCGACTGAATATTTAGATTACAGTTTAGTTCCAAC
CGTTGTATTTAGCCATCCGCCTATCGGCACTGTAGGTTTAACTGAACCGCAAGCGATTGAGCAGTACGGCGCAGAAAATG
TTAAGGTATATAAATCTTCTTTCACAGCGATGTACACTGCGGTAACTCAACATCGCCAACCGTGCAAAATGAAATTAGTT
TGTGTGGGTAAAGATGAAAAAGTTGTGGGTTTACATGGTATTGGTTTCGGTGTAGATGAAATGATTCAAGGATTTGCAGT
AGCAATCAAAATGGGTGCAACAAAAGCTGATTTTGACAATACAGTGGCAATTCATCCAACAGGTTCAGAGGAATTTGTAA
CAATGCGTTAA

Upstream 100 bases:

>100_bases
ATAAAAAATATTCATAAAACCAATTACATCAATTTATAGCATTCTTTATAAAAATTAGGCAAAATACGGAAAATTTTTGA
GTTCAAAAAAGGATCAAACT

Downstream 100 bases:

>100_bases
TTGTTCAAATGAAAGAAGAAAAAGGCAGTAAGGTTATACTGCCTTTAAAGAAGTGAGAAATATCTATTTTCAGGATTTGT
TTCTGTCATTTATGGAAATA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINNYAPDYGFDVEVKKFD
FSKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDAHTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGI
DSDGFFALTELPKRAVVIGAGYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIV
KNADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNVKGIYAVGDIIENGIELTPVA
VAAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLV
CVGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Sequences:

>Translated_456_residues
MTKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINNYAPDYGFDVEVKKFD
FSKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDAHTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGI
DSDGFFALTELPKRAVVIGAGYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIV
KNADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNVKGIYAVGDIIENGIELTPVA
VAAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLV
CVGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
>Mature_455_residues
TKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINNYAPDYGFDVEVKKFDF
SKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDAHTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGID
SDGFFALTELPKRAVVIGAGYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIVK
NADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNVKGIYAVGDIIENGIELTPVAV
AAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLVC
VGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=52.258064516129, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=39.1578947368421, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=37.1428571428571, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI291045266, Length=455, Percent_Identity=35.1648351648352, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI291045268, Length=455, Percent_Identity=31.8681318681319, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=29.6296296296296, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1789915, Length=457, Percent_Identity=73.3041575492341, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=448, Percent_Identity=28.5714285714286, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=26.6958424507659, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=26.6519823788546, Blast_Score=145, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=456, Percent_Identity=51.7543859649123, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71983429, Length=456, Percent_Identity=51.5350877192982, Blast_Score=413, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=36.1522198731501, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=33.2640332640333, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=30.58568329718, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=49.5708154506438, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321091, Length=469, Percent_Identity=28.1449893390192, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=23.6673773987207, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=38.936170212766, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=38.936170212766, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=38.936170212766, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=37.6321353065539, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=30.5555555555556, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49358; Mature: 49227

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIA
CCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAINNYAPDYGFDVEVKKFDFSKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDA
HHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEECCHHHCCC
HTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGIDSDGFFALTELPKRAVVIGA
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEC
GYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIV
CEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHH
KNADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNV
HCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCC
KGIYAVGDIIENGIELTPVAVAAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGL
CEEEEEHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCHHHCCCEEECEEEECCCCCCCCCC
TEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLVCVGKDEKVVGLHGIGFGVDE
CCCHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHH
MIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
HHHHEEEEEEECCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure 
TKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIA
CCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAINNYAPDYGFDVEVKKFDFSKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDA
HHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEECCHHHCCC
HTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGIDSDGFFALTELPKRAVVIGA
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEC
GYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIV
CEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHH
KNADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNV
HCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCC
KGIYAVGDIIENGIELTPVAVAAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGL
CEEEEEHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCHHHCCCEEECEEEECCCCCCCCCC
TEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLVCVGKDEKVVGLHGIGFGVDE
CCCHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHH
MIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
HHHHEEEEEEECCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]