| Definition | Haemophilus influenzae PittEE chromosome, complete genome. |
|---|---|
| Accession | NC_009566 |
| Length | 1,813,033 |
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The map label for this gene is menD [H]
Identifier: 148825438
GI number: 148825438
Start: 305919
End: 307625
Strand: Direct
Name: menD [H]
Synonym: CGSHiEE_01640
Alternate gene names: 148825438
Gene position: 305919-307625 (Clockwise)
Preceding gene: 148825437
Following gene: 148825439
Centisome position: 16.87
GC content: 41.48
Gene sequence:
>1707_bases ATGTCGGTAAGCGTGTTTAATCGTTGTTGGTCGAAAGTGATTTTAGAAACCTTGGTGCGTCAAGGCGTTTCTCACGTTTG TATCGCGCCAGGTTCGCGTTCGACACCTTTAACTCTAGAAGCCGTACGTTTGCAAAATGCGGGTTCAGTCACTTGTTATA CGCATTTTGATGAACGCGGTTTAGGTTTTTTTGCTTTGGGTATTGCTAAGGCAACTCAATCCCCTGTCGCAATTATTGTG ACATCAGGCACAGCAACAGCAAACCTTTATCCTGCCATTATTGAAGCACGCCAAACGGGTGTGAATTTATTTGTTTTAAC TGCTGATCGTCCACCAGAACTTTGGGAGTGCGGTGCAAATCAGGCTATTTTGCAACAAAATATGTTTGGTCAGTATCCGG TTGCAAATGTTAATTTACCTAAACCGAAAGCTGATTATTCTGCGCAGTGGTTAATTTCTCTACTTGAACAGGCTGCCTTC CAACAAAAACAACAAGGTGGCGTTGTTCATATTAATGTACCATTTTCCGAGCCACTTTATGATGCAACTGATGAGGCTGT AGATTCCCATAGTTGGCTGCAGCCATTACAACGCTGGTTAATTCAAACTAAGCCTTGGATGAATGTGGAAGCTCAACAGA ACGAAGTATTAATGCATGAAAACTGGGATCATTGGCGTACCAAACGTGGTGTCGTTGTGGTTGGTCAATTGCCTGCAGAA CAAGCGATGGGCATTAACTCTTGGGCAAGTGCTATGGGCTGGGTGTTACTGACGGATATTCAATCTGGTGTTGTTCCAAC GACACCTTATGAAGATATTTGGCTGGCAAACCAAACTGTTCGTGAAAAACTTCTGCAAGCTGATATTGTGATTCAATTTG GCGCACGTTTTATTAGTAAACGCATTAATCAATTCTTACAGGCGTTTAAAGGGGAATTTTGGTTGGTTGAACAAAGCGGT AAGGCATTAGATCCTTATCATCATTCGCTGACAAGATTTAATGCTAAAGCACATCATTGGTTGCGTGCGCATCCTCCTTT ACGCCAAAAGCCTTGGTTGCTTGAGCCATTAGCTTTATCTAAGTTCTGTGCGACCTTTATTGAACAGCAAGTAGGCGGAA ATTTAACGGAAGCCTCGTTCGCATTACGTTTACCAACACTTTTACCTTATAACGGTGTTTTATTTTTAGGTAATAGTTTA CTTGTTCGTCTTGTTGATGCGCTAACGCAATTACCAGAAAGTTATCCTGTTTATACCAATCGTGGTGCGAGTGGAATTGA TGGTTTGTTGGCTACGGCAGCTGGAATTGGTATAGGTTCAAATAAACCTGTTGTTGCGGTGATTGGCGATACGTCCACTT TATATGATCTAAATTCTTTCGCATTATTCAAAAACGTTACGCAACCAACAGTAATCTTTGTGATCAATAATAATGGTGGC GCGATTTTTGATATGTTACCTGTGGATGAACAAGTCAAAGATCAGTTCTATCGATTACCGCATAATGGCGATTTTTCTCA AATTGCGGCAATGTTCGATCTCAAATACGCTCATCCTTATACTTGGGCGGATCTCAATTCCGTTGTTAAACAGGCTTATA GTCGTCGCAAGGCAACGTTAATTGAAATTAAAACGAATCCGAGTGATGGTAGTAGTTTGTATAAACGCTTAATCGAGCAA ATTAGTCACGCCGTGATTGGTGCTTAA
Upstream 100 bases:
>100_bases TGGCAGGCTCGCAGCCATTGGAAGAGTGGAAAGAAATTGAACGTAAAGCAGCAGGGTTGATTTCCTTGTTTGCAGAAGAA AAATGATAACGGAGAAAAAA
Downstream 100 bases:
>100_bases GTATTCTGTAGGCGGGCTTTAGTCCGCCATATTTTATTATTTCTATCAATAATCCCTTCAATGATAAACATCATTTTTCT TCACGGACTTCTTGGTACAA
Product: 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase
Products: NA
Alternate protein names: SEPHCHC synthase; Menaquinone biosynthesis protein menD [H]
Number of amino acids: Translated: 568; Mature: 567
Protein sequence:
>568_residues MSVSVFNRCWSKVILETLVRQGVSHVCIAPGSRSTPLTLEAVRLQNAGSVTCYTHFDERGLGFFALGIAKATQSPVAIIV TSGTATANLYPAIIEARQTGVNLFVLTADRPPELWECGANQAILQQNMFGQYPVANVNLPKPKADYSAQWLISLLEQAAF QQKQQGGVVHINVPFSEPLYDATDEAVDSHSWLQPLQRWLIQTKPWMNVEAQQNEVLMHENWDHWRTKRGVVVVGQLPAE QAMGINSWASAMGWVLLTDIQSGVVPTTPYEDIWLANQTVREKLLQADIVIQFGARFISKRINQFLQAFKGEFWLVEQSG KALDPYHHSLTRFNAKAHHWLRAHPPLRQKPWLLEPLALSKFCATFIEQQVGGNLTEASFALRLPTLLPYNGVLFLGNSL LVRLVDALTQLPESYPVYTNRGASGIDGLLATAAGIGIGSNKPVVAVIGDTSTLYDLNSFALFKNVTQPTVIFVINNNGG AIFDMLPVDEQVKDQFYRLPHNGDFSQIAAMFDLKYAHPYTWADLNSVVKQAYSRRKATLIEIKTNPSDGSSLYKRLIEQ ISHAVIGA
Sequences:
>Translated_568_residues MSVSVFNRCWSKVILETLVRQGVSHVCIAPGSRSTPLTLEAVRLQNAGSVTCYTHFDERGLGFFALGIAKATQSPVAIIV TSGTATANLYPAIIEARQTGVNLFVLTADRPPELWECGANQAILQQNMFGQYPVANVNLPKPKADYSAQWLISLLEQAAF QQKQQGGVVHINVPFSEPLYDATDEAVDSHSWLQPLQRWLIQTKPWMNVEAQQNEVLMHENWDHWRTKRGVVVVGQLPAE QAMGINSWASAMGWVLLTDIQSGVVPTTPYEDIWLANQTVREKLLQADIVIQFGARFISKRINQFLQAFKGEFWLVEQSG KALDPYHHSLTRFNAKAHHWLRAHPPLRQKPWLLEPLALSKFCATFIEQQVGGNLTEASFALRLPTLLPYNGVLFLGNSL LVRLVDALTQLPESYPVYTNRGASGIDGLLATAAGIGIGSNKPVVAVIGDTSTLYDLNSFALFKNVTQPTVIFVINNNGG AIFDMLPVDEQVKDQFYRLPHNGDFSQIAAMFDLKYAHPYTWADLNSVVKQAYSRRKATLIEIKTNPSDGSSLYKRLIEQ ISHAVIGA >Mature_567_residues SVSVFNRCWSKVILETLVRQGVSHVCIAPGSRSTPLTLEAVRLQNAGSVTCYTHFDERGLGFFALGIAKATQSPVAIIVT SGTATANLYPAIIEARQTGVNLFVLTADRPPELWECGANQAILQQNMFGQYPVANVNLPKPKADYSAQWLISLLEQAAFQ QKQQGGVVHINVPFSEPLYDATDEAVDSHSWLQPLQRWLIQTKPWMNVEAQQNEVLMHENWDHWRTKRGVVVVGQLPAEQ AMGINSWASAMGWVLLTDIQSGVVPTTPYEDIWLANQTVREKLLQADIVIQFGARFISKRINQFLQAFKGEFWLVEQSGK ALDPYHHSLTRFNAKAHHWLRAHPPLRQKPWLLEPLALSKFCATFIEQQVGGNLTEASFALRLPTLLPYNGVLFLGNSLL VRLVDALTQLPESYPVYTNRGASGIDGLLATAAGIGIGSNKPVVAVIGDTSTLYDLNSFALFKNVTQPTVIFVINNNGGA IFDMLPVDEQVKDQFYRLPHNGDFSQIAAMFDLKYAHPYTWADLNSVVKQAYSRRKATLIEIKTNPSDGSSLYKRLIEQI SHAVIGA
Specific function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-ca
COG id: COG1165
COG function: function code H; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family. MenD subfamily [H]
Homologues:
Organism=Escherichia coli, GI1788599, Length=566, Percent_Identity=47.5265017667844, Blast_Score=515, Evalue=1e-147,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004433 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.9 [H]
Molecular weight: Translated: 63078; Mature: 62947
Theoretical pI: Translated: 7.43; Mature: 7.43
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSVSVFNRCWSKVILETLVRQGVSHVCIAPGSRSTPLTLEAVRLQNAGSVTCYTHFDERG CCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEEEECCCCC LGFFALGIAKATQSPVAIIVTSGTATANLYPAIIEARQTGVNLFVLTADRPPELWECGAN CCEEEEEHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCC QAILQQNMFGQYPVANVNLPKPKADYSAQWLISLLEQAAFQQKQQGGVVHINVPFSEPLY HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC DATDEAVDSHSWLQPLQRWLIQTKPWMNVEAQQNEVLMHENWDHWRTKRGVVVVGQLPAE CCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHCCCCEEEEECCCHH QAMGINSWASAMGWVLLTDIQSGVVPTTPYEDIWLANQTVREKLLQADIVIQFGARFISK HHCCCHHHHHHHCCEEEEEHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH RINQFLQAFKGEFWLVEQSGKALDPYHHSLTRFNAKAHHWLRAHPPLRQKPWLLEPLALS HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHEECCCCCCCCCCCCCHHHHH KFCATFIEQQVGGNLTEASFALRLPTLLPYNGVLFLGNSLLVRLVDALTQLPESYPVYTN HHHHHHHHHHHCCCCCCCHHEEECCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCEEC RGASGIDGLLATAAGIGIGSNKPVVAVIGDTSTLYDLNSFALFKNVTQPTVIFVINNNGG CCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECHHHHHHHCCCCCEEEEEEECCCC AIFDMLPVDEQVKDQFYRLPHNGDFSQIAAMFDLKYAHPYTWADLNSVVKQAYSRRKATL EEEEECCCCHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEE IEIKTNPSDGSSLYKRLIEQISHAVIGA EEEECCCCCHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure SVSVFNRCWSKVILETLVRQGVSHVCIAPGSRSTPLTLEAVRLQNAGSVTCYTHFDERG CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEEEECCCCC LGFFALGIAKATQSPVAIIVTSGTATANLYPAIIEARQTGVNLFVLTADRPPELWECGAN CCEEEEEHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCC QAILQQNMFGQYPVANVNLPKPKADYSAQWLISLLEQAAFQQKQQGGVVHINVPFSEPLY HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC DATDEAVDSHSWLQPLQRWLIQTKPWMNVEAQQNEVLMHENWDHWRTKRGVVVVGQLPAE CCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHCCCCEEEEECCCHH QAMGINSWASAMGWVLLTDIQSGVVPTTPYEDIWLANQTVREKLLQADIVIQFGARFISK HHCCCHHHHHHHCCEEEEEHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH RINQFLQAFKGEFWLVEQSGKALDPYHHSLTRFNAKAHHWLRAHPPLRQKPWLLEPLALS HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHEECCCCCCCCCCCCCHHHHH KFCATFIEQQVGGNLTEASFALRLPTLLPYNGVLFLGNSLLVRLVDALTQLPESYPVYTN HHHHHHHHHHHCCCCCCCHHEEECCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCEEC RGASGIDGLLATAAGIGIGSNKPVVAVIGDTSTLYDLNSFALFKNVTQPTVIFVINNNGG CCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECHHHHHHHCCCCCEEEEEEECCCC AIFDMLPVDEQVKDQFYRLPHNGDFSQIAAMFDLKYAHPYTWADLNSVVKQAYSRRKATL EEEEECCCCHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEE IEIKTNPSDGSSLYKRLIEQISHAVIGA EEEECCCCCHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA