Click here to switch to the map view.

The map label for this gene is pdxY

Identifier: 148825314

GI number: 148825314

Start: 186285

End: 187151

Strand: Direct

Name: pdxY

Synonym: CGSHiEE_00970

Alternate gene names: 148825314

Gene position: 186285-187151 (Clockwise)

Preceding gene: 148825313

Following gene: 148825315

Centisome position: 10.27

GC content: 39.91

Gene sequence:

>867_bases
ATGAAAAACGTACTTTCAATCCAATCCCATGTGGTCTATGGTTTTGCAGGTAACAAATCTGCGACTTTTCCAATGCAGTT
GTTAGGCGTAGATGTATGGGCATTAAATACTGTTCAATTTTCTAATCACACGCAATACGGAAAATGGACAGGCATGGTCA
TTCCTCAAGAACAAATCCGAGAAATTGTAACTGGACTCGATAACATTGAAAAACTACAAGAATGTGATGCTTTATTATCT
GGTTACTTAGGTTCTGCGGAACAAGTCGATCAAATTCTTTTTGCTTTAGAGCAAATCAAACTGCGTAACCCAAATGCGCT
TTATTTATGCGACCCTGTAATGCCACATCCGAAAAAAAGCTGCGTGGTTGCCAATGGTGTTTGCGAGGCTCTTATTGAAA
AAGCGATTCCAGTGGCAGACATTATGACGCCAAACCTGCATGAATTACGTCAGCTCACTGAATTCCCAATTAATACCTTT
GATGATGTGTTAAAAGCAGTGAATGCGCTGATTGCAAAAGGCGTGAAGAAAGTTCTCGTTAAACATTTAGGCAGTGCGGG
TAAAATTAACGATCCTGATACATTTGAAATTATTATGGCAACCCCAGAGGGTGTTTGGCATTTAAGCCGTCCACTTTATC
AATTCAATTTTGAACCAGTGGGCGTGGGCGATTTAATCGCAGGGACATTCTTAGCAAATTTACTCAATGGAAAATCTGAC
GTAGAAGCCTTTGAAGCCATGAATAACGAAGTGGCAGGCGTAATGAAAACCACCTTTGAACTGGGTTCTTACGAGTTACA
AACCATTGCTGCACGTTTTGAAATTCTTAATCCAAGCAGTAACTATAAAGCTGAAAAAGTTGCCTAA

Upstream 100 bases:

>100_bases
ACGTTTAATGTCTTACGGTTATTGCTAACTAACATTCTAAAAGAGCGGTGATTTTTGCCGCTCTTTTTTGATCTAAATAT
ACAACAAAGGAGAAAACACA

Downstream 100 bases:

>100_bases
TGGATTTACTTTCAGACATTGAAAAACAACTCCAAAAAGCCACCGCTCAAGGGTTTCTTATCGCCTTGAGTGGTGGTTTA
GATTCCACTGTACTTCTTTC

Product: pyridoxamine kinase

Products: NA

Alternate protein names: PM kinase

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MKNVLSIQSHVVYGFAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPQEQIREIVTGLDNIEKLQECDALLS
GYLGSAEQVDQILFALEQIKLRNPNALYLCDPVMPHPKKSCVVANGVCEALIEKAIPVADIMTPNLHELRQLTEFPINTF
DDVLKAVNALIAKGVKKVLVKHLGSAGKINDPDTFEIIMATPEGVWHLSRPLYQFNFEPVGVGDLIAGTFLANLLNGKSD
VEAFEAMNNEVAGVMKTTFELGSYELQTIAARFEILNPSSNYKAEKVA

Sequences:

>Translated_288_residues
MKNVLSIQSHVVYGFAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPQEQIREIVTGLDNIEKLQECDALLS
GYLGSAEQVDQILFALEQIKLRNPNALYLCDPVMPHPKKSCVVANGVCEALIEKAIPVADIMTPNLHELRQLTEFPINTF
DDVLKAVNALIAKGVKKVLVKHLGSAGKINDPDTFEIIMATPEGVWHLSRPLYQFNFEPVGVGDLIAGTFLANLLNGKSD
VEAFEAMNNEVAGVMKTTFELGSYELQTIAARFEILNPSSNYKAEKVA
>Mature_288_residues
MKNVLSIQSHVVYGFAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPQEQIREIVTGLDNIEKLQECDALLS
GYLGSAEQVDQILFALEQIKLRNPNALYLCDPVMPHPKKSCVVANGVCEALIEKAIPVADIMTPNLHELRQLTEFPINTF
DDVLKAVNALIAKGVKKVLVKHLGSAGKINDPDTFEIIMATPEGVWHLSRPLYQFNFEPVGVGDLIAGTFLANLLNGKSD
VEAFEAMNNEVAGVMKTTFELGSYELQTIAARFEILNPSSNYKAEKVA

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family

Homologues:

Organism=Homo sapiens, GI4505701, Length=243, Percent_Identity=31.6872427983539, Blast_Score=128, Evalue=5e-30,
Organism=Escherichia coli, GI1787924, Length=288, Percent_Identity=51.0416666666667, Blast_Score=295, Evalue=2e-81,
Organism=Escherichia coli, GI1788758, Length=264, Percent_Identity=28.030303030303, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17507759, Length=295, Percent_Identity=32.5423728813559, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17507757, Length=301, Percent_Identity=31.5614617940199, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320806, Length=271, Percent_Identity=33.5793357933579, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324354, Length=245, Percent_Identity=32.2448979591837, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45553007, Length=300, Percent_Identity=33, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXY_HAEIE (A5UA83)

Other databases:

- EMBL:   CP000671
- RefSeq:   YP_001290067.1
- ProteinModelPortal:   A5UA83
- SMR:   A5UA83
- STRING:   A5UA83
- GeneID:   5225308
- GenomeReviews:   CP000671_GR
- KEGG:   hip:CGSHiEE_00970
- eggNOG:   COG2240
- HOGENOM:   HBG661459
- OMA:   CPNQLEL
- ProtClustDB:   PRK05756
- BioCyc:   HINF374930:CGSHIEE_00970-MONOMER
- HAMAP:   MF_01639
- InterPro:   IPR013749
- InterPro:   IPR004625
- TIGRFAMs:   TIGR00687

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.35

Molecular weight: Translated: 31693; Mature: 31693

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: BINDING 9-9 BINDING 44-44 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVLSIQSHVVYGFAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPQEQIR
CCCHHEEHHEEEEEEECCCCCCCHHHHHHCHHHEEEEEEECCCCCCCCEEEEECCHHHHH
EIVTGLDNIEKLQECDALLSGYLGSAEQVDQILFALEQIKLRNPNALYLCDPVMPHPKKS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
CVVANGVCEALIEKAIPVADIMTPNLHELRQLTEFPINTFDDVLKAVNALIAKGVKKVLV
EEEHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
KHLGSAGKINDPDTFEIIMATPEGVWHLSRPLYQFNFEPVGVGDLIAGTFLANLLNGKSD
HHCCCCCCCCCCCCEEEEEECCCCCHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCHHH
VEAFEAMNNEVAGVMKTTFELGSYELQTIAARFEILNPSSNYKAEKVA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure
MKNVLSIQSHVVYGFAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPQEQIR
CCCHHEEHHEEEEEEECCCCCCCHHHHHHCHHHEEEEEEECCCCCCCCEEEEECCHHHHH
EIVTGLDNIEKLQECDALLSGYLGSAEQVDQILFALEQIKLRNPNALYLCDPVMPHPKKS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
CVVANGVCEALIEKAIPVADIMTPNLHELRQLTEFPINTFDDVLKAVNALIAKGVKKVLV
EEEHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
KHLGSAGKINDPDTFEIIMATPEGVWHLSRPLYQFNFEPVGVGDLIAGTFLANLLNGKSD
HHCCCCCCCCCCCCEEEEEECCCCCHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCHHH
VEAFEAMNNEVAGVMKTTFELGSYELQTIAARFEILNPSSNYKAEKVA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA