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The map label for this gene is tyrP-B [H]

Identifier: 148825198

GI number: 148825198

Start: 65201

End: 66421

Strand: Direct

Name: tyrP-B [H]

Synonym: CGSHiEE_00350

Alternate gene names: 148825198

Gene position: 65201-66421 (Clockwise)

Preceding gene: 148825197

Following gene: 148825200

Centisome position: 3.6

GC content: 40.79

Gene sequence:

>1221_bases
ATGCTAAAAAACAAAACTTTTGGGAGTGCGCTGATTATTGCAGGCACAACCATTGGAGCAGGTATGCTTGCTATGCCGCT
TACATCAGCGGGTATGGGCTTTGGTTATACCCTGTTATTGCTCGTTGGCTTGTGGGCCTTGTTGGTTTACAGCGGATTGT
TGTTTGTAGAAGTGTATCAAACAGCGGATCAGTTGGATGATGGTGTTGCCACGCTCGCTGAAAAATATTTTGGGGCTCCT
GGGCGAATTTTAGCCACGTTGAGTTTGTTAGTTTTACTTTATGCACTTTCAGCCGCTTATATTACTGGTGGTGGATCTTT
ACTTTCAGGCTTGCCAACGGCTTTTGGAATGGACGCAATCTCACTTAAAACTGCAATTATTATTTTTACGGTGGTATTAG
GTTCTTTTGTCGTTGTAGGAACGAAAGGCGTGGATGGCTTAACTCGCGTGTTATTTATTGGTAAGTTAGTCGCCTTTGCT
TTTGTACTGTTTATGATGCTTCCAAAAGTAGCAACAGATAATTTAATGGCATTGCCTTTGGATTATGCTTTTGTGGTTTC
TGCGGCACCAATATTTTTTACTTCTTTCGGTTTCCACGTTATTATGGCGAGTGTGAATAGCTACTTAGGTGGAAGTGTTG
ATAAATTTCGTCGTGCCATTTTGATTGGTACTGCGATTCCATTAGCTGCTTACCTTGTATGGCAGTTAGCAACTCATGGT
GTATTAAGTCAAAGTGAATTTGTGCGTATTTTACAAGCTGACCCAACGCTAAATGGCTTAGTGAATGCAACACGTGAAAT
CACAAGTTCTCATTTTATGGGAGAGGTTGTGCGTGCGTTTTCATCACTTGCACTGATCACTTCTTTCTTAGGCGTAATGC
TTGGTGTATTTGAGGGATTGGGGGATTTATTCAAGCGTTATCATTTGCCAAATAATCGCTTTGTTTTAACTGTAGTCGCA
TTTTTACCGCCACTTGTATTTGCATTGTTTTATCCTGAAGGATTTATTACAGCATTAAGTTACGCAGGTTTATTGTGTGC
GTTCTATTGCTTAATTTTACCAATTGGCTTGGCATGGCGTACACGTATTGAAAATCCAACATTGCCATATCGTGTTTCTG
GCGGTAATTTCGCTTTGGTGTTTGCGTTATTAATTGGCGTCGTGATTATGCTCATTCCATTTTTAATTCAATGGGGATAT
TTACCAGTGGTGGCGGGGTAA

Upstream 100 bases:

>100_bases
AGGCAATGATTCTTATCTTTCTGTTTGCCGTTTACACTATAAAGAAAAGTGCGGTCAAATTTAAATTAGTTTTTAAACAC
AACATTATAAGGACAATTTT

Downstream 100 bases:

>100_bases
TATTTGATTTTTCCCTAGAGAAAACACTTTTCTTCCTCTGTTTGCAGGGGAGCTGCGAAGGTTGAGGGGAGATATAGAAA
GCCCCCTTCCGCCCTTCGGG

Product: tyrosine-specific transport protein 2

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 2 [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGAP
GRILATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAISLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLVAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITSSHFMGEVVRAFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTVVA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWRTRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGY
LPVVAG

Sequences:

>Translated_406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGAP
GRILATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAISLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLVAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITSSHFMGEVVRAFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTVVA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWRTRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGY
LPVVAG
>Mature_406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGAP
GRILATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAISLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLVAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITSSHFMGEVVRAFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTVVA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWRTRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGY
LPVVAG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=46.6501240694789, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790145, Length=402, Percent_Identity=28.6069651741293, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789552, Length=389, Percent_Identity=27.7634961439589, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43438; Mature: 43438

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQ
CCCCCCCCCEEEEECCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TADQLDDGVATLAEKYFGAPGRILATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHCCHHH
SLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLVAFAFVLFMMLPKVATDNLMALPL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
DYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VLSQSEFVRILQADPTLNGLVNATREITSSHFMGEVVRAFSSLALITSFLGVMLGVFEGL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLFKRYHLPNNRFVLTVVAFLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGYLPVVAG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQ
CCCCCCCCCEEEEECCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TADQLDDGVATLAEKYFGAPGRILATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMDAI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHCCHHH
SLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLVAFAFVLFMMLPKVATDNLMALPL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
DYAFVVSAAPIFFTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VLSQSEFVRILQADPTLNGLVNATREITSSHFMGEVVRAFSSLALITSFLGVMLGVFEGL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLFKRYHLPNNRFVLTVVAFLPPLVFALFYPEGFITALSYAGLLCAFYCLILPIGLAWR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRIENPTLPYRVSGGNFALVFALLIGVVIMLIPFLIQWGYLPVVAG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]