Click here to switch to the map view.

The map label for this gene is trpS

Identifier: 148824542

GI number: 148824542

Start: 3734948

End: 3735958

Strand: Reverse

Name: trpS

Synonym: TBFG_13369

Alternate gene names: 148824542

Gene position: 3735958-3734948 (Counterclockwise)

Preceding gene: 148824544

Following gene: 148824541

Centisome position: 84.44

GC content: 63.3

Gene sequence:

>1011_bases
ATGAGCACCCCTACCGGGTCCCGCCGGATCTTCTCCGGCGTGCAGCCCACGTCTGACTCGCTTCACCTCGGTAATGCCTT
GGGCGCCGTCGCCCAATGGGTTGGCTTGCAGGATGACCACGATGCGTTCTTCTGCGTGGTCGACCTGCATGCGATCACCA
TCCCTCAGGATCCCGAGGCACTGCGGCGCCGGACCCTGATTACCGCCGCGCAATACCTGGCGTTGGGAATCGATCCCGGC
CGCGCCACCATCTTCGTGCAAAGTCAGGTGCCGGCTCACACCCAGCTGGCGTGGGTGCTGGGTTGTTTCACCGGCTTTGG
CCAGGCGTCGCGGATGACCCAGTTCAAAGACAAGTCGGCGCGTCAGGGCAGCGAGGCCACCACCGTCGGCCTGTTCACCT
ACCCGGTACTGCAGGCCGCGGACGTGTTGGCCTACGACACCGAGCTGGTGCCCGTCGGGGAGGATCAGCGGCAGCACCTC
GAGCTGGCCCGCGACGTCGCGCAACGGTTCAACAGCCGATTCCCCGGCACCCTGGTGGTTCCCGACGTGCTCATCCCCAA
GATGACCGCCAAAATCTACGATCTACAAGACCCGACGTCAAAGATGAGCAAATCGGCGGGCACCGATGCCGGTTTGATCA
ACCTGCTCGACGATCCGGCATTGTCCGCCAAGAAGATTCGCTCCGCCGTGACCGACAGCGAACGTGACATCCGCTATGAC
CCGGACGTCAAGCCAGGGGTGTCTAACCTGTTGAACATCCAGTCGGCGGTCACCGGGACCGACATCGACGTTCTCGTCGA
CGGCTATGCCGGACACGGCTACGGCGATTTGAAGAAAGACACCGCCGAGGCCGTCGTCGAATTCGTCAACCCGATCCAAG
CCAGAGTTGACGAATTGACCGCAGATCCCGCGGAGCTGGAGGCCGTGCTCGCCGCCGGGGCGCAGCGCGCCCACGATGTG
GCCAGCAAAACGGTTCAGCGAGTCTACGATCGGCTCGGGTTCCTTCTATAA

Upstream 100 bases:

>100_bases
GCATAGAGCCGACACTAAAGCCGGTACCGCCGGTACCGCAAGCAGCGTGGTGACCGGTGGTCGACGGGGAGGGCACCCCG
CGTGAAAGGATCGGGGCATC

Downstream 100 bases:

>100_bases
CGGGGGTAGGGCAGTCGATCATGGGCGACCTCGCCGAGCCAGGGGTGCTTGACCGGCTGCGGGCCCGGTTCGGGTGGTTG
GACCATGTCGTGCGTGCGTT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSTPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQDPEALRRRTLITAAQYLALGIDPG
RATIFVQSQVPAHTQLAWVLGCFTGFGQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHL
ELARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDDPALSAKKIRSAVTDSERDIRYD
PDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGAQRAHDV
ASKTVQRVYDRLGFLL

Sequences:

>Translated_336_residues
MSTPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQDPEALRRRTLITAAQYLALGIDPG
RATIFVQSQVPAHTQLAWVLGCFTGFGQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHL
ELARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDDPALSAKKIRSAVTDSERDIRYD
PDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGAQRAHDV
ASKTVQRVYDRLGFLL
>Mature_335_residues
STPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQDPEALRRRTLITAAQYLALGIDPGR
ATIFVQSQVPAHTQLAWVLGCFTGFGQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHLE
LARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDDPALSAKKIRSAVTDSERDIRYDP
DVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGAQRAHDVA
SKTVQRVYDRLGFLL

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=331, Percent_Identity=42.9003021148036, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI41352700, Length=181, Percent_Identity=49.171270718232, Blast_Score=185, Evalue=4e-47,
Organism=Escherichia coli, GI1789786, Length=328, Percent_Identity=51.8292682926829, Blast_Score=332, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI71982800, Length=341, Percent_Identity=36.0703812316716, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71982793, Length=341, Percent_Identity=36.0703812316716, Blast_Score=203, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6320474, Length=344, Percent_Identity=38.0813953488372, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24666151, Length=329, Percent_Identity=42.5531914893617, Blast_Score=258, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_MYCBO (P67591)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_857014.1
- ProteinModelPortal:   P67591
- SMR:   P67591
- EnsemblBacteria:   EBMYCT00000015894
- GeneID:   1093742
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3369c
- GeneTree:   EBGT00050000017280
- HOGENOM:   HBG293263
- OMA:   NKPGVSN
- ProtClustDB:   PRK00927
- BioCyc:   MBOV233413:MB3369C-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 36272; Mature: 36141

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQDPEA
CCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCHHH
LRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFTGFGQASRMTQFKDKSA
HHHHHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHLELARDVAQRFNSRFPGTLVV
CCCCCCEEEEHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEC
PDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDDPALSAKKIRSAVTDSERDIRYD
CHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCC
PDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELT
CCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
ADPAELEAVLAAGAQRAHDVASKTVQRVYDRLGFLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQDPEA
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCHHH
LRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFTGFGQASRMTQFKDKSA
HHHHHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHLELARDVAQRFNSRFPGTLVV
CCCCCCEEEEHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEC
PDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDDPALSAKKIRSAVTDSERDIRYD
CHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCC
PDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELT
CCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
ADPAELEAVLAAGAQRAHDVASKTVQRVYDRLGFLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972