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The map label for this gene is icd

Identifier: 148824544

GI number: 148824544

Start: 3736942

End: 3738171

Strand: Reverse

Name: icd

Synonym: TBFG_13371

Alternate gene names: 148824544

Gene position: 3738171-3736942 (Counterclockwise)

Preceding gene: 148824545

Following gene: 148824542

Centisome position: 84.49

GC content: 59.76

Gene sequence:

>1230_bases
ATGTCCAACGCACCCAAGATAAAAGTCAGCGGTCCGGTCGTAGAGCTCGACGGTGACGAGATGACCCGTGTCATCTGGAA
GCTCATCAAGGACATGCTTATCCTTCCCTATCTCGACATCCGCTTGGACTATTACGACTTGGGCATCGAGCACCGCGACG
CCACCGACGACCAGGTGACGATCGACGCGGCGTATGCGATCAAGAAACACGGTGTGGGCGTAAAGTGCGCGACGATCACC
CCCGACGAGGCCCGTGTCGAGGAATTCAACCTGAAGAAGATGTGGCTGTCGCCCAATGGGACAATCCGGAACATCTTGGG
CGGCACAATCTTTCGCGAACCTATCGTGATTTCTAATGTGCCGCGACTGGTTCCGGGGTGGACCAAGCCGATCGTCATCG
GCCGGCACGCTTTTGGTGACCAATATCGGGCGACGAACTTCAAGGTCGACCAACCGGGCACCGTCACACTGACTTTCACG
CCCGCCGACGGCAGCGCGCCGATCGTGCACGAAATGGTGTCCATCCCCGAGGACGGCGGCGTCGTGCTGGGGATGTACAA
CTTCAAGGAATCCATCCGGGATTTCGCGCGCGCGTCGTTCTCCTACGGCCTCAACGCGAAATGGCCGGTATATCTGTCCA
CCAAGAACACCATCCTCAAGGCCTACGACGGGATGTTCAAAGACGAGTTCGAGCGCGTCTACGAAGAGGAATTCAAGGCG
CAGTTCGAAGCGGCGGGGCTGACCTACGAGCATCGGTTGATCGACGACATGGTCGCCGCCTGCCTGAAATGGGAAGGCGG
TTACGTCTGGGCGTGCAAGAACTACGACGGCGACGTGCAGTCGGACACCGTCGCACAGGGCTACGGCTCGCTGGGCCTGA
TGACGTCGGTGCTGATGACGGCCGACGGCAAGACAGTCGAGGCCGAAGCCGCCCACGGCACCGTCACCCGGCATTACCGG
CAGTATCAGGCCGGTAAACCGACCTCAACAAACCCGATCGCGTCGATCTTTGCCTGGACCCGCGGATTACAGCATCGCGG
CAAGCTGGATGGCACTCCCGAAGTCATCGACTTCGCCCACAAGCTGGAGTCCGTCGTCATCGCCACGGTGGAGAGCGGGA
AGATGACCAAGGACCTCGCGATCCTCATCGGTCCGGAGCAGGACTGGCTGAATAGCGAGGAATTCCTCGATGCGATCGCC
GACAACCTGGAAAAGGAGCTGGCCAATTAG

Upstream 100 bases:

>100_bases
ACTCAGTGCCAACTCAAAGCACAACTCCGGCGGTCTCAACTGGCCCTTTACCGGCCGCTAGGGGCCCGCGCGGGCTGCTA
GTAATCTGATGTGGACTCCC

Downstream 100 bases:

>100_bases
GGCGAGCAGACGCAAAATCGCCCAATTTCGTGCCGAAATGGGCGATTTTGCGTCTGCTCGCGCCCGCTAACTGGCCCGGA
CATGCGGGCAGCACTCTTCG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATIT
PDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFT
PADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKA
QFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYR
QYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIA
DNLEKELAN

Sequences:

>Translated_409_residues
MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATIT
PDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFT
PADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKA
QFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYR
QYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIA
DNLEKELAN
>Mature_408_residues
SNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATITP
DEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTP
ADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKAQ
FEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYRQ
YQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIAD
NLEKELAN

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family

Homologues:

Organism=Homo sapiens, GI28178825, Length=404, Percent_Identity=65.5940594059406, Blast_Score=560, Evalue=1e-160,
Organism=Homo sapiens, GI28178832, Length=409, Percent_Identity=65.0366748166259, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17550822, Length=400, Percent_Identity=65.5, Blast_Score=542, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17540874, Length=413, Percent_Identity=64.6489104116223, Blast_Score=537, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6323203, Length=405, Percent_Identity=62.2222222222222, Blast_Score=529, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6324319, Length=402, Percent_Identity=60.6965174129353, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320137, Length=408, Percent_Identity=62.0098039215686, Blast_Score=519, Evalue=1e-148,
Organism=Drosophila melanogaster, GI21356561, Length=411, Percent_Identity=65.4501216545012, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24660856, Length=411, Percent_Identity=65.4501216545012, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221330987, Length=411, Percent_Identity=65.4501216545012, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221330985, Length=411, Percent_Identity=65.4501216545012, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI28574947, Length=411, Percent_Identity=65.4501216545012, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24660849, Length=411, Percent_Identity=65.4501216545012, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221330983, Length=411, Percent_Identity=65.4501216545012, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24660868, Length=411, Percent_Identity=65.4501216545012, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24660860, Length=411, Percent_Identity=65.4501216545012, Blast_Score=539, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IDH_MYCBO (P65098)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_857016.1
- ProteinModelPortal:   P65098
- SMR:   P65098
- EnsemblBacteria:   EBMYCT00000015004
- GeneID:   1093830
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3371c
- GeneTree:   EBGT00050000017937
- HOGENOM:   HBG596047
- OMA:   TMKFVGE
- ProtClustDB:   PRK08299
- BioCyc:   MBOV233413:MB3371C-MONOMER
- BRENDA:   1.1.1.42
- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790
- Gene3D:   G3DSA:3.40.718.10
- PANTHER:   PTHR11822
- PIRSF:   PIRSF000108
- TIGRFAMs:   TIGR00127

Pfam domain/function: PF00180 Iso_dh

EC number: =1.1.1.42

Molecular weight: Translated: 45514; Mature: 45383

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00470 IDH_IMDH

Important sites: BINDING 80-80 BINDING 85-85 BINDING 112-112 BINDING 135-135 BINDING 263-263 BINDING 331-331

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVT
CCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEE
IDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNV
EEEEHHHHHCCCCEEEEEECCCHHHHHHCCCEEEEECCCCCHHHHHCCHHHCCCEEECCC
PRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADGSAPIVHEMVSIPEDGG
CCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCEEEEEEECCCCCCHHHHHHHCCCCCCC
VVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKA
EEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHHHH
QFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMT
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHH
ADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAH
CCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
KLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIADNLEKELAN
HHHHEEEEEECCCCCCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVT
CCCCEEEECCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEE
IDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNV
EEEEHHHHHCCCCEEEEEECCCHHHHHHCCCEEEEECCCCCHHHHHCCHHHCCCEEECCC
PRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADGSAPIVHEMVSIPEDGG
CCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCEEEEEEECCCCCCHHHHHHHCCCCCCC
VVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKA
EEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHHHH
QFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMT
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHH
ADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAH
CCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
KLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIADNLEKELAN
HHHHEEEEEECCCCCCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972