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The map label for this gene is lat

Identifier: 148824492

GI number: 148824492

Start: 3682160

End: 3683509

Strand: Reverse

Name: lat

Synonym: TBFG_13319

Alternate gene names: 148824492

Gene position: 3683509-3682160 (Counterclockwise)

Preceding gene: 148824493

Following gene: 148824491

Centisome position: 83.25

GC content: 64.74

Gene sequence:

>1350_bases
ATGGCCGCCGTCGTGAAGTCCGTCGCTCTTGCCGGTAGACCAACAACACCAGACCGGGTTCATGAGGTGCTAGGGCGCAG
CATGCTGGTCGACGGTCTGGACATAGTGCTCGATCTGACCCGTTCGGGCGGTTCATATCTGGTCGACGCTATAACGGGTC
GGCGCTACCTGGACATGTTCACATTCGTTGCCTCCTCGGCACTGGGTATGAATCCCCCGGCGCTGGTGGACGACCGGGAG
TTCCATGCCGAACTCATGCAGGCCGCGCTGAACAAGCCCAGCAATTCCGACGTGTACTCGGTGGCGATGGCCCGCTTCGT
CGAGACCTTCGCCCGTGTCTTGGGCGACCCGGCGCTGCCGCATCTGTTCTTCGTCGAAGGGGGCGCCCTGGCGGTGGAGA
ACGCGCTCAAAGCCGCGTTCGACTGGAAGAGTCGGCACAACCAAGCCCATGGGATCGACCCGGCGCTGGGCACTCAAGTG
CTCCACCTGCGCGGGGCATTTCACGGCCGCAGCGGCTATACCCTGTCGCTGACCAACACCAAGCCGACCATTACCGCCCG
GTTCCCGAAATTCGACTGGCCACGCATCGATGCGCCGTACATGCGGCCCGGCCTGGATGAGCCCGCTATGGCCGCGCTAG
AGGCCGAGGCGCTACGCCAGGCCCGCGCGGCATTCGAGACCCGCCCGCACGACATCGCGTGTTTTGTGGCCGAACCCATC
CAGGGCGAGGGTGGCGACCGCCATTTCCGCCCGGAGTTTTTCGCTGCGATGCGCGAGCTGTGCGACGAGTTTGATGCACT
GCTGATCTTCGACGAAGTACAGACCGGCTGCGGGTTGACCGGAACCGCCTGGGCATACCAGCAGTTGGATGTCGCACCCG
ACATCGTGGCGTTCGGCAAGAAGACGCAGGTATGCGGAGTGATGGCCGGTCGGCGGGTGGACGAGGTCGCCGACAATGTG
TTCGCGGTCCCATCACGGCTCAACTCGACATGGGGTGGCAATCTTACCGACATGGTGCGCGCCCGCCGCATCTTGGAGGT
CATCGAAGCCGAGGGCCTGTTCGAGCGGGCGGTGCAGCACGGTAAGTATCTGCGCGCCCGGCTTGACGAACTCGCCGCGG
ACTTCCCGGCAGTGGTTCTCGATCCGCGCGGCCGCGGGCTGATGTGTGCGTTTAGCCTGCCGACCACCGCCGACCGTGAC
GAGTTGATCCGCCAGCTGTGGCAACGTGCGGTGATTGTGTTGCCGGCCGGTGCAGACACCGTGCGATTCCGTCCACCGCT
GACGGTTTCAACCGCCGAGATCGACGCCGCGATAGCCGCGGTGCGCAGCGCGTTACCGGTGGTGACGTAA

Upstream 100 bases:

>100_bases
GCACGATCATTCTGAACACTTTTTACAGCGATAGGCAGCATATACCATAATTTTTCCAGCATAAATATCAATATTCCGTA
AATCCTGCTATCATAGCGTC

Downstream 100 bases:

>100_bases
GGCAGCCGCCAAGAGCGGGATGGAGATTCGCCGATGCACGAAGTAGGTGGGCCGTCACGCGGCGATCGGCTAGGCCGGGA
TGACAGCGAGGTGCACTCGG

Product: L-lysine aminotransferase

Products: NA

Alternate protein names: L-lysine aminotransferase; Lysine 6-aminotransferase

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDRE
FHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQV
LHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPI
QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNV
FAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRD
ELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT

Sequences:

>Translated_449_residues
MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDRE
FHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQV
LHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPI
QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNV
FAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRD
ELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT
>Mature_448_residues
AAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREF
HAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVL
HLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPIQ
GEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVF
AVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDE
LIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI188536080, Length=444, Percent_Identity=28.6036036036036, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI38679950, Length=444, Percent_Identity=28.6036036036036, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI38679946, Length=444, Percent_Identity=28.6036036036036, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI4557809, Length=417, Percent_Identity=28.2973621103118, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI13994255, Length=434, Percent_Identity=27.6497695852535, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=30.5810397553517, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI24119277, Length=437, Percent_Identity=24.7139588100687, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=23.0769230769231, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789016, Length=404, Percent_Identity=31.9306930693069, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI145693181, Length=332, Percent_Identity=32.2289156626506, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=29.7766749379653, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=27.75, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1787560, Length=411, Percent_Identity=29.683698296837, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786349, Length=323, Percent_Identity=27.2445820433437, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786991, Length=401, Percent_Identity=23.9401496259352, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17541228, Length=446, Percent_Identity=30.9417040358744, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI25144271, Length=406, Percent_Identity=26.3546798029557, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=312, Percent_Identity=28.525641025641, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=448, Percent_Identity=25, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=441, Percent_Identity=22.9024943310658, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321456, Length=465, Percent_Identity=29.6774193548387, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324432, Length=425, Percent_Identity=27.5294117647059, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6323470, Length=416, Percent_Identity=27.1634615384615, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324386, Length=251, Percent_Identity=27.8884462151394, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281366494, Length=435, Percent_Identity=29.4252873563218, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24667139, Length=435, Percent_Identity=29.4252873563218, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24667143, Length=435, Percent_Identity=29.4252873563218, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=29.2978208232446, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21356575, Length=439, Percent_Identity=26.4236902050114, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28574759, Length=440, Percent_Identity=24.7727272727273, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=25.5172413793103, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LAT_MYCBO (P63510)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_856963.1
- ProteinModelPortal:   P63510
- SMR:   P63510
- EnsemblBacteria:   EBMYCT00000016000
- GeneID:   1093883
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3318c
- GeneTree:   EBGT00050000015339
- HOGENOM:   HBG483813
- OMA:   SALGMNH
- ProtClustDB:   PRK08297
- BioCyc:   MBOV233413:MB3318C-MONOMER
- BRENDA:   2.6.1.36
- InterPro:   IPR005814
- InterPro:   IPR017657
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR03251

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.36

Molecular weight: Translated: 49013; Mature: 48881

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMF
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHEEEECCCCCCEEEEHHHCHHHHHHH
TFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALP
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
HLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNT
EEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCC
KPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPI
CCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGK
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCCCHHHHHHHCCCCHHHHCCC
KTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQH
CCHHHHHHHCCHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADT
HHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCC
VRFRPPLTVSTAEIDAAIAAVRSALPVVT
EEECCCCEEEHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMF
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHEEEECCCCCCEEEEHHHCHHHHHHH
TFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALP
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
HLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNT
EEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCC
KPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPI
CCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGK
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCCCHHHHHHHCCCCHHHHCCC
KTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQH
CCHHHHHHHCCHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADT
HHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCC
VRFRPPLTVSTAEIDAAIAAVRSALPVVT
EEECCCCEEEHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972