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The map label for this gene is mmr

Identifier: 148824257

GI number: 148824257

Start: 3442151

End: 3442474

Strand: Direct

Name: mmr

Synonym: TBFG_13082

Alternate gene names: 148824257

Gene position: 3442151-3442474 (Clockwise)

Preceding gene: 148824255

Following gene: 148824258

Centisome position: 77.8

GC content: 59.88

Gene sequence:

>324_bases
TTGATCTACCTATACCTCTTGTGCGCGATCTTCGCGGAAGTGGTGGCAACCAGCCTGCTCAAAAGCACGGAAGGGTTCAC
TCGGTTGTGGCCCACGGTGGGCTGTCTAGTGGGTTATGGCATCGCTTTCGCGCTGCTGGCCTTGTCGATCTCGCACGGCA
TGCAGACGGACGTCGCCTATGCGCTGTGGTCGGCAATCGGTACGGCCGCCATTGTGCTGGTCGCCGTACTGTTTCTCGGC
TCGCCGATATCTGTGATGAAGGTGGTTGGCGTCGGCCTGATTGTCGTCGGCGTGGTCACGTTGAACCTGGCGGGTGCCCA
TTGA

Upstream 100 bases:

>100_bases
GGCGGATTTTGTCTCCCACCGGTGTGCCTACTCACGTGTGGACGCACGAGCCTCCTTTGTGTACATTTGTACATGTACAA
ATGTACACAAAGGAGGGGTC

Downstream 100 bases:

>100_bases
CCGCAGGCTCCGACCGCCGTCCACGCGACCCAGCCGGTCGCCGGCAGGCGATCGTCGAGGCGGCCGAGCGCGTGATCGCT
CGCCAGGGCCTTGGCGGGCT

Product: multi-drug transport integral membrane protein mmr

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MIYLYLLCAIFAEVVATSLLKSTEGFTRLWPTVGCLVGYGIAFALLALSISHGMQTDVAYALWSAIGTAAIVLVAVLFLG
SPISVMKVVGVGLIVVGVVTLNLAGAH

Sequences:

>Translated_107_residues
MIYLYLLCAIFAEVVATSLLKSTEGFTRLWPTVGCLVGYGIAFALLALSISHGMQTDVAYALWSAIGTAAIVLVAVLFLG
SPISVMKVVGVGLIVVGVVTLNLAGAH
>Mature_107_residues
MIYLYLLCAIFAEVVATSLLKSTEGFTRLWPTVGCLVGYGIAFALLALSISHGMQTDVAYALWSAIGTAAIVLVAVLFLG
SPISVMKVVGVGLIVVGVVTLNLAGAH

Specific function: Multidrug efflux pump. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. Mmr (TC 2.A.7.1.2) subfamily

Homologues:

Organism=Escherichia coli, GI1786755, Length=101, Percent_Identity=43.5643564356436, Blast_Score=83, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MMR_MYCBO (P69927)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856737.1
- ProteinModelPortal:   P69927
- EnsemblBacteria:   EBMYCT00000015115
- GeneID:   1093511
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3092
- GeneTree:   EBGT00050000017346
- HOGENOM:   HBG740972
- OMA:   IAIISEV
- ProtClustDB:   CLSK799381
- BioCyc:   MBOV233413:MB3092-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000390

Pfam domain/function: PF00893 Multi_Drug_Res

EC number: NA

Molecular weight: Translated: 11084; Mature: 11084

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d231a10)-; HASH(0x1acba3e4)-; HASH(0x1d4d2900)-; HASH(0x1d2400ec)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLYLLCAIFAEVVATSLLKSTEGFTRLWPTVGCLVGYGIAFALLALSISHGMQTDVAY
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALWSAIGTAAIVLVAVLFLGSPISVMKVVGVGLIVVGVVTLNLAGAH
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MIYLYLLCAIFAEVVATSLLKSTEGFTRLWPTVGCLVGYGIAFALLALSISHGMQTDVAY
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALWSAIGTAAIVLVAVLFLGSPISVMKVVGVGLIVVGVVTLNLAGAH
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972