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The map label for this gene is ung

Identifier: 148824166

GI number: 148824166

Start: 3343544

End: 3344227

Strand: Reverse

Name: ung

Synonym: TBFG_12991

Alternate gene names: 148824166

Gene position: 3344227-3343544 (Counterclockwise)

Preceding gene: 148824167

Following gene: 148824164

Centisome position: 75.59

GC content: 67.11

Gene sequence:

>684_bases
GTGACCGCACGGCCGTTGAGTGAGCTCGTCGAGCGGGGGTGGGCCGCCGCGCTCGAGCCGGTGGCCGACCAGGTGGCCCA
CATGGGGCAGTTCTTGCGGGCCGAGATCGCGGCCGGGCGCAGATACCTGCCCGCCGGATCGAATGTGTTGCGCGCCTTCA
CTTTCCCGTTCGACAACGTCCGTGTCCTTATCGTTGGCCAAGACCCTTATCCGACTCCAGGACATGCTGTGGGTCTTAGC
TTCTCGGTGGCCCCTGATGTACGTCCGTGGCCGCGCAGTCTGGCCAACATCTTCGACGAGTACACCGCGGATTTGGGCTA
TCCGCTGCCCTCGAACGGCGATCTGACGCCCTGGGCGCAACGCGGTGTGTTGCTGTTGAACAGGGTGCTGACGGTGCGAC
CCAGCAACCCGGCGTCGCACCGGGGCAAGGGCTGGGAAGCGGTCACGGAATGCGCGATTCGCGCCCTGGCGGCGCGCGCA
GCGCCGCTGGTGGCGATCCTGTGGGGTCGTGACGCGTCGACTCTGAAGCCGATGCTGGCCGCGGGCAACTGCGTTGCGAT
CGAGTCGCCGCATCCTTCACCGCTATCGGCATCGCGCGGGTTCTTCGGCTCGCGTCCGTTCAGCCGCGCCAACGAACTGC
TCGTCGGGATGGGTGCCGAGCCGATCGATTGGCGGTTGCCCTGA

Upstream 100 bases:

>100_bases
AGGAGTGGACTGGATACGCGGGCTGGCAATCGTTTGGGGAGCCAGACAATCAAGGTTCGCTAGGGTGACGCGGTGACCGT
CTGTACGCGAAAGGGATGCA

Downstream 100 bases:

>100_bases
GTCGTGCAGGTGTTACCGGGCGTCAGCCGCGGGTGATCTTGCCCGCCTTGATGCAGGATGTGCAAACGTTGAGTCGCTTC
TTGTTGCCGCCGGGACGGGT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLS
FSVAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARA
APLVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPIDWRLP

Sequences:

>Translated_227_residues
MTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLS
FSVAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARA
APLVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPIDWRLP
>Mature_226_residues
TARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSF
SVAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAA
PLVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPIDWRLP

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=168, Percent_Identity=45.8333333333333, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI6224979, Length=170, Percent_Identity=45.2941176470588, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1788934, Length=197, Percent_Identity=41.1167512690355, Blast_Score=141, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17556304, Length=223, Percent_Identity=36.7713004484305, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323620, Length=216, Percent_Identity=39.8148148148148, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_MYCBO (P67072)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856645.1
- ProteinModelPortal:   P67072
- SMR:   P67072
- EnsemblBacteria:   EBMYCT00000014806
- GeneID:   1093730
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3000c
- GeneTree:   EBGT00050000017143
- HOGENOM:   HBG605450
- OMA:   VMLLNRV
- ProtClustDB:   PRK05254
- BioCyc:   MBOV233413:MB3000C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24481; Mature: 24350

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 68-68

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSNVLRAFTFPFDNV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCE
RVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQ
EEEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAPLVAILWGRDASTLKPMLA
HHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHH
AGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPIDWRLP
CCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHEEEECCCCCCCCCCC
>Mature Secondary Structure 
TARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSNVLRAFTFPFDNV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCE
RVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQ
EEEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAPLVAILWGRDASTLKPMLA
HHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHH
AGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPIDWRLP
CCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972