| Definition | Mycobacterium tuberculosis F11, complete genome. |
|---|---|
| Accession | NC_009565 |
| Length | 4,424,435 |
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The map label for this gene is fabG [H]
Identifier: 148823954
GI number: 148823954
Start: 3087543
End: 3088325
Strand: Reverse
Name: fabG [H]
Synonym: TBFG_12779
Alternate gene names: 148823954
Gene position: 3088325-3087543 (Counterclockwise)
Preceding gene: 148823955
Following gene: 148823952
Centisome position: 69.8
GC content: 66.41
Gene sequence:
>783_bases ATGACCTCACTGGATCTGACCGGCCGCACCGCCATAATTACTGGCGCATCGCGAGGCATCGGGCTTGCCATCGCCCAACA GCTGGCAGCTGCCGGCGCCCATGTGGTGCTCACCGCACGCAGGCAGGAAGCTGCCGACGAGGCTGCTGCACAGGTCGGCG ACCGCGCCCTGGGCGTTGGTGCACACGCGGTCGACGAGGATGCCGCCCGGCGTTGTGTGGACCTCACCCTCGAGCGCTTC GGCAGCGTTGACATCCTGATCAACAACGCCGGAACCAACCCGGCTTACGGTCCGCTGCTCGAGCAGGACCACGCCCGCTT CGCCAAGATCTTCGACGTCAACCTGTGGGCACCGCTGATGTGGACCTCGCTCGTCGTGACGGCGTGGATGGGCGAGCACG GCGGCGCGGTGGTCAACACCGCCTCCATCGGCGGGATGCACCAGTCCCCGGCCATGGGCATGTACAACGCGACCAAAGCC GCGCTGATCCACGTCACCAAGCAGCTGGCGCTGGAGCTTTCACCGCGCATCCGGGTGAATGCGATCTGTCCCGGGGTGGT TCGCACCAGGCTTGCCGAGGCGCTGTGGAAGGACCACGAGGATCCGTTGGCGGCGACCATTGCGCTCGGACGAATCGGGG AGCCGGCCGACATAGCGAGCGCGGTCGCGTTCCTGGTTTCGGATGCCGCAAGCTGGATCACCGGCGAAACCATGATCATC GACGGCGGTCTACTGCTCGGCAACGCGCTGGGATTCCGGGCCGCACCCAGCACTGAGCATTGA
Upstream 100 bases:
>100_bases GTTTGATTTCGCTAGCATTCTTGTCGCATACGGTGCGGGGGCGCTACCGACGCTCCCCGCCGGCGGAGTCCGGCCACCAC AGCAACCGAAGGCAAGCCAA
Downstream 100 bases:
>100_bases CCGCGCCGGTGTAGGGGCGCCTTTGCCCCGTGGAAAGTGCGTCCACGCACTGCCGCGGACGCAACTCGACGCGTAGCTCG CGGGGCGCACCGCGGACCGG
Product: 3-ketoacyl-(acyl-carrier-protein) reductase
Products: NA
Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]
Number of amino acids: Translated: 260; Mature: 259
Protein sequence:
>260_residues MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERF GSVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVNTASIGGMHQSPAMGMYNATKA ALIHVTKQLALELSPRIRVNAICPGVVRTRLAEALWKDHEDPLAATIALGRIGEPADIASAVAFLVSDAASWITGETMII DGGLLLGNALGFRAAPSTEH
Sequences:
>Translated_260_residues MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERF GSVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVNTASIGGMHQSPAMGMYNATKA ALIHVTKQLALELSPRIRVNAICPGVVRTRLAEALWKDHEDPLAATIALGRIGEPADIASAVAFLVSDAASWITGETMII DGGLLLGNALGFRAAPSTEH >Mature_259_residues TSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFG SVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVNTASIGGMHQSPAMGMYNATKAA LIHVTKQLALELSPRIRVNAICPGVVRTRLAEALWKDHEDPLAATIALGRIGEPADIASAVAFLVSDAASWITGETMIID GGLLLGNALGFRAAPSTEH
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=39.2, Blast_Score=180, Evalue=1e-45, Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=37.246963562753, Blast_Score=152, Evalue=2e-37, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=35.1778656126482, Blast_Score=139, Evalue=2e-33, Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=37.1134020618557, Blast_Score=125, Evalue=4e-29, Organism=Homo sapiens, GI126723191, Length=199, Percent_Identity=37.6884422110553, Blast_Score=120, Evalue=2e-27, Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=31.3807531380753, Blast_Score=119, Evalue=2e-27, Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=32.0158102766798, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI7705925, Length=253, Percent_Identity=34.7826086956522, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=34.5991561181435, Blast_Score=99, Evalue=3e-21, Organism=Homo sapiens, GI10190704, Length=261, Percent_Identity=30.2681992337165, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI31542939, Length=246, Percent_Identity=27.6422764227642, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=28.90625, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=31.9066147859922, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=27.0588235294118, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI302344755, Length=115, Percent_Identity=40, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=31.3492063492063, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI7706318, Length=203, Percent_Identity=30.5418719211823, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI7705855, Length=243, Percent_Identity=24.6913580246914, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI210032110, Length=192, Percent_Identity=30.2083333333333, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI226371731, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI66933014, Length=246, Percent_Identity=26.0162601626016, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI224922801, Length=175, Percent_Identity=26.8571428571429, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI32455239, Length=165, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI5031765, Length=165, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI142976729, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=8e-11, Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=35.2459016393443, Blast_Score=139, Evalue=2e-34, Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=36.6141732283465, Blast_Score=126, Evalue=1e-30, Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=32.7935222672065, Blast_Score=117, Evalue=1e-27, Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=31.7829457364341, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=28.1124497991968, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=31.4516129032258, Blast_Score=99, Evalue=4e-22, Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=33.7448559670782, Blast_Score=98, Evalue=4e-22, Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=27.4509803921569, Blast_Score=94, Evalue=7e-21, Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=29.2, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=30.5343511450382, Blast_Score=83, Evalue=1e-17, Organism=Escherichia coli, GI2367175, Length=243, Percent_Identity=29.2181069958848, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1787526, Length=244, Percent_Identity=27.8688524590164, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI1786701, Length=198, Percent_Identity=28.2828282828283, Blast_Score=68, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=40.9638554216867, Blast_Score=188, Evalue=3e-48, Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=39.5918367346939, Blast_Score=173, Evalue=1e-43, Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=36.1788617886179, Blast_Score=127, Evalue=5e-30, Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=34.0080971659919, Blast_Score=119, Evalue=1e-27, Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=31.9548872180451, Blast_Score=117, Evalue=4e-27, Organism=Caenorhabditis elegans, GI193204405, Length=273, Percent_Identity=31.8681318681319, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=35.2059925093633, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=30.9917355371901, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17562908, Length=269, Percent_Identity=31.5985130111524, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=32.1969696969697, Blast_Score=107, Evalue=5e-24, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=32.1969696969697, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=31.9702602230483, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=34.6863468634686, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=31.5384615384615, Blast_Score=103, Evalue=7e-23, Organism=Caenorhabditis elegans, GI17560220, Length=268, Percent_Identity=28.7313432835821, Blast_Score=103, Evalue=8e-23, Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=29.3436293436293, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=32.7868852459016, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=30.5343511450382, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17538480, Length=274, Percent_Identity=32.1167883211679, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=30.5343511450382, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17565030, Length=271, Percent_Identity=33.5793357933579, Blast_Score=98, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17508651, Length=247, Percent_Identity=27.1255060728745, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=29.6296296296296, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=28.4132841328413, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17538182, Length=261, Percent_Identity=29.5019157088123, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17561272, Length=250, Percent_Identity=31.2, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=28.8, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17536025, Length=250, Percent_Identity=29.2, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17555612, Length=275, Percent_Identity=29.8181818181818, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI25152911, Length=233, Percent_Identity=28.3261802575107, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17508895, Length=197, Percent_Identity=27.4111675126904, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17558006, Length=208, Percent_Identity=27.8846153846154, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI71997099, Length=209, Percent_Identity=29.6650717703349, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI193203117, Length=200, Percent_Identity=27, Blast_Score=64, Evalue=6e-11, Organism=Caenorhabditis elegans, GI193203115, Length=199, Percent_Identity=27.1356783919598, Blast_Score=64, Evalue=7e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=274, Percent_Identity=26.6423357664234, Blast_Score=85, Evalue=1e-17, Organism=Saccharomyces cerevisiae, GI6323882, Length=247, Percent_Identity=26.7206477732794, Blast_Score=80, Evalue=4e-16, Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=27.4881516587678, Blast_Score=72, Evalue=7e-14, Organism=Saccharomyces cerevisiae, GI6322067, Length=188, Percent_Identity=31.9148936170213, Blast_Score=72, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6322226, Length=186, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=3e-12, Organism=Drosophila melanogaster, GI21355319, Length=245, Percent_Identity=36.734693877551, Blast_Score=166, Evalue=1e-41, Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=34.9593495934959, Blast_Score=126, Evalue=1e-29, Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=34.5381526104418, Blast_Score=123, Evalue=9e-29, Organism=Drosophila melanogaster, GI24644337, Length=251, Percent_Identity=33.8645418326693, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=33.596837944664, Blast_Score=119, Evalue=1e-27, Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=35.4581673306773, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=36.144578313253, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=30.2040816326531, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI17737361, Length=248, Percent_Identity=27.8225806451613, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=30.0518134715026, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI24641232, Length=201, Percent_Identity=30.3482587064677, Blast_Score=75, Evalue=6e-14, Organism=Drosophila melanogaster, GI24640442, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI28574402, Length=200, Percent_Identity=28.5, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24584744, Length=200, Percent_Identity=28.5, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI281364494, Length=233, Percent_Identity=28.3261802575107, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24665243, Length=200, Percent_Identity=28.5, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24665247, Length=201, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24580925, Length=196, Percent_Identity=30.1020408163265, Blast_Score=67, Evalue=8e-12, Organism=Drosophila melanogaster, GI221331218, Length=198, Percent_Identity=28.2828282828283, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI221331216, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=29.1005291005291, Blast_Score=65, Evalue=3e-11, Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=29.1005291005291, Blast_Score=65, Evalue=3e-11, Organism=Drosophila melanogaster, GI116007234, Length=238, Percent_Identity=27.7310924369748, Blast_Score=65, Evalue=4e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011284 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.100 [H]
Molecular weight: Translated: 27140; Mature: 27009
Theoretical pI: Translated: 5.82; Mature: 5.82
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEAAAQVGDRALGVG CCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCHHHCCC AHAVDEDAARRCVDLTLERFGSVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLM CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHEECCCHHHHH WTSLVVTAWMGEHGGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPRIRVN HHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE AICPGVVRTRLAEALWKDHEDPLAATIALGRIGEPADIASAVAFLVSDAASWITGETMII EECCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE DGGLLLGNALGFRAAPSTEH ECCEEECCCCCCCCCCCCCC >Mature Secondary Structure TSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEAAAQVGDRALGVG CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCHHHCCC AHAVDEDAARRCVDLTLERFGSVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLM CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHEECCCHHHHH WTSLVVTAWMGEHGGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPRIRVN HHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE AICPGVVRTRLAEALWKDHEDPLAATIALGRIGEPADIASAVAFLVSDAASWITGETMII EECCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE DGGLLLGNALGFRAAPSTEH ECCEEECCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8759840; 9384377; 9534248; 8654983 [H]