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The map label for this gene is 148823940

Identifier: 148823940

GI number: 148823940

Start: 3076470

End: 3078146

Strand: Reverse

Name: 148823940

Synonym: TBFG_12765

Alternate gene names: NA

Gene position: 3078146-3076470 (Counterclockwise)

Preceding gene: 148823941

Following gene: 148823937

Centisome position: 69.57

GC content: 63.63

Gene sequence:

>1677_bases
GTGGATGTAGACCTTCCCCCGCCAGGTCCCCTGACCTCCGGCGGGTTGCGGGTCACCGCGCTGGGCGGCATCAACGAAAT
CGGCCGCAACATGACGGTTTTCGAACACCTGGGCCGACTGTTGATTATCGACTGCGGTGTGTTGTTTCCTGGCCACGACG
AGCCCGGTGTCGATCTGATCCTGCCGGACATGCGCCATGTCGAAGACCGGCTTGACGACATCGAGGCGCTGGTGTTGACC
CACGGGCACGAGGACCACATCGGGGCGATTCCGTTTCTGCTCAAGCTGCGACCCGACATCCCGGTCGTCGGCTCGAAGTT
CACCTTGGCTCTGGTTGCAGAGAAATGTCGTGAGTACCGCATAACACCGGTGTTCGTCGAGGTCCGCGAGGGCCAGAGCA
CCCGGCACGGCGTGTTTGAGTGCGAGTACTTCGCCGTCAACCATTCCACTCCGGACGCGTTGGCCATCGCGGTGTATACC
GGCGCGGGAACCATCCTGCACACCGGCGACATCAAGTTCGACCAATTGCCACCGGACGGCCGTCCCACCGATCTACCGGG
CATGTCGCGGCTCGGCGACACCGGCGTGGACCTGTTGCTGTGCGACTCGACGAACGCCGAGATCCCCGGTGTCGGGCCAT
CGGAAAGCGAAGTGGGCCCAACGCTGCACCGGCTCATCCGGGGTGCCGACGGACGGGTGATAGTTGCGTGTTTCGCCTCC
AACGTGGATCGGGTACAGCAGATCATCGATGCCGCAGTGGCATTGGGCCGGCGAGTGTCGTTCGTCGGCCGATCGATGGT
GCGCAACATGCGCGTCGCAAGGCAACTGGGCTTCCTACGAGTGGCTGATTCCGATCTCATCGACATCGCCGCCGCCGAAA
CGATGGCGCCCGACCAAGTTGTGTTGATCACCACCGGCACCCAAGGCGAGCCGATGTCGGCGTTGTCGCGAATGTCGCGT
GGGGAGCATCGCAGCATCACGTTGACTGCTGGTGATCTCATCGTGTTGTCGTCGTCGCTGATCCCCGGCAACGAGGAGGC
GGTCTTCGGAGTCATCGATGCACTGTCCAAGATCGGCGCCAGAGTCGTCACCAACGCCCAAGCAAGGGTGCATGTTTCCG
GCCACGCGTACGCCGGTGAGCTGCTGTTCCTCTACAACGGGGTGCGGCCGCGCAACGTGATGCCGGTGCACGGAACCTGG
CGGATGCTGCGCGCCAATGCCAAGCTGGCCGCCAGTACCGGCGTACCGCAAGAGTCAATTCTGTTGGCCGAGAACGGTGT
CAGCGTCGACCTGGTTGCCGGCAAAGCCAGTATCTCCGGTGCGGTGCCGGTGGGCAAGATGTTCGTCGACGGCTTGATCG
CCGGCGACGTCGGCGATATCACCCTGGGCGAGCGGCTCATTTTGTCGTCGGGCTTTGTCGCGGTGACCGTCGTGGTCAGA
CGTGGCACCGGCCAGCCGTTGGCTGCGCCACATCTACACTCGCGGGGTTTCTCCGAAGATCCCAAGGCGCTCGAACCCGC
CGTGCGCAAGGTGGAGGCAGAGCTGGAATCGTTGGTGGCCGCCAACGTCACCGATCCGATCCGGATCGCTCAAGGGGTGC
GCCGCACGGTCGGCAAGTGGGTGGGGGAAACCTATCGCCGCCAGCCGATGATTGTGCCGACGGTCATCGAGGTGTAA

Upstream 100 bases:

>100_bases
GGTGGCCGCGACACCGGAGCAGATCGACGCGTTGGCCGCCGACATGCGCGCGGCCTCGGTGCTTCGGTGATCTAAAGGTG
AGCCAAAGGGTGGCCCAGAA

Downstream 100 bases:

>100_bases
CCGGCTCACTCTTCTCGGCGTAGGCAGACCACTCGATTTGTGATGCGTTGAGGTTGCGGCCGGTGGGCTCGACGTAGCGC
TGGACAAGCTCCTCCGGCCC

Product: hypothetical protein

Products: NA

Alternate protein names: RNase J

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MDVDLPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIIDCGVLFPGHDEPGVDLILPDMRHVEDRLDDIEALVLT
HGHEDHIGAIPFLLKLRPDIPVVGSKFTLALVAEKCREYRITPVFVEVREGQSTRHGVFECEYFAVNHSTPDALAIAVYT
GAGTILHTGDIKFDQLPPDGRPTDLPGMSRLGDTGVDLLLCDSTNAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFAS
NVDRVQQIIDAAVALGRRVSFVGRSMVRNMRVARQLGFLRVADSDLIDIAAAETMAPDQVVLITTGTQGEPMSALSRMSR
GEHRSITLTAGDLIVLSSSLIPGNEEAVFGVIDALSKIGARVVTNAQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTW
RMLRANAKLAASTGVPQESILLAENGVSVDLVAGKASISGAVPVGKMFVDGLIAGDVGDITLGERLILSSGFVAVTVVVR
RGTGQPLAAPHLHSRGFSEDPKALEPAVRKVEAELESLVAANVTDPIRIAQGVRRTVGKWVGETYRRQPMIVPTVIEV

Sequences:

>Translated_558_residues
MDVDLPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIIDCGVLFPGHDEPGVDLILPDMRHVEDRLDDIEALVLT
HGHEDHIGAIPFLLKLRPDIPVVGSKFTLALVAEKCREYRITPVFVEVREGQSTRHGVFECEYFAVNHSTPDALAIAVYT
GAGTILHTGDIKFDQLPPDGRPTDLPGMSRLGDTGVDLLLCDSTNAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFAS
NVDRVQQIIDAAVALGRRVSFVGRSMVRNMRVARQLGFLRVADSDLIDIAAAETMAPDQVVLITTGTQGEPMSALSRMSR
GEHRSITLTAGDLIVLSSSLIPGNEEAVFGVIDALSKIGARVVTNAQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTW
RMLRANAKLAASTGVPQESILLAENGVSVDLVAGKASISGAVPVGKMFVDGLIAGDVGDITLGERLILSSGFVAVTVVVR
RGTGQPLAAPHLHSRGFSEDPKALEPAVRKVEAELESLVAANVTDPIRIAQGVRRTVGKWVGETYRRQPMIVPTVIEV
>Mature_558_residues
MDVDLPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIIDCGVLFPGHDEPGVDLILPDMRHVEDRLDDIEALVLT
HGHEDHIGAIPFLLKLRPDIPVVGSKFTLALVAEKCREYRITPVFVEVREGQSTRHGVFECEYFAVNHSTPDALAIAVYT
GAGTILHTGDIKFDQLPPDGRPTDLPGMSRLGDTGVDLLLCDSTNAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFAS
NVDRVQQIIDAAVALGRRVSFVGRSMVRNMRVARQLGFLRVADSDLIDIAAAETMAPDQVVLITTGTQGEPMSALSRMSR
GEHRSITLTAGDLIVLSSSLIPGNEEAVFGVIDALSKIGARVVTNAQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTW
RMLRANAKLAASTGVPQESILLAENGVSVDLVAGKASISGAVPVGKMFVDGLIAGDVGDITLGERLILSSGFVAVTVVVR
RGTGQPLAAPHLHSRGFSEDPKALEPAVRKVEAELESLVAANVTDPIRIAQGVRRTVGKWVGETYRRQPMIVPTVIEV

Specific function: Unknown

COG id: COG0595

COG function: function code R; Predicted hydrolase of the metallo-beta-lactamase superfamily

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. RNase J subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2752_MYCTU (O33294)

Other databases:

- EMBL:   BX842580
- EMBL:   AE000516
- PIR:   G70879
- RefSeq:   NP_217268.1
- RefSeq:   NP_337327.1
- ProteinModelPortal:   O33294
- SMR:   O33294
- EnsemblBacteria:   EBMYCT00000001304
- EnsemblBacteria:   EBMYCT00000072038
- GeneID:   887802
- GeneID:   925467
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2822
- KEGG:   mtu:Rv2752c
- TIGR:   MT2822
- TubercuList:   Rv2752c
- GeneTree:   EBGT00050000017103
- HOGENOM:   HBG497378
- OMA:   HPRRNEL
- ProtClustDB:   CLSK792055
- GO:   GO:0005737
- InterPro:   IPR001279
- InterPro:   IPR011108
- SMART:   SM00849

Pfam domain/function: PF00753 Lactamase_B; PF07521 RMMBL

EC number: NA

Molecular weight: Translated: 59533; Mature: 59533

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS01292 UPF0036

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVDLPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIIDCGVLFPGHDEPGVDLI
CCCCCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHCCCEEEEEECEECCCCCCCCCEEE
LPDMRHVEDRLDDIEALVLTHGHEDHIGAIPFLLKLRPDIPVVGSKFTLALVAEKCREYR
CCCHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
ITPVFVEVREGQSTRHGVFECEYFAVNHSTPDALAIAVYTGAGTILHTGDIKFDQLPPDG
CCEEEEEEECCCCCCCCCEEEEEEEEECCCCCEEEEEEEECCCEEEEECCEEECCCCCCC
RPTDLPGMSRLGDTGVDLLLCDSTNAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFAS
CCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEECC
NVDRVQQIIDAAVALGRRVSFVGRSMVRNMRVARQLGFLRVADSDLIDIAAAETMAPDQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEHHHHHCCCCCCE
VLITTGTQGEPMSALSRMSRGEHRSITLTAGDLIVLSSSLIPGNEEAVFGVIDALSKIGA
EEEEECCCCCHHHHHHHHCCCCCCEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHCCC
RVVTNAQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTWRMLRANAKLAASTGVPQESI
EEEECCCEEEEECCCCCCCEEEEEECCCCCCCEEECCCCCEEEECCCEEEECCCCCHHEE
LLAENGVSVDLVAGKASISGAVPVGKMFVDGLIAGDVGDITLGERLILSSGFVAVTVVVR
EEECCCCEEEEEECCCCCCCCCCHHHHHHHHEEECCCCCCCCCCEEECCCCCEEEEEEEE
RGTGQPLAAPHLHSRGFSEDPKALEPAVRKVEAELESLVAANVTDPIRIAQGVRRTVGKW
CCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VGETYRRQPMIVPTVIEV
HHHHHHCCCCEECEEECC
>Mature Secondary Structure
MDVDLPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIIDCGVLFPGHDEPGVDLI
CCCCCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHCCCEEEEEECEECCCCCCCCCEEE
LPDMRHVEDRLDDIEALVLTHGHEDHIGAIPFLLKLRPDIPVVGSKFTLALVAEKCREYR
CCCHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
ITPVFVEVREGQSTRHGVFECEYFAVNHSTPDALAIAVYTGAGTILHTGDIKFDQLPPDG
CCEEEEEEECCCCCCCCCEEEEEEEEECCCCCEEEEEEEECCCEEEEECCEEECCCCCCC
RPTDLPGMSRLGDTGVDLLLCDSTNAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFAS
CCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEECC
NVDRVQQIIDAAVALGRRVSFVGRSMVRNMRVARQLGFLRVADSDLIDIAAAETMAPDQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEHHHHHCCCCCCE
VLITTGTQGEPMSALSRMSRGEHRSITLTAGDLIVLSSSLIPGNEEAVFGVIDALSKIGA
EEEEECCCCCHHHHHHHHCCCCCCEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHCCC
RVVTNAQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTWRMLRANAKLAASTGVPQESI
EEEECCCEEEEECCCCCCCEEEEEECCCCCCCEEECCCCCEEEECCCEEEECCCCCHHEE
LLAENGVSVDLVAGKASISGAVPVGKMFVDGLIAGDVGDITLGERLILSSGFVAVTVVVR
EEECCCCEEEEEECCCCCCCCCCHHHHHHHHEEECCCCCCCCCCEEECCCCCEEEEEEEE
RGTGQPLAAPHLHSRGFSEDPKALEPAVRKVEAELESLVAANVTDPIRIAQGVRRTVGKW
CCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VGETYRRQPMIVPTVIEV
HHHHHHCCCCEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036