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The map label for this gene is dapA

Identifier: 148823941

GI number: 148823941

Start: 3078177

End: 3079079

Strand: Reverse

Name: dapA

Synonym: TBFG_12766

Alternate gene names: 148823941

Gene position: 3079079-3078177 (Counterclockwise)

Preceding gene: 148823942

Following gene: 148823940

Centisome position: 69.59

GC content: 68.66

Gene sequence:

>903_bases
GTGACCACCGTCGGATTCGACGTCGCAGCGCGCCTAGGAACCCTGCTGACCGCGATGGTGACACCGTTTAGCGGCGATGG
CTCCCTGGACACCGCCACCGCGGCGCGGCTGGCCAACCACCTGGTCGATCAGGGGTGCGACGGTCTGGTGGTCTCGGGCA
CCACCGGCGAGTCGCCGACCACCACCGACGGGGAGAAAATCGAGCTGCTGCGGGCCGTCTTGGAAGCGGTGGGGGACCGG
GCCCGTGTTATCGCCGGTGCCGGCACCTATGACACCGCGCACAGCATCCGGCTGGCCAAGGCTTGTGCGGCCGAGGGTGC
GCACGGGCTGCTGGTGGTCACGCCCTACTATTCCAAGCCGCCGCAGCGGGGGCTGCAAGCCCATTTCACCGCCGTCGCCG
ACGCGACCGAGCTGCCGATGCTGCTCTATGACATCCCGGGGCGGTCGGCGGTGCCGATCGAGCCCGACACGATCCGCGCG
TTGGCGTCGCATCCGAACATCGTCGGAGTCAAGGACGCCAAAGCCGACCTGCACAGCGGCGCCCAAATCATGGCCGACAC
CGGACTGGCCTACTATTCCGGCGACGACGCGCTCAACCTGCCCTGGCTGGCCATGGGCGCCACGGGCTTCATCAGCGTGA
TTGCCCACCTGGCAGCCGGGCAGCTTCGAGAGTTGTTGTCCGCCTTCGGTTCTGGGGATATCGCCACCGCCCGCAAGATC
AACATTGCGGTCGCCCCGCTGTGCAACGCGATGAGCCGCCTGGGTGGGGTGACGTTGTCCAAGGCGGGCTTGCGGCTGCA
GGGCATCGACGTCGGTGATCCCCGGCTGCCCCAGGTGGCCGCGACACCGGAGCAGATCGACGCGTTGGCCGCCGACATGC
GCGCGGCCTCGGTGCTTCGGTGA

Upstream 100 bases:

>100_bases
TGGCGACCAGCCCGTTGGCGACCGAAGCCTGAGGCGGCGTGTCGCTGGACAAACACGCGCGCTCGCGGCCGGGATAAAGC
GCCAGGTAACCTTGGGAGCC

Downstream 100 bases:

>100_bases
TCTAAAGGTGAGCCAAAGGGTGGCCCAGAAGTGGATGTAGACCTTCCCCCGCCAGGTCCCCTGACCTCCGGCGGGTTGCG
GGTCACCGCGCTGGGCGGCA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDR
ARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRA
LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI
NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR

Sequences:

>Translated_300_residues
MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDR
ARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRA
LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI
NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
>Mature_299_residues
TTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDRA
RVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRAL
ASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKIN
IAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI13540533, Length=300, Percent_Identity=28, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI31543060, Length=286, Percent_Identity=26.5734265734266, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1788823, Length=238, Percent_Identity=36.5546218487395, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789620, Length=250, Percent_Identity=30, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87082415, Length=271, Percent_Identity=28.4132841328413, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1786463, Length=233, Percent_Identity=31.3304721030043, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_MYCBO (P63946)

Other databases:

- EMBL:   BX248343
- RefSeq:   NP_856420.1
- ProteinModelPortal:   P63946
- SMR:   P63946
- EnsemblBacteria:   EBMYCT00000015357
- GeneID:   1091633
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2774c
- GeneTree:   EBGT00050000016215
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- BioCyc:   MBOV233413:MB2774C-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 30859; Mature: 30727

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 171-171 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
TTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKP
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
PQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRALASHPNIVGVKDAKADLHSG
CHHHHHHHHHHHHCHHHCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHCC
AQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI
CEEEECCCEEEECCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
EEEHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPT
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
TTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKP
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
PQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRALASHPNIVGVKDAKADLHSG
CHHHHHHHHHHHHCHHHCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHCC
AQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI
CEEEECCCEEEECCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
EEEHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972