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The map label for this gene is hemE [H]

Identifier: 148823868

GI number: 148823868

Start: 3005893

End: 3006966

Strand: Reverse

Name: hemE [H]

Synonym: TBFG_12693

Alternate gene names: 148823868

Gene position: 3006966-3005893 (Counterclockwise)

Preceding gene: 148823872

Following gene: 148823867

Centisome position: 67.96

GC content: 69.46

Gene sequence:

>1074_bases
ATGAGTACCCGTCGCGACCTTCCGCAGTCGCCGTATCTGGCCGCCGTCACCGGCCGCAAGCCCAGCCGGGTGCCGGTGTG
GTTCATGCGGCAGGCCGGGCGCTCGTTGCCCGAATACCGGGCGCTGCGCGAGCGGTACAGCATGCTGGCGGCCTGTTTCG
AACCGGACGTGGCCTGTGAGATTACCCTGCAGCCGATACGCCGCTACGACGTCGACGCGGCCATCCTGTTCTCCGACATC
GTGGTGCCGCTACGGGCGGCCGGCGTGGATTTGGACATCGTCGCCGACGTTGGGCCGGTGATCGCGGACCCGGTGCGCAC
CGCCGCCGATGTCGCCGCCATGAAACCACTTGATCCACAAGCGATTCAACCGGTATTGGTGGCGGCTTCGTTGTTGGTCG
CTGAGCTTGGCGACGTGCCGCTGATCGGTTTCGCCGGCGCGCCGTTCACGCTGGCCTCCTACCTCGTGGAGGGCGGACCG
AGCCGCCATCACGCCCACGTCAAGGCGATGATGTTGGCCGAGCCGGCGAGCTGGCACGCGCTGATGGCCAAGCTGACCGA
CCTCACCATCGCGTTTCTGGTCGGCCAAATCGACGCGGGGGTGGACGCCATCCAGGTATTCGACTCCTGGGCCGGGGCGC
TCTCGCCGATCGACTACCGCCAGTACGTGTTGCCGCACAGCGCCCGGGTGTTCGCTGCGCTGGGCGAGCATGGCGTGCCG
ATGACGCACTTCGGGGTTGGGACCGCCGAATTGCTGGGCGCGATGTCGGAGGCCGTGACAGCCGGGGAGCGGCCAGGCCG
AGGGGCCGTCGTCGGCGTGGACTGGCGGACCCCGCTGACCGACGCCGCCGCCCGGGTGGTGCCCGGCACGGCGTTACAGG
GCAACCTCGATCCGGCGGTGGTCCTGGCGGGCTGGCCGGCGGTGGAACGTGCCGCACGTGCCGTTGTCGACGACGGACGC
CGCGCCGTCGACGCCGGTGCGGCCGGCCATATCTTCAACCTCGGCCACGGGGTGCTGCCAGAAAGCGATCCCGCGGTGCT
GGCCGACCTGGTCTCGCTCGTACACTCGCTATGA

Upstream 100 bases:

>100_bases
GTGGATTTCGCAGCGCAGGCTGGGGAAGTCGTCGTAGGTAACTGGCATTGGGTCGATGTTACGCAGGTGCGGGGTGGCGG
TCGTGGCAGCATTGAGTTCG

Downstream 100 bases:

>100_bases
CTCCCCGCTCGTATTGTGTTGTAGGAGGCGGGATTTCGGGATTGACCTCGGCGTACCGGCTGCGGCAGGCTGTCGGCGAT
GACGCGACCATCACCTTGTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSTRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACEITLQPIRRYDVDAAILFSDI
VVPLRAAGVDLDIVADVGPVIADPVRTAADVAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGP
SRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSWAGALSPIDYRQYVLPHSARVFAALGEHGVP
MTHFGVGTAELLGAMSEAVTAGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAVVLAGWPAVERAARAVVDDGR
RAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL

Sequences:

>Translated_357_residues
MSTRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACEITLQPIRRYDVDAAILFSDI
VVPLRAAGVDLDIVADVGPVIADPVRTAADVAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGP
SRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSWAGALSPIDYRQYVLPHSARVFAALGEHGVP
MTHFGVGTAELLGAMSEAVTAGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAVVLAGWPAVERAARAVVDDGR
RAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL
>Mature_356_residues
STRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACEITLQPIRRYDVDAAILFSDIV
VPLRAAGVDLDIVADVGPVIADPVRTAADVAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGPS
RHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSWAGALSPIDYRQYVLPHSARVFAALGEHGVPM
THFGVGTAELLGAMSEAVTAGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAVVLAGWPAVERAARAVVDDGRR
AVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=363, Percent_Identity=37.7410468319559, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI2367337, Length=359, Percent_Identity=38.9972144846797, Blast_Score=230, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6320252, Length=359, Percent_Identity=33.4261838440111, Blast_Score=198, Evalue=9e-52,
Organism=Drosophila melanogaster, GI221330099, Length=359, Percent_Identity=35.0974930362117, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI19921920, Length=359, Percent_Identity=35.0974930362117, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37607; Mature: 37475

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACE
CCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEE
ITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIADPVRTAADVAAMKPLDPQ
EEECHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCHH
AIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGPSRHHAHVKAMMLAEPASWHA
HHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCHHHHHEEEEEECCCHHHH
LMAKLTDLTIAFLVGQIDAGVDAIQVFDSWAGALSPIDYRQYVLPHSARVFAALGEHGVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHCCCCCC
MTHFGVGTAELLGAMSEAVTAGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAV
EEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCEE
VLAGWPAVERAARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL
EEECCHHHHHHHHHHHHCCCHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACE
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEE
ITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIADPVRTAADVAAMKPLDPQ
EEECHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCHH
AIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGPSRHHAHVKAMMLAEPASWHA
HHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCHHHHHEEEEEECCCHHHH
LMAKLTDLTIAFLVGQIDAGVDAIQVFDSWAGALSPIDYRQYVLPHSARVFAALGEHGVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHCCCCCC
MTHFGVGTAELLGAMSEAVTAGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAV
EEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCEE
VLAGWPAVERAARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL
EEECCHHHHHHHHHHHHCCCHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]