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The map label for this gene is PE_PGRS35 [H]

Identifier: 148823715

GI number: 148823715

Start: 2849103

End: 2850581

Strand: Direct

Name: PE_PGRS35 [H]

Synonym: TBFG_12540

Alternate gene names: 148823715

Gene position: 2849103-2850581 (Clockwise)

Preceding gene: 148823710

Following gene: 148823717

Centisome position: 64.39

GC content: 65.25

Gene sequence:

>1479_bases
GTGTCGCGTCTGATCGTGGCTCCGGACTGGCTGGCGTCAGCAGCGGCGGAGGTGCAAAGCATCGGCTCGGCGCTGAGCGC
GGCGAACGCCGCGGCCGCGGCCCCCACCACCCTATTGGTGGCCGCCGCCGAAGACGAGGTATCCGCAGCGGCCGCAGCGC
TATTCGCCAACTACGGCCGGGAGTATCAGACGCTGAGTGTGCGGTTCGCCTCGCTTGATCAGCAGTTCGCGCAAGCACTG
AACTCGGCGGCAGCGTCGTATCAGACGGCCGAAGCCACGGGTGCGTCGCTCGTGCAGACCGCGACACAAGGTGTACTGGG
TGTGATCAATGCGCCCACCGAGTTCATGTTCGGACGCTCGCTGATCGGCGACGGAGCTGACGGCACGGCTGCCAGCCCCA
TCGGCGAGCCCGGCGGAATCCTGTACGGCGACGGCGGAAACGGCTACTCCCAGACCACGCCCGGAGCTGTCGGCGGAGCC
GGCGGGTCGGCCGGATTTATCGGTAACGGTGGCGCCGGGGGCGCCGGCGGGCCCGGCGCCGGCGGCGGGACTGGAGGCCT
CGGCGGCTGGTTATGGGGCAACAACGGCGCCGCTGGCACCGGCGACCCAGTTAACGTTGCCGTCCCCCTGCGCGTGGAAA
ACAACTTTCCGCTGGTGAACCTCTTGGTCAACCGCGGGCCAACTGTCCCCATACTGCTGGACACGGGATCCTCGAGTCTC
GTCATCCCATTCTGGAAAATCGGGTGGCAGAACCTGGGCTTGCCCACCGGGTTCGATGTCGTTCACTACGGCAATGGCGT
GAGCATCGTCTACGCCGACGTGCCCACGACGGTCGATTTCGGTGGCGGCGCCGCTACCACACCGACCTCCGTCCATGTCG
GTATCCTGCCGTACCCGCGAAACCTTGACAGCCTGGTCCTCATCGCTTCCGGCGGCGCTTTCGGACCCAACGGAAACGGC
ATACTGGGCATCGGGCCGAATGTGGGGTCGTATGCCGTCAGCGGGCCCGGCAACGTTGTCACGACCGATTTGCCGGGCCA
ACTCAACGAAGGCACCCTCATCGACATTCCCGGCGGCTACATGCAGTTCGGCCCCAACACGGGCACTCCAATCACCTCCG
TGACCGGGGCACCGATCACCGTGCTGAACGTTCAGATCGGCGGCTACGACCCCAACGGGGGCTACTGGTCACTCCCCTCG
ATTTTCGATTCGGGCGGCAACCACGGAACGCTTCCGGCGGTGATTCTCGGCACGGGCCAGACAACCGGTTACGCCCCGCC
GGGCACGGTTATCTCAATCTCAATACATGACAACCAGACGCTGCTGTATCAGTACACGACAACCGCGAGCAACAGCCCAG
TGGTCACGGCAGACCCCCGACTCAACACCGGTCTAACCCCGTTCCTGCTGGGACCGGTATATATCTCGAACAACCCTAGC
GGTGTCGGGACGGTGGTGTTCAATTACCCGCCACCGTAG

Upstream 100 bases:

>100_bases
GGGGATAGCTCGACGAGACAGCCGGGGAAGCCGCAGAAAATTGGGTTGTAGGCGCGTGCAATAGCTACGCTGCATGTGGA
CAGCGGGGAAGAGGTTAGTT

Downstream 100 bases:

>100_bases
CTTTCCGCCGGGTCCAGAACCGCCGCGCCATAAGGGCGTCACGTTCGTCCAGAACCTCGGCTAAGTGCGGAGTGCGCAAT
CATGGTGCACTGCAATGGGT

Product: PE family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MSRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTTLLVAAAEDEVSAAAAALFANYGREYQTLSVRFASLDQQFAQAL
NSAAASYQTAEATGASLVQTATQGVLGVINAPTEFMFGRSLIGDGADGTAASPIGEPGGILYGDGGNGYSQTTPGAVGGA
GGSAGFIGNGGAGGAGGPGAGGGTGGLGGWLWGNNGAAGTGDPVNVAVPLRVENNFPLVNLLVNRGPTVPILLDTGSSSL
VIPFWKIGWQNLGLPTGFDVVHYGNGVSIVYADVPTTVDFGGGAATTPTSVHVGILPYPRNLDSLVLIASGGAFGPNGNG
ILGIGPNVGSYAVSGPGNVVTTDLPGQLNEGTLIDIPGGYMQFGPNTGTPITSVTGAPITVLNVQIGGYDPNGGYWSLPS
IFDSGGNHGTLPAVILGTGQTTGYAPPGTVISISIHDNQTLLYQYTTTASNSPVVTADPRLNTGLTPFLLGPVYISNNPS
GVGTVVFNYPPP

Sequences:

>Translated_492_residues
MSRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTTLLVAAAEDEVSAAAAALFANYGREYQTLSVRFASLDQQFAQAL
NSAAASYQTAEATGASLVQTATQGVLGVINAPTEFMFGRSLIGDGADGTAASPIGEPGGILYGDGGNGYSQTTPGAVGGA
GGSAGFIGNGGAGGAGGPGAGGGTGGLGGWLWGNNGAAGTGDPVNVAVPLRVENNFPLVNLLVNRGPTVPILLDTGSSSL
VIPFWKIGWQNLGLPTGFDVVHYGNGVSIVYADVPTTVDFGGGAATTPTSVHVGILPYPRNLDSLVLIASGGAFGPNGNG
ILGIGPNVGSYAVSGPGNVVTTDLPGQLNEGTLIDIPGGYMQFGPNTGTPITSVTGAPITVLNVQIGGYDPNGGYWSLPS
IFDSGGNHGTLPAVILGTGQTTGYAPPGTVISISIHDNQTLLYQYTTTASNSPVVTADPRLNTGLTPFLLGPVYISNNPS
GVGTVVFNYPPP
>Mature_491_residues
SRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTTLLVAAAEDEVSAAAAALFANYGREYQTLSVRFASLDQQFAQALN
SAAASYQTAEATGASLVQTATQGVLGVINAPTEFMFGRSLIGDGADGTAASPIGEPGGILYGDGGNGYSQTTPGAVGGAG
GSAGFIGNGGAGGAGGPGAGGGTGGLGGWLWGNNGAAGTGDPVNVAVPLRVENNFPLVNLLVNRGPTVPILLDTGSSSLV
IPFWKIGWQNLGLPTGFDVVHYGNGVSIVYADVPTTVDFGGGAATTPTSVHVGILPYPRNLDSLVLIASGGAFGPNGNGI
LGIGPNVGSYAVSGPGNVVTTDLPGQLNEGTLIDIPGGYMQFGPNTGTPITSVTGAPITVLNVQIGGYDPNGGYWSLPSI
FDSGGNHGTLPAVILGTGQTTGYAPPGTVISISIHDNQTLLYQYTTTASNSPVVTADPRLNTGLTPFLLGPVYISNNPSG
VGTVVFNYPPP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PE family. PGRS subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000084 [H]

Pfam domain/function: PF00934 PE [H]

EC number: NA

Molecular weight: Translated: 48785; Mature: 48654

Theoretical pI: Translated: 3.95; Mature: 3.95

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTTLLVAAAEDEVSAAAAALFANYGR
CCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCC
EYQTLSVRFASLDQQFAQALNSAAASYQTAEATGASLVQTATQGVLGVINAPTEFMFGRS
CEEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCEEEEECCCHHHHHCHH
LIGDGADGTAASPIGEPGGILYGDGGNGYSQTTPGAVGGAGGSAGFIGNGGAGGAGGPGA
HCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGGTGGLGGWLWGNNGAAGTGDPVNVAVPLRVENNFPLVNLLVNRGPTVPILLDTGSSSL
CCCCCCCCCEEECCCCCCCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCE
VIPFWKIGWQNLGLPTGFDVVHYGNGVSIVYADVPTTVDFGGGAATTPTSVHVGILPYPR
EEEEEECCCCCCCCCCCCEEEEECCCEEEEEECCCCEEECCCCCCCCCCEEEEEEECCCC
NLDSLVLIASGGAFGPNGNGILGIGPNVGSYAVSGPGNVVTTDLPGQLNEGTLIDIPGGY
CCCEEEEEEECCCCCCCCCEEEEECCCCCCEEECCCCCEEEECCCCCCCCCEEEECCCCC
MQFGPNTGTPITSVTGAPITVLNVQIGGYDPNGGYWSLPSIFDSGGNHGTLPAVILGTGQ
EEECCCCCCCCEEECCCCEEEEEEEECCCCCCCCEEECCHHHCCCCCCCCCEEEEEECCC
TTGYAPPGTVISISIHDNQTLLYQYTTTASNSPVVTADPRLNTGLTPFLLGPVYISNNPS
CCCCCCCCCEEEEEEECCCEEEEEEEECCCCCCEEEECCCCCCCCCCEEEEEEEECCCCC
GVGTVVFNYPPP
CEEEEEEECCCC
>Mature Secondary Structure 
SRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTTLLVAAAEDEVSAAAAALFANYGR
CCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCC
EYQTLSVRFASLDQQFAQALNSAAASYQTAEATGASLVQTATQGVLGVINAPTEFMFGRS
CEEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCEEEEECCCHHHHHCHH
LIGDGADGTAASPIGEPGGILYGDGGNGYSQTTPGAVGGAGGSAGFIGNGGAGGAGGPGA
HCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGGTGGLGGWLWGNNGAAGTGDPVNVAVPLRVENNFPLVNLLVNRGPTVPILLDTGSSSL
CCCCCCCCCEEECCCCCCCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCE
VIPFWKIGWQNLGLPTGFDVVHYGNGVSIVYADVPTTVDFGGGAATTPTSVHVGILPYPR
EEEEEECCCCCCCCCCCCEEEEECCCEEEEEECCCCEEECCCCCCCCCCEEEEEEECCCC
NLDSLVLIASGGAFGPNGNGILGIGPNVGSYAVSGPGNVVTTDLPGQLNEGTLIDIPGGY
CCCEEEEEEECCCCCCCCCEEEEECCCCCCEEECCCCCEEEECCCCCCCCCEEEECCCCC
MQFGPNTGTPITSVTGAPITVLNVQIGGYDPNGGYWSLPSIFDSGGNHGTLPAVILGTGQ
EEECCCCCCCCEEECCCCEEEEEEEECCCCCCCCEEECCHHHCCCCCCCCCEEEEEECCC
TTGYAPPGTVISISIHDNQTLLYQYTTTASNSPVVTADPRLNTGLTPFLLGPVYISNNPS
CCCCCCCCCEEEEEEECCCEEEEEEEECCCCCCEEEECCCCCCCCCCEEEEEEEECCCCC
GVGTVVFNYPPP
CEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]