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The map label for this gene is aceA [H]

Identifier: 148823127

GI number: 148823127

Start: 2168724

End: 2169827

Strand: Direct

Name: aceA [H]

Synonym: TBFG_11944

Alternate gene names: 148823127

Gene position: 2168724-2169827 (Clockwise)

Preceding gene: 148823125

Following gene: 148823128

Centisome position: 49.02

GC content: 65.4

Gene sequence:

>1104_bases
ATGGCCATCGCCGAAACGGACACCGAGGTCCACACACCGTTCGAGCAGGACTTTGAGAAAGACGTAGCCGCCACTCAGCG
ATACTTCGACAGCTCGCGCTTTGCTGGGATCATTCGGCTCTACACCGCCCGCCAAGTCGTGGAACAGCGCGGCACGATCC
CCGTCGACCACATCGTGGCGCGAGAGGCGGCGGGCGCCTTCTACGAGCGTCTGCGCGAACTCTTTGCAGCCCGCAAGAGC
ATCACGACGTTTGGCCCCTACTCGCCGGGGCAGGCGGTGAGCATGAAGCGGATGGGTATCGAGGCGATCTACCTCGGTGG
TTGGGCTACCTCAGCTAAGGGCTCCAGCACCGAAGATCCGGGGCCCGACCTCGCCAGCTACCCGCTGAGCCAGGTGCCTG
ACGATGCCGCGGTGCTGGTGCGCGCCTTGCTCACCGCGGACCGCAACCAACACTATCTACGCCTGCAGATGAGCGAGCGA
CAGCGTGCGGCGACACCGGCTTACGACTTCCGCCCGTTTATCATCGCCGACGCCGGCACCGGCCACGGCGGCGATCCGCA
CGTACGCAACCTGATCCGCCGCTTCGTCGAGGTCGGTGTGCCGGGCTACCACATCGAGGACCAACGACCCGGCACCAAGA
AGTGCGGCCACCAGGGCGGCAAGGTCCTGGTGCCGTCCGACGAACAGATCAAGCGGCTCAACGCCGCCCGCTTCCAGCTC
GACATCATGCGGGTGCCCGGCATCATCGTCGCACGCACCGACGCGGAGGCGGCCAACCTGATCGACAGTCGCGCCGACGA
GCGTGACCAGCCGTTCCTTCTCGGCGCGACCAAGCTCGACGTACCGTCCTACAAGTCCTGTTTCCTGGCAATGGTGCGGC
GTTTTACGAACTGGGCGTCAAGGAGCTCAATGGTCATCTTCTCTATGCGCTTGGCGACAGCGAGTACGCGGCGGCCGGCG
GTTGGCTTGAGCGCCAAGGCATTTTCGGCTTGGTCTCCGACGCGGTCAACGCGTGGCGGGAGGACGGCCAGCAGTCGATC
GACGGCATTTTCGACCAGGTCGAGTCGCGGTTCGTGGCGGCCTGGGAGGACGACGCGGGCCTGA

Upstream 100 bases:

>100_bases
GCGGAATTTGCGAGCCGTCATCGGTCAGTGATCTAGGTCGCCCGTCCGGGGATACACTCGGTCCGTCAGGTGAATCGGGG
CTGCAGAGGAGCGCAAGGCC

Downstream 100 bases:

>100_bases
TGACCTACGGAGAGGCCGTGGCGGACGTGCTCGAATTCGGTCAGAGCGAGGGCGAACCCATTGGCATGGCTCCCGAGGAG
TGGCGGGCGTTCGCCGCGCG

Product: isocitrate lyase aceAa

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKS
ITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSER
QRAATPAYDFRPFIIADAGTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL
DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWASRSSMVIFSMRLATASTRRPA
VGLSAKAFSAWSPTRSTRGGRTASSRSTAFSTRSSRGSWRPGRTTRA

Sequences:

>Translated_367_residues
MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKS
ITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSER
QRAATPAYDFRPFIIADAGTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL
DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWASRSSMVIFSMRLATASTRRPA
VGLSAKAFSAWSPTRSTRGGRTASSRSTAFSTRSSRGSWRPGRTTRA
>Mature_366_residues
AIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKSI
TTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQ
RAATPAYDFRPFIIADAGTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLD
IMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWASRSSMVIFSMRLATASTRRPAV
GLSAKAFSAWSPTRSTRGGRTASSRSTAFSTRSSRGSWRPGRTTRA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=257, Percent_Identity=36.9649805447471, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17561814, Length=241, Percent_Identity=38.5892116182573, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71982926, Length=241, Percent_Identity=38.5892116182573, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320908, Length=270, Percent_Identity=35.9259259259259, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325263, Length=273, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 40490; Mature: 40359

Theoretical pI: Translated: 10.57; Mature: 10.57

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
REAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCEEEEEECCEECCCCCCCCCCC
GPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFRPFIIADAGT
CCCHHHCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHCCCCCCCCCEEEEECCC
GHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEECCCHHHHHHHHHHHHEE
DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWAS
EEEECCCEEEEECCCHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHC
RSSMVIFSMRLATASTRRPAVGLSAKAFSAWSPTRSTRGGRTASSRSTAFSTRSSRGSWR
CCCEEEEEEEHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCC
PGRTTRA
CCCCCCC
>Mature Secondary Structure 
AIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
REAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCEEEEEECCEECCCCCCCCCCC
GPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFRPFIIADAGT
CCCHHHCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHCCCCCCCCCEEEEECCC
GHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEECCCHHHHHHHHHHHHEE
DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWAS
EEEECCCEEEEECCCHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHC
RSSMVIFSMRLATASTRRPAVGLSAKAFSAWSPTRSTRGGRTASSRSTAFSTRSSRGSWR
CCCEEEEEEEHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCC
PGRTTRA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]