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The map label for this gene is aceA [H]

Identifier: 148823128

GI number: 148823128

Start: 2169827

End: 2171023

Strand: Direct

Name: aceA [H]

Synonym: TBFG_11945

Alternate gene names: 148823128

Gene position: 2169827-2171023 (Clockwise)

Preceding gene: 148823127

Following gene: 148823132

Centisome position: 49.04

GC content: 63.99

Gene sequence:

>1197_bases
ATGACCTACGGAGAGGCCGTGGCGGACGTGCTCGAATTCGGTCAGAGCGAGGGCGAACCCATTGGCATGGCTCCCGAGGA
GTGGCGGGCGTTCGCCGCGCGTGCATCGCTGCATGCCGCCCGGGCAAAGGCCAAGGAGCTGGGCGCCGATCCGCCATGGG
ACTGCGAGCTGGCCAAGACCCCGGAGGGCTACTACCAGATCCGCGGCGGCATACCGTATGCGATCGCCAAATCGCTGGCC
GCGGCACCGTTTGCCGACATTCTTTGGATGGAGACCAAGACCGCCGATCTCGCCGACGCTCGACAGTTCGCCGAGGCGAT
CCATGCCGAGTTCCCCGACCAGATGCTGGCGTACAACCTCTCACCATCGTTCAACTGGGACACCACCGGCATGACCGACG
AGGAGATGCGGCGCTTCCCCGAGGAGCTCGGCAAAATGGGCTTCGTCTTCAACTTCATCACCTATGGCGGGCACCAGATC
GACGGTGTCGCGGCCGAGGAATTCGCCACCGCGCTGCGCCAGGACGGCATGCTGGCGCTGGCTCGGTTGCAGCGCAAGAT
GCGCTTGGTCGAATCTCCCTATCGCACACCGCAAACGCTAGTCGGCGGGCCGCGCAGTGACGCCGCATTGGCTGCCTCCT
CCGGACGCACGGCGACCACGAAGGCAATGGGCAAGGGCTCCACCCAGCACCAGCACTTGGTGCAAACTGAGGTGCCGCGC
AAGCTGCTAGAGGAATGGCTGGCCATGTGGAGCGGTCACTACCAGCTCAAAGACAAACTGCGCGTACAGCTTCGGCCGCA
GCGGGCCGGCTCGGAGGTGCTCGAGCTCGGCATCCACGGCGAAAGCGATGACAAGCTCGCCAACGTGATATTCCAACCGA
TCCAAGATCGCCGCGGCCGCACCATCCTGTTGGTACGCGACCAGAACACGTTCGGTGCGGAACTACGCCAAAAGCGGCTG
ATGACCCTGATCCACCTCTGGCTCGTCCACCGCTTCAAGGCGCAGGCGGTGCACTACGTCACGCCCACCGACGACAACCT
CTACCAGACCTCGAAGATGAAGTCGCATGGAATCTTCACCGAGGTCAACCAGGAGGTGGGCGAGATCATCGTCGCCGAGG
TGAACCACCCGCGCATCGCCGAACTGCTGACGCCCGATCGGGTGGCGCTGCGGAAGTTGATCACGAAGGAGGCGTAG

Upstream 100 bases:

>100_bases
GGTCAACGCGTGGCGGGAGGACGGCCAGCAGTCGATCGACGGCATTTTCGACCAGGTCGAGTCGCGGTTCGTGGCGGCCT
GGGAGGACGACGCGGGCCTG

Downstream 100 bases:

>100_bases
CCAGCGCTGCCAACTGTCTTGGGGGCCAACCGGGTGTGCGTCGAGGTGGCGCACATCGCGAAACGCGAAGGATGCTGTCA
GACGGCGTCTGCGGTGGCCT

Product: isocitrate lyase aceAb

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLA
AAPFADILWMETKTADLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQI
DGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPR
KLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRL
MTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA

Sequences:

>Translated_398_residues
MTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLA
AAPFADILWMETKTADLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQI
DGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPR
KLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRL
MTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA
>Mature_397_residues
TYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAA
APFADILWMETKTADLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQID
GVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPRK
LLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRLM
TLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=109, Percent_Identity=46.7889908256881, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17561814, Length=184, Percent_Identity=38.0434782608696, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982926, Length=184, Percent_Identity=38.0434782608696, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320908, Length=195, Percent_Identity=38.974358974359, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325263, Length=182, Percent_Identity=35.1648351648352, Blast_Score=123, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 44582; Mature: 44451

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPPWDCELAKT
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFPDQMLAYNL
CCCCEEEECCCCHHHHHHHHHCCHHHHHEECCCCCHHHHHHHHHHHHHHHCCHHHHEEEC
SPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLAL
CCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCHHHH
ARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPR
HHHHHHHHHHHCCCCCCHHHCCCCCCCCCEECCCCCCHHHHHHCCCCCHHHHHHHHHHHH
KLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGR
HHHHHHHHHHCCCCEECCCEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
TILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFT
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCCHH
EVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA
HHHHHHCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPPWDCELAKT
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFPDQMLAYNL
CCCCEEEECCCCHHHHHHHHHCCHHHHHEECCCCCHHHHHHHHHHHHHHHCCHHHHEEEC
SPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLAL
CCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCHHHH
ARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPR
HHHHHHHHHHHCCCCCCHHHCCCCCCCCCEECCCCCCHHHHHHCCCCCHHHHHHHHHHHH
KLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGR
HHHHHHHHHHCCCCEECCCEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
TILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFT
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCCHH
EVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA
HHHHHHCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]