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The map label for this gene is kstR2

Identifier: 148663420

GI number: 148663420

Start: 4005695

End: 4006297

Strand: Reverse

Name: kstR2

Synonym: MRA_3596

Alternate gene names: 148663420

Gene position: 4006297-4005695 (Counterclockwise)

Preceding gene: 148663422

Following gene: 148663419

Centisome position: 90.64

GC content: 62.35

Gene sequence:

>603_bases
ATGGATCGAGTGGCCGGTCAGGTCAATAGCCGGCGAGGCGAGTTGCTGGAGCTCGCGGCGGCGATGTTCGCCGAGCGCGG
ACTGCGCGCCACCACCGTGCGCGATATCGCCGACGGCGCCGGCATCCTATCCGGCAGCCTGTATCACCATTTCGCCTCCA
AAGAGGAGATGGTCGATGAGCTGTTACGCGGTTTCCTCGATTGGCTCTTCGCCCGTTACCGCGACATCGTGGATAGCACG
GCCAATCCGCTGGAGCGGCTGCAGGGCCTGTTCATGGCGTCGTTTGAGGCGATCGAGCATCATCACGCGCAAGTGGTGAT
CTACCAGGATGAAGCGCAACGGCTGGCGTCGCAACCCAGGTTTTCCTACATCGAGGACCGTAACAAGCAGCAGCGCAAGA
TGTGGGTGGACGTGCTCAACCAGGGCATCGAAGAGGGCTACTTCCGGCCCGACCTAGACGTCGACCTGGTCTACCGATTC
ATCCGTGACACCACCTGGGTGTCGGTGCGCTGGTATCGACCCGGTGGGCCGCTCACCGCCCAGCAGGTGGGCCAGCAATA
CCTAGCCATCGTGCTTGGCGGGATCACCAAAGAGGGAGTCTGA

Upstream 100 bases:

>100_bases
CCGGTGAGCGAAGGGCGCATCCCTCGTACCGAATTCCCGGATTCCCACCCCATCGAGGTCGCAGCTGGCCGAGCAAGCGC
TTGGTTGATAGTCTGGTCGG

Downstream 100 bases:

>100_bases
AATGCCCCGTGTCGACGACGATGCGGTGGGGGTACCACTCACTGGCAACGGGAGAGGAGCGGTTATGACAGAGGCGTACG
TCATCGACGCCGTACGGACC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDST
ANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRF
IRDTTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV

Sequences:

>Translated_200_residues
MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDST
ANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRF
IRDTTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV
>Mature_200_residues
MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDST
ANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRF
IRDTTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV

Specific function: Controls the expression of a small regulon that may play a role in the utilization of cholesterol

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KSTR2_MYCTU (P96839)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842583
- PIR:   C70604
- RefSeq:   NP_218074.1
- RefSeq:   NP_338206.1
- ProteinModelPortal:   P96839
- SMR:   P96839
- EnsemblBacteria:   EBMYCT00000001658
- EnsemblBacteria:   EBMYCT00000071774
- GeneID:   887467
- GeneID:   926545
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3661
- KEGG:   mtu:Rv3557c
- TIGR:   MT3661
- TubercuList:   Rv3557c
- GeneTree:   EBGT00050000014673
- HOGENOM:   HBG754844
- OMA:   PELANHR
- ProtClustDB:   CLSK872200
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647
- Gene3D:   G3DSA:1.10.10.60
- Gene3D:   G3DSA:1.10.357.10
- PRINTS:   PR00455

Pfam domain/function: PF00440 TetR_N; SSF46689 Homeodomain_like; SSF48498 TetR_like_C

EC number: NA

Molecular weight: Translated: 22906; Mature: 22906

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS01081 HTH_TETR_1; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHH
LLRGFLDWLFARYRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCC
FSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVSVRWYRPGGPLTA
HHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCH
QQVGQQYLAIVLGGITKEGV
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHH
LLRGFLDWLFARYRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCC
FSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVSVRWYRPGGPLTA
HHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCH
QQVGQQYLAIVLGGITKEGV
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036