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The map label for this gene is fadD18 [H]

Identifier: 148663376

GI number: 148663376

Start: 3954592

End: 3955248

Strand: Reverse

Name: fadD18 [H]

Synonym: MRA_3552

Alternate gene names: 148663376

Gene position: 3955248-3954592 (Counterclockwise)

Preceding gene: 148663378

Following gene: 148663374

Centisome position: 89.49

GC content: 65.14

Gene sequence:

>657_bases
ATGGCGGCATCTTTAAGTGAGAACCTTAGTTGCCACTCATCTAATATGTGCCGGCTTTCTGGTAATGCCGCAACGAACCT
GGAGCGCCCTGGGGAGGAGCCGCCCGGCGACCGGTGCACCAGGCGCCAAGCAGTGCGACCCGCGCGCACGCTCGCCAAGA
AGGGCAACATTCCCGTCGGCTACTACAAGGACGAGAAGAAGACGGCCGAGACGTTCCGGACGATTAACGGTGTGCGCTAC
GCCATTCCGGGGGACTACGCCCAAGTCGAGGAGGACGGCACGGTCACCATGCTGGGTCGTGGCTCGGTGTCGATCAACAG
CGGCGGCGAGAAGGTCTACCCCGAAGAGGTCGAGGCCGCTTTGAAGGGGCATCCCGACGTGTTCGACGCTCTGGTGGTCG
GGGTGCCCGATCCGCGTTACGGCCAGCAGGTGGCCGCCGTGGTGCAGGCCCGGCCGGGTTGTCGGCCGTCGTTGGCCGAG
TTGGACTCGTTCGTGCGCTCCGAGATCGCGGGCTACAAAGTGCCGCGCAGTCTGTGGTTTGTCGACGAGGTGAAGCGTTC
GCCCGCCGGTAAGCCGGACTACCGCTGGGCCAAGGAGCAGACCGAGGCGCGGCCAGCCGATGACGTGCATGCGGGACACG
TGACGAGCGGTTCCTGA

Upstream 100 bases:

>100_bases
TCAGATCCCCCGCGGCTGCTGTCACGAATTCCGGTGCGATCAACACGAACGACATGGGCGAACTCCCAACCATCTTTGCG
CCGGTGCAACCACGGCCGAT

Downstream 100 bases:

>100_bases
TTGCGCGGGTCGCGGCTATGGCGCCGCGGCTGGGGGATACCGCTGGGTCGCCGTTTGTCGTCAAATCTGGCTGGACCACT
CGCCGGCGGACGCCCGGCGC

Product: fatty-acid-CoA ligase FadD18

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MAASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAVRPARTLAKKGNIPVGYYKDEKKTAETFRTINGVRY
AIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS

Sequences:

>Translated_218_residues
MAASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAVRPARTLAKKGNIPVGYYKDEKKTAETFRTINGVRY
AIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS
>Mature_217_residues
AASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAVRPARTLAKKGNIPVGYYKDEKKTAETFRTINGVRYA
IPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAEL
DSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=168, Percent_Identity=29.1666666666667, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI187761345, Length=134, Percent_Identity=40.2985074626866, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI187761343, Length=134, Percent_Identity=40.2985074626866, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI38505220, Length=163, Percent_Identity=31.9018404907975, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI115511026, Length=161, Percent_Identity=32.9192546583851, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI157311624, Length=171, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI157311622, Length=171, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI58082049, Length=187, Percent_Identity=32.0855614973262, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI42544132, Length=163, Percent_Identity=31.2883435582822, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI122937307, Length=171, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=156, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788107, Length=175, Percent_Identity=30.8571428571429, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786810, Length=146, Percent_Identity=30.8219178082192, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790505, Length=134, Percent_Identity=32.089552238806, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994703, Length=125, Percent_Identity=35.2, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994690, Length=125, Percent_Identity=35.2, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=125, Percent_Identity=35.2, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560308, Length=127, Percent_Identity=37.007874015748, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563687, Length=151, Percent_Identity=32.4503311258278, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=142, Percent_Identity=32.3943661971831, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=124, Percent_Identity=30.6451612903226, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17559526, Length=186, Percent_Identity=30.1075268817204, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=144, Percent_Identity=31.9444444444444, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24581924, Length=160, Percent_Identity=35, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI18859661, Length=166, Percent_Identity=33.1325301204819, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 23631; Mature: 23499

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAVRPARTLAKKGNIPVG
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCE
YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAA
EECCHHHHHHHHHHHCCEEEECCCCHHEECCCCCEEEEECCEEEECCCCCEECHHHHHHH
LKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSLWF
HCCCCCHHHHEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
VDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAVRPARTLAKKGNIPVG
CCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCE
YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAA
EECCHHHHHHHHHHHCCEEEECCCCHHEECCCCCEEEEECCEEEECCCCCEECHHHHHHH
LKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSLWF
HCCCCCHHHHEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
VDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA