| Definition | Mycobacterium tuberculosis H37Ra, complete genome. |
|---|---|
| Accession | NC_009525 |
| Length | 4,419,977 |
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The map label for this gene is hdhA [H]
Identifier: 148663349
GI number: 148663349
Start: 3913299
End: 3914243
Strand: Reverse
Name: hdhA [H]
Synonym: MRA_3525
Alternate gene names: 148663349
Gene position: 3914243-3913299 (Counterclockwise)
Preceding gene: 148663351
Following gene: 148663347
Centisome position: 88.56
GC content: 64.66
Gene sequence:
>945_bases ATGAATTCGCGAGCGCCGCGAAACCTCGCCGTGAGTTCACCTTCGGCGCAAGTGACGGGCCGCATGGTCCAAAATGGCGA GAACCTGTTTCAGTTTCGGCGTGAGGGGCCTCAAGTGCAGCTTTCTTTCCAAGACCGGACCTACCTGGTCACCGGAGGTG GCAGCGGAATCGGCAAGGGGGTGGCCGCCGGGTTGGTCGCGGCTGGAGCCGCCGTCATGATCGTGGGACGAAATCCAGAC AAGCTGGCGGCGGCTGTCAAAGACATCGAGGCGCTCAAGACCGGAGCGATCGGCTATGAGCCGGCCGACATCACCGACGA GGAGCAGACCCTGCGTGTGGTGGACGCGGCAACCGCGTGGCATGGCCGGCTGCACGGTGTGGTGCATTGCGCGGGCGGGT CTCAGACCATTGGGCCAATCACCCAGATCGACTCGCAGGCCTGGCGGCGCACCGTGGACCTCAATGTCAATGGCACCATG TACGTGCTCAAGCACGCCGCGCGGGAATTGGTACGCGGCGGCGGCGGTTCGTTCGTCGGCATCTCCTCGATCGCGGCCAG CAACACCCATCGCTGGTTCGGCGCCTACGGGGTCACCAAGTCGGCCGTTGACCACATGATGAAACTGGCCGCTGACGAAC TCGGCCCGTCGTGGGTACGGGTCAACAGCATCCGCCCGGGCCTGATCCGTACAGATCTGGTTGTGCCCGTCACAGAGTCG CCGGAGCTGAGCGCGGACTACCGGGTCTGCACGCCATTACCGCGGGTGGGTGAGGTCGAAGACGTCGCGAACCTAGCAAT GTTTTTGCTCAGCGACGCGGCCAGTTGGATCACCGGACAGGTCATCAACGTCGACGGCGGCCACATGCTGCGAAGGGGCC CGGACTTCTCGCCCATGCTGGAGCCGGTGTTCGGCGCCGACGGGCTGCGTGGAGTGGTCGGATAA
Upstream 100 bases:
>100_bases CGGCGCACACTGGCCGCAATGTGGCAACAAGCCGCAACCTATGGAATCCCTCCACGATGGCGGCACCGTTGATCACGAAC GTCGAACGTGAACTGAGGGC
Downstream 100 bases:
>100_bases CTTACCTAGTTCACGCAGGGCACGCCGCCGCCATCGATGGGCGCCCCTTGGTCCGGTGTCGGGTCGGTGGTGGTGCCGCC GCCGTACAGCGGATATGTGC
Product: short chain dehydrogenase
Products: NA
Alternate protein names: 7-alpha-HSDH [H]
Number of amino acids: Translated: 314; Mature: 314
Protein sequence:
>314_residues MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQDRTYLVTGGGSGIGKGVAAGLVAAGAAVMIVGRNPD KLAAAVKDIEALKTGAIGYEPADITDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTM YVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSWVRVNSIRPGLIRTDLVVPVTES PELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFSPMLEPVFGADGLRGVVG
Sequences:
>Translated_314_residues MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQDRTYLVTGGGSGIGKGVAAGLVAAGAAVMIVGRNPD KLAAAVKDIEALKTGAIGYEPADITDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTM YVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSWVRVNSIRPGLIRTDLVVPVTES PELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFSPMLEPVFGADGLRGVVG >Mature_314_residues MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQDRTYLVTGGGSGIGKGVAAGLVAAGAAVMIVGRNPD KLAAAVKDIEALKTGAIGYEPADITDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTM YVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSWVRVNSIRPGLIRTDLVVPVTES PELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFSPMLEPVFGADGLRGVVG
Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=32.6612903225806, Blast_Score=114, Evalue=1e-25, Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=29.6875, Blast_Score=105, Evalue=6e-23, Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=31.3492063492063, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI4503301, Length=307, Percent_Identity=30.2931596091205, Blast_Score=99, Evalue=6e-21, Organism=Homo sapiens, GI5031737, Length=275, Percent_Identity=29.8181818181818, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI10190704, Length=266, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI126723750, Length=254, Percent_Identity=29.9212598425197, Blast_Score=92, Evalue=8e-19, Organism=Homo sapiens, GI15277342, Length=267, Percent_Identity=30.7116104868914, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=27.2357723577236, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI4758504, Length=261, Percent_Identity=27.9693486590038, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI33667109, Length=222, Percent_Identity=29.2792792792793, Blast_Score=73, Evalue=4e-13, Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=31.7596566523605, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI126723191, Length=191, Percent_Identity=29.8429319371728, Blast_Score=72, Evalue=7e-13, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=34.5381526104418, Blast_Score=126, Evalue=2e-30, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=27.0916334661355, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=29.8449612403101, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1787526, Length=250, Percent_Identity=28.4, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=29.9595141700405, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=25.2, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=28.4, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1788459, Length=180, Percent_Identity=31.6666666666667, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=28.3464566929134, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=26.5873015873016, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=25.4980079681275, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1787545, Length=248, Percent_Identity=26.6129032258064, Blast_Score=74, Evalue=2e-14, Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=35.4838709677419, Blast_Score=125, Evalue=3e-29, Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=30.2238805970149, Blast_Score=107, Evalue=5e-24, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=30.241935483871, Blast_Score=105, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=29.3172690763052, Blast_Score=104, Evalue=8e-23, Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=29.4339622641509, Blast_Score=101, Evalue=5e-22, Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=28.6245353159851, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=30, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17536651, Length=270, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=30.2238805970149, Blast_Score=94, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=28.9156626506024, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=30.8270676691729, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=28.8973384030418, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17563726, Length=269, Percent_Identity=28.996282527881, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=26.4822134387352, Blast_Score=91, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560332, Length=282, Percent_Identity=29.4326241134752, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562990, Length=267, Percent_Identity=29.5880149812734, Blast_Score=90, Evalue=2e-18, Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=28.4552845528455, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17560220, Length=275, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17559104, Length=279, Percent_Identity=29.0322580645161, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562908, Length=269, Percent_Identity=29.7397769516729, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=28.6274509803922, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17565030, Length=267, Percent_Identity=27.7153558052434, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17561272, Length=233, Percent_Identity=27.0386266094421, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17536025, Length=253, Percent_Identity=27.6679841897233, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI193204405, Length=277, Percent_Identity=26.3537906137184, Blast_Score=78, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17544670, Length=284, Percent_Identity=25.3521126760563, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17538486, Length=275, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=26.5151515151515, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=27.3062730627306, Blast_Score=67, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=280, Percent_Identity=27.8571428571429, Blast_Score=95, Evalue=2e-20, Organism=Saccharomyces cerevisiae, GI6322226, Length=196, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=3e-15, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=36.6533864541833, Blast_Score=123, Evalue=2e-28, Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=36, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=29.9595141700405, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=31.3008130081301, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=30.1587301587302, Blast_Score=101, Evalue=8e-22, Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=29.0836653386454, Blast_Score=95, Evalue=6e-20, Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=28.9795918367347, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI24644337, Length=256, Percent_Identity=29.6875, Blast_Score=78, Evalue=8e-15, Organism=Drosophila melanogaster, GI17737361, Length=264, Percent_Identity=26.8939393939394, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI116007236, Length=233, Percent_Identity=26.6094420600858, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.159 [H]
Molecular weight: Translated: 33194; Mature: 33194
Theoretical pI: Translated: 7.22; Mature: 7.22
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQDRTYLVTGGGSGIGKG CCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHCCCEEEEEECCCEEEEECCCCCCHHH VAAGLVAAGAAVMIVGRNPDKLAAAVKDIEALKTGAIGYEPADITDEEQTLRVVDAATAW HHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEHHHHHHH HGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTMYVLKHAARELVRGGGGSFVG CCCEEEEEEECCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCEEE ISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSWVRVNSIRPGLIRTDLVVPVTES HHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECEEEECCCC PELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFSPML CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHH EPVFGADGLRGVVG HHHHCCCCCCCCCC >Mature Secondary Structure MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQDRTYLVTGGGSGIGKG CCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHCCCEEEEEECCCEEEEECCCCCCHHH VAAGLVAAGAAVMIVGRNPDKLAAAVKDIEALKTGAIGYEPADITDEEQTLRVVDAATAW HHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEHHHHHHH HGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTMYVLKHAARELVRGGGGSFVG CCCEEEEEEECCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCEEE ISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSWVRVNSIRPGLIRTDLVVPVTES HHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECEEEECCCC PELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFSPML CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHH EPVFGADGLRGVVG HHHHCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]