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The map label for this gene is galE [C]

Identifier: 148663332

GI number: 148663332

Start: 3893652

End: 3894746

Strand: Reverse

Name: galE [C]

Synonym: MRA_3508

Alternate gene names: 148663332

Gene position: 3894746-3893652 (Counterclockwise)

Preceding gene: 148663333

Following gene: 148663327

Centisome position: 88.12

GC content: 66.12

Gene sequence:

>1095_bases
GTGGGAACACATGCAGCCACCATGAGAGTCCGCGCCGGCGTGCGGTCCAGTCCGCTGTTGTTGCACGCGGGCACGCCTCC
GACGGCTGCCGCCGCCGAGAGCGGGATGCGTACCCTGGTTACCGGCAGCTCCGGTCACCTGGGCGAGGCGCTGGTGCGCA
CTCTGCGTGCACGGGGCGCCGACATCGTCAGCCTCGACAGCAGACCGTCGCGGTACACGAATATCGTTGGCTGCGTGAGT
GATCGAGCACTGCTGCGAGACGTGATGGCCGGCGTTGAGGTGGTGTTCCACGCGGCCGCCCATCACAAGCCGCAACTGGC
CTTCCTGCCGCGTCAGGCGTTTCTGGACACGAACATCATCGGTACCCAGACCGTGCTGGATGCTGCGGTCGCCGCCAACG
TCCGCGCCTTCGTCATGACATCATCGACGACCGTTTTCGGCGACGCCCTGACACCGCCGGCAGACCAGCCCGCGGCGTGG
ATCGACGAATCCGTCACGCCCATTCCCAAGAACATCTACGGCGTGACCAAAGCTAGCTCCGAGGACCTCTGCCAGTTGGC
ACATCGCAACGACGGTTTGGCCTGCGTCGTGCTGCGTGTTGCCCGATTCTTCGTCGAGGGCGATGACATGCCTGACCTGT
ATGACGGGCGCAGCCAGGACAACATCAAAGCCAACGAATATGCCTGCCGGCGGGTCGCGCTCGAAGACGCGGTAGATGCG
CACCTCAACGCCGCGCAGCGAGCTCCCCAGCTGGGGTTCGGGCGCTATCTGGTGTCGGCGACCACACCGTTTACCCGTGA
TGACCTGACGCAGCTGCGCACCGACGCGGCATCGGTGTTCGCCCGGCGGGTACCGCTGGCCGCGGCTGTGTGGACCCAGC
GTGGTTGGCGCTTCCCCGACCGCCTCGACCGCGTGTACGTTAACTCCCGCGCTCGCCGTGACTTGAACTGGCGTCCGCGG
TTCGACCTAAACGCGGTCGCCGCCAGACTCGCACGCGGGCAGTCGGTGCACACGCCGTTGTCACAACTGGTGGGCTCCAA
GGCATATGCCCACAGCTCCTACCACCGTGGCGTGTTTGCTCCGGCCAGGCCCTGA

Upstream 100 bases:

>100_bases
CGTGTCCCACGTTATTCGGCAGACCGCGAAAAGTCATGCGGGGCAGTGGTTGTCCCCGCAAGACATCGATCGAGTGGTCG
TGGGAATGAGGGCGTGAGTC

Downstream 100 bases:

>100_bases
CGGACTCGGTGTTTATGGTTGTGCGGCGTTGTGGCGTGTGGCTTTGACTGCTGGGGGTCAATCGGGTTTGTCGTCGTCGT
CTTGGTTGTGGAGGAATCGT

Product: dTDP-glucose-4,6-dehydratase-related protein

Products: UDPgalactose

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGADIVSLDSRPSRYTNIVGCVS
DRALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAW
IDESVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNIKANEYACRRVALEDAVDA
HLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFARRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPR
FDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPARP

Sequences:

>Translated_364_residues
MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGADIVSLDSRPSRYTNIVGCVS
DRALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAW
IDESVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNIKANEYACRRVALEDAVDA
HLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFARRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPR
FDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPARP
>Mature_363_residues
GTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGADIVSLDSRPSRYTNIVGCVSD
RALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAWI
DESVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNIKANEYACRRVALEDAVDAH
LNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFARRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPRF
DLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPARP

Specific function: Putative nucleotide sugar epimerase/dehydrogenase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.2

Molecular weight: Translated: 39515; Mature: 39384

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGA
CCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCC
DIVSLDSRPSRYTNIVGCVSDRALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNII
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHCCCCC
GTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKASS
CHHHHHHHHHHHCCEEEEEECCCEEECCCCCCCCCCCHHHHCCCCCCCCCHHCCCCCCCH
EDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNIKANEYACRRVALEDAVDA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
HLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFARRVPLAAAVWTQRGWRFPD
HHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHH
RLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFA
HHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCHHHHCCCCCCCCCC
PARP
CCCC
>Mature Secondary Structure 
GTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGA
CCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCC
DIVSLDSRPSRYTNIVGCVSDRALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNII
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHCCCCC
GTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKASS
CHHHHHHHHHHHCCEEEEEECCCEEECCCCCCCCCCCHHHHCCCCCCCCCHHCCCCCCCH
EDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNIKANEYACRRVALEDAVDA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
HLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFARRVPLAAAVWTQRGWRFPD
HHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHH
RLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFA
HHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCHHHHCCCCCCCCCC
PARP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): 57600 [C]

Specific activity: 233.3

Km value (mM): 0.256 {UDPgalactose}} 0.225 {UDPgalactose}} 0.2 {UDPgalactose}} 0.18 {UDPgalactose}} 0.16 {UDPgalactose}} 0.14 {UDPgalactose}} 0.048 {UDPgalactose}} 0.026 {UDPgalactose}} [C]

Substrates: UDP-glucose

Specific reaction: UDP-glucose = UDP-galactose

General reaction: Epimerization (specificity for carbon forming a hexosulose) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]