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The map label for this gene is PE_PGRS33

Identifier: 148661624

GI number: 148661624

Start: 2071110

End: 2072606

Strand: Reverse

Name: PE_PGRS33

Synonym: MRA_1830

Alternate gene names: 148661624

Gene position: 2072606-2071110 (Counterclockwise)

Preceding gene: 148661625

Following gene: 148661619

Centisome position: 46.89

GC content: 78.16

Gene sequence:

>1497_bases
ATGTCATTTGTGGTCACGATCCCGGAGGCGCTAGCGGCGGTGGCGACCGATTTGGCGGGTATCGGGTCGACGATCGGCAC
CGCCAACGCGGCCGCCGCGGTCCCGACCACGACGGTGTTGGCCGCCGCCGCCGATGAGGTGTCGGCGGCGATGGCGGCAT
TGTTCTCCGGACACGCCCAGGCCTATCAGGCGCTGAGCGCCCAGGCGGCGCTGTTTCACGAGCAGTTCGTGCGGGCGCTC
ACCGCCGGGGCGGGCTCGTATGCGGCCGCCGAGGCCGCCAGCGCGGCCCCGCTAGAGGGTGTGCTCGACGTGATCAACGC
CCCCGCCCTGGCGCTGTTGGGGCGCCCACTGATCGGTAACGGAGCCAACGGGGCCCCGGGGACCGGGGCAAACGGCGGCG
ACGGCGGAATCTTGATCGGCAACGGCGGGGCCGGCGGCTCCGGCGCGGCCGGCATGCCCGGGGGCAACGGCGGAGCCGCT
GGCCTGTTCGGCAACGGCGGGGCCGGCGGCGCCGGGGGGAACGTAGCGTCCGGCACCGCAGGGTTCGGCGGGGCCGGCGG
GGCCGGCGGGCTGCTCTACGGCGCCGGCGGGGCCGGCGGCGCCGGCGGACGCGCCGGTGGTGGGGTGGGCGGTATTGGTG
GGGCCGGCGGGGCCGGCGGCAATGGCGGGCTGCTGTTCGGCGCCGGCGGGGCCGGCGGCGTCGGCGGACTCGCGGCTGAC
GCCGGTGACGGCGGGGCCGGCGGAGACGGCGGGTTGTTCTTCGGCGTGGGCGGTGCCGGCGGGGCCGGCGGCACCGGCAC
TAATGTCACCGGCGGTGCCGGCGGGGCCGGCGGCAATGGCGGGCTCCTGTTCGGCGCCGGCGGGGTGGGCGGTGTTGGCG
GTGACGGTGTGGCATTCCTGGGCACCGCCCCCGGCGGGCCCGGTGGTGCCGGCGGGGCCGGTGGGCTGTTCGGCGTCGGT
GGGGCCGGCGGCGCCGGCGGAATCGGATTGGTCGGGAACGGCGGTGCCGGGGGGTCCGGCGGGTCCGCCCTGCTCTGGGG
CGACGGCGGTGCCGGCGGCGCGGGTGGGGTCGGGTCCACTACCGGCGGTGCCGGCGGGGCGGGCGGCAACGCCGGCCTGC
TGGTAGGCGCCGGCGGGGCCGGCGGCGCCGGCGCACTCGGCGGTGGCGCTACCGGGGTGGGCGGCGCCGGCGGAAACGGC
GGCACTGCGGGCCTGCTGTTTGGTGCCGGCGGCGCCGGCGGATTCGGCTTCGGCGGTGCCGGGGGCGCCGGTGGGCTCGG
CGGCAAAGCCGGGCTGATCGGCGACGGCGGTGACGGCGGCGCCGGAGGAAACGGCACCGGTGCCAAGGGCGGTGACGGCG
GCGCTGGCGGCGGTGCCATCCTGGTCGGCAACGGCGGCAACGGCGGCAACGCCGGGAGTGGCACACCTAACGGCAGCGCG
GGCACCGGCGGTGCCGGCGGGCTGTTGGGTAAGAACGGGATGAACGGGTTACCGTAG

Upstream 100 bases:

>100_bases
TCCGTGATCGCGATACGCTGAATCCGTCGATCTCTGGGGAGTGACCAGGCGATCGGTAGCGGCCCCGCGCCGGGGCCACA
GGGTGTTGACGAGGTGCCAG

Downstream 100 bases:

>100_bases
CCGGGAGGCCGGCTACCGCGCTCCCGGCGTCTTACCTGAAGCCGCGCTGCGACTGTGAATCTCACGACGCCTTGTCGGCG
TGTCGCGTCGCAGGATTCCC

Product: PE-PGRS family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAADEVSAAMAALFSGHAQAYQALSAQAALFHEQFVRAL
TAGAGSYAAAEAASAAPLEGVLDVINAPALALLGRPLIGNGANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAA
GLFGNGGAGGAGGNVASGTAGFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGAGGNGGLLFGAGGAGGVGGLAAD
AGDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGAGGNGGLLFGAGGVGGVGGDGVAFLGTAPGGPGGAGGAGGLFGVG
GAGGAGGIGLVGNGGAGGSGGSALLWGDGGAGGAGGVGSTTGGAGGAGGNAGLLVGAGGAGGAGALGGGATGVGGAGGNG
GTAGLLFGAGGAGGFGFGGAGGAGGLGGKAGLIGDGGDGGAGGNGTGAKGGDGGAGGGAILVGNGGNGGNAGSGTPNGSA
GTGGAGGLLGKNGMNGLP

Sequences:

>Translated_498_residues
MSFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAADEVSAAMAALFSGHAQAYQALSAQAALFHEQFVRAL
TAGAGSYAAAEAASAAPLEGVLDVINAPALALLGRPLIGNGANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAA
GLFGNGGAGGAGGNVASGTAGFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGAGGNGGLLFGAGGAGGVGGLAAD
AGDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGAGGNGGLLFGAGGVGGVGGDGVAFLGTAPGGPGGAGGAGGLFGVG
GAGGAGGIGLVGNGGAGGSGGSALLWGDGGAGGAGGVGSTTGGAGGAGGNAGLLVGAGGAGGAGALGGGATGVGGAGGNG
GTAGLLFGAGGAGGFGFGGAGGAGGLGGKAGLIGDGGDGGAGGNGTGAKGGDGGAGGGAILVGNGGNGGNAGSGTPNGSA
GTGGAGGLLGKNGMNGLP
>Mature_497_residues
SFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAADEVSAAMAALFSGHAQAYQALSAQAALFHEQFVRALT
AGAGSYAAAEAASAAPLEGVLDVINAPALALLGRPLIGNGANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAAG
LFGNGGAGGAGGNVASGTAGFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGAGGNGGLLFGAGGAGGVGGLAADA
GDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGAGGNGGLLFGAGGVGGVGGDGVAFLGTAPGGPGGAGGAGGLFGVGG
AGGAGGIGLVGNGGAGGSGGSALLWGDGGAGGAGGVGSTTGGAGGAGGNAGLLVGAGGAGGAGALGGGATGVGGAGGNGG
TAGLLFGAGGAGGFGFGGAGGAGGLGGKAGLIGDGGDGGAGGNGTGAKGGDGGAGGGAILVGNGGNGGNAGSGTPNGSAG
TGGAGGLLGKNGMNGLP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PE family. PGRS subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PG33_MYCTU (Q50615)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   C70720
- RefSeq:   NP_336325.1
- RefSeq:   YP_177846.1
- ProteinModelPortal:   Q50615
- EnsemblBacteria:   EBMYCT00000001787
- EnsemblBacteria:   EBMYCT00000071889
- GeneID:   885551
- GeneID:   923765
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1866
- KEGG:   mtu:Rv1818c
- TIGR:   MT1866
- TubercuList:   Rv1818c
- GeneTree:   EBGT00070000031790
- HOGENOM:   HBG131163
- OMA:   FHEQFLQ
- ProtClustDB:   CLSK799848
- GO:   GO:0009405
- InterPro:   IPR000084

Pfam domain/function: PF00934 PE

EC number: NA

Molecular weight: Translated: 40756; Mature: 40624

Theoretical pI: Translated: 3.94; Mature: 3.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1e991e8c)-; HASH(0x1e8c7ae0)-; HASH(0x1b94fcac)-; HASH(0x1e4c3894)-; HASH(0x1c10d544)-; HASH(0x1efefee4)-; HASH(0x1e5c6508)-; HASH(0x1edcb5c8)-; HASH(0x1b31d0bc)-; HASH(0x1ea41b9c)-; HASH(0x1df49e2c)-; HASH(0x1efa36c4)-; HASH(0x1f015d88)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAADEVSAAMAALFSGHAQ
CCEEEECHHHHHHHHHHHHHHCCHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYQALSAQAALFHEQFVRALTAGAGSYAAAEAASAAPLEGVLDVINAPALALLGRPLIGN
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCCCCC
GANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAAGLFGNGGAGGAGGNVASGTA
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGAGGNGGLLFGAGGAGGVGGLAAD
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
AGDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGAGGNGGLLFGAGGVGGVGGDGVAFL
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEE
GTAPGGPGGAGGAGGLFGVGGAGGAGGIGLVGNGGAGGSGGSALLWGDGGAGGAGGVGST
ECCCCCCCCCCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCC
TGGAGGAGGNAGLLVGAGGAGGAGALGGGATGVGGAGGNGGTAGLLFGAGGAGGFGFGGA
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
GGAGGLGGKAGLIGDGGDGGAGGNGTGAKGGDGGAGGGAILVGNGGNGGNAGSGTPNGSA
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
GTGGAGGLLGKNGMNGLP
CCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
SFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAADEVSAAMAALFSGHAQ
CEEEECHHHHHHHHHHHHHHCCHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYQALSAQAALFHEQFVRALTAGAGSYAAAEAASAAPLEGVLDVINAPALALLGRPLIGN
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCCCCC
GANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAAGLFGNGGAGGAGGNVASGTA
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGAGGNGGLLFGAGGAGGVGGLAAD
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
AGDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGAGGNGGLLFGAGGVGGVGGDGVAFL
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEE
GTAPGGPGGAGGAGGLFGVGGAGGAGGIGLVGNGGAGGSGGSALLWGDGGAGGAGGVGST
ECCCCCCCCCCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCC
TGGAGGAGGNAGLLVGAGGAGGAGALGGGATGVGGAGGNGGTAGLLFGAGGAGGFGFGGA
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
GGAGGLGGKAGLIGDGGDGGAGGNGTGAKGGDGGAGGGAILVGNGGNGGNAGSGTPNGSA
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
GTGGAGGLLGKNGMNGLP
CCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036