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The map label for this gene is glcD [H]

Identifier: 148661044

GI number: 148661044

Start: 1406027

End: 1407394

Strand: Reverse

Name: glcD [H]

Synonym: MRA_1265

Alternate gene names: 148661044

Gene position: 1407394-1406027 (Counterclockwise)

Preceding gene: 148661045

Following gene: 148661043

Centisome position: 31.84

GC content: 67.84

Gene sequence:

>1368_bases
GTGAATACCGATGTGCTGGCTGGCCTGATGGCCGAGCTGCCCGAGGGGATGGTGGTCACCGACCCCGCCGTCACCGACGG
CTACCGGCAAGACCGGGCCTTTGACCCTTCGGCCGGCAAACCGCTGGCAATCATCCGGCCACGGCGCACCGAAGAGGTGC
AGACGGTGCTGCGTTGGGCCAGTGCGAACCAGGTGCCCGTGGTGACCCGAGGAGCCGGTAGCGGCCTTTCGGGCGGGGCG
ACCGCCCTGGATGGCGGGATCGTGCTGTCCACCGAAAAGATGCGCGACATCACCGTCGACCCGGTCACCCGCACCGCAGT
GTGCCAGCCCGGCCTGTACAACGCCGAGGTGAAGGAGGCCGCCGCCGAACACGGCCTGTGGTATCCCCCGGATCCGTCGT
CGTTCGAGATCTGCAGCATCGGCGGCAACATCGCCACCAACGCCGGCGGGCTGTGCTGCGTGAAGTACGGCGTCACAGGC
GACTACGTACTGGGCATGCAGGTTGTGCTGGCCAACGGCACCGCGGTCCGGCTGGGCGGCCCACGGCTCAAGGACGTCGC
CGGGCTTTCCCTGACCAAACTGTTCGTCGGCAGCGAAGGCACGCTGGGCGTCATCACGGAGGTGACGTTGCGACTGCTGC
CCGCACAGAATGCATCGAGCATCGTGGTGGCCAGCTTCGGCTCGGTGCAGGCGGCGGTCGATGCGGTGCTCGGGGTTACC
GGCCGACTTCGCCCCGCGATGCTGGAGTTCATGGATTCGGTGGCGATCAACGCCGTCGAGGACACCTTGCGGATGGACCT
GGACCGCGATGCGGCGGCCATGCTGGTGGCTGGTTCTGATGAACGTGGCCGCGCGGCCACCGAAGACGCCGCCGTGATGG
CCGCCGTGTTCGCCGAAAACGGTGCGATAGACGTGTTTTCGACCGACGACCCGGATGAGGGCGAGGCGTTCATTGCGGCC
CGGCGGTTCGCCATTCCGGCGGTCGAGAGCAAGGGGGCGTTGCTGCTCGAGGACGTCGGGGTACCGCTGCCCGCACTGGG
CGAACTGGTCACCGGGATTGCGCGCATCGCCGAGGAGCGGAATCTGATGATCTCGGTGATCGCCCACGCCGGGGACGGCA
ATACCCACCCGTTGCTGGTGTACGACCCCGCAGATGCCGCGATGCTAGAGCGCGCCCACCTCGCGTACGGCGAAATCATG
GACCTGGCCGTCGGCCTGGGCGGCACGATCACCGGCGAACACGGCGTGGGCCGGTTGAAACGGCCGTGGTTGGCCGGCTA
TCTCGGGCCCGACGTCCTGGCCCTCAACCAGCGCATCAAGCAAGCGCTGGACCCCCAGGGCATCCTCAATCCCGGCTCGG
CGATCTGA

Upstream 100 bases:

>100_bases
CCATCGTGTGCACCGGGCTGGTCGCGATCCGGCTGCCCGCGCTGCGCGAACTGGATCTGGCGCCCCAAGCGGACATCGAT
CGGCCCGTAGGATCGGCTCA

Downstream 100 bases:

>100_bases
TCCGTCGCGACGTCCCGCCGAGTGTGAACCGCACGACGCGTCCTCGGCGTGTCGCGTCACCAGATTCACAATCGCCGATT
GATATTACCGATGGAATGTC

Product: oxidoreductase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRTEEVQTVLRWASANQVPVVTRGAGSGLSGGA
TALDGGIVLSTEKMRDITVDPVTRTAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTG
DYVLGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNASSIVVASFGSVQAAVDAVLGVT
GRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDERGRAATEDAAVMAAVFAENGAIDVFSTDDPDEGEAFIAA
RRFAIPAVESKGALLLEDVGVPLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEIM
DLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI

Sequences:

>Translated_455_residues
MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRTEEVQTVLRWASANQVPVVTRGAGSGLSGGA
TALDGGIVLSTEKMRDITVDPVTRTAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTG
DYVLGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNASSIVVASFGSVQAAVDAVLGVT
GRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDERGRAATEDAAVMAAVFAENGAIDVFSTDDPDEGEAFIAA
RRFAIPAVESKGALLLEDVGVPLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEIM
DLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI
>Mature_455_residues
MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRTEEVQTVLRWASANQVPVVTRGAGSGLSGGA
TALDGGIVLSTEKMRDITVDPVTRTAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTG
DYVLGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNASSIVVASFGSVQAAVDAVLGVT
GRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDERGRAATEDAAVMAAVFAENGAIDVFSTDDPDEGEAFIAA
RRFAIPAVESKGALLLEDVGVPLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEIM
DLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=438, Percent_Identity=32.648401826484, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI37595754, Length=461, Percent_Identity=31.236442516269, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI119964728, Length=449, Percent_Identity=32.0712694877506, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI4501993, Length=220, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789351, Length=419, Percent_Identity=40.0954653937947, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI48994907, Length=441, Percent_Identity=25.1700680272109, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI48994914, Length=162, Percent_Identity=30.8641975308642, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992373, Length=445, Percent_Identity=31.685393258427, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71992381, Length=445, Percent_Identity=30.3370786516854, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71992392, Length=383, Percent_Identity=31.8537859007833, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17534361, Length=421, Percent_Identity=29.6912114014252, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17556096, Length=472, Percent_Identity=23.9406779661017, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320027, Length=445, Percent_Identity=28.9887640449438, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320023, Length=441, Percent_Identity=28.1179138321995, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320764, Length=475, Percent_Identity=25.8947368421053, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18921117, Length=423, Percent_Identity=28.8416075650118, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24639277, Length=423, Percent_Identity=28.8416075650118, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24639275, Length=423, Percent_Identity=28.8416075650118, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24653753, Length=463, Percent_Identity=24.8380129589633, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 47271; Mature: 47271

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRTEEVQTVLRWA
CCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
SANQVPVVTRGAGSGLSGGATALDGGIVLSTEKMRDITVDPVTRTAVCQPGLYNAEVKEA
CCCCCEEEEECCCCCCCCCCEEECCCEEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHH
AAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTGDYVLGMQVVLANGTAVRLGG
HHHCCCCCCCCCCCEEEEECCCCEECCCCCEEEEEECCCCCEEEEEEEEEECCCEEEECC
PRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNASSIVVASFGSVQAAVDAVLGVT
CCHHHHCCCEEEEEEECCCCCEEHHHHHHHHEECCCCCCEEEEEECCCHHHHHHHHHCCC
GRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDERGRAATEDAAVMAAVFAEN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
GAIDVFSTDDPDEGEAFIAARRFAIPAVESKGALLLEDVGVPLPALGELVTGIARIAEER
CCEEEEECCCCCCCCEEEEEHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHC
NLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEIMDLAVGLGGTITGEHGVGRLK
CEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
RPWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI
CCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRTEEVQTVLRWA
CCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
SANQVPVVTRGAGSGLSGGATALDGGIVLSTEKMRDITVDPVTRTAVCQPGLYNAEVKEA
CCCCCEEEEECCCCCCCCCCEEECCCEEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHH
AAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTGDYVLGMQVVLANGTAVRLGG
HHHCCCCCCCCCCCEEEEECCCCEECCCCCEEEEEECCCCCEEEEEEEEEECCCEEEECC
PRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNASSIVVASFGSVQAAVDAVLGVT
CCHHHHCCCEEEEEEECCCCCEEHHHHHHHHEECCCCCCEEEEEECCCHHHHHHHHHCCC
GRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDERGRAATEDAAVMAAVFAEN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
GAIDVFSTDDPDEGEAFIAARRFAIPAVESKGALLLEDVGVPLPALGELVTGIARIAEER
CCEEEEECCCCCCCCEEEEEHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHC
NLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEIMDLAVGLGGTITGEHGVGRLK
CEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
RPWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI
CCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]