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The map label for this gene is narS

Identifier: 148660622

GI number: 148660622

Start: 942496

End: 943773

Strand: Direct

Name: narS

Synonym: MRA_0853

Alternate gene names: 148660622

Gene position: 942496-943773 (Clockwise)

Preceding gene: 148660620

Following gene: 148660624

Centisome position: 21.32

GC content: 62.75

Gene sequence:

>1278_bases
GTGCCCAGCTACGGCAACCTCGGACGTTTGGGCGGTCGCCATGAGTACGGTGTCCTAGTGGCAATGACCAGCTCGGCGGA
ACTGGACCGGGTTCGTTGGGCGCACCAGTTGCGCTCCTACCGAATTGCTTCGGTATTGCGGATCGGTGTCGTGGGGCTCA
TGGTCGCCGCGATGGTCGTTGGAACCAGCCGGTCCGAATGGCCACAGCAAATCGTGTTGATCGGCGTCTACGCGGTCGCT
GCATTGTGGGCTCTGCTGTTAGCGTATTCGGCGTCCCGGCGATTCTTCGCTTTGCGACGCTTTCGCAGTATGGGCCGGTT
GGAGCCATTTGCTTTCACCGCCGTCGACGTTTTGATATTGACGGGCTTTCAGCTGCTGTCCACCGACGGGATCTATCCGC
TGCTGATCATGATCCTGCTGCCGGTCCTGGTGGGCCTTGACGTGTCGACGCGACGGGCGGCGGTGGTGCTGGCCTGTACG
CTAGTCGGATTCGCAGTCGCGGTGCTGGGAGACCCCGTGATGCTGCGCGCGATTGGATGGCCCGAGACAATATTTCGGTT
CGCGCTCTATGCGTTCCTGTGCGCCACGGCCTTGATGGTGGTTCGCATCGAGGAGCGGCATACCCGTTCGGTTGCCGGCC
TGAGTGCGTTGCGGGCGGAACTGCTTGCCCAGACGATGACGGCCTCGGAGGTGCTGCAGCGGCGGATTGCGGAAGCCATT
CACGATGGACCGCTGCAAGACGTGCTGGCCGCGCGTCAGGAGCTCATCGAGTTGGATGCCGTAACCCCCGGCGACGAGCG
CGTCGGACGCGCGTTGGCCGGACTGCAGAGCGCGTCGGAGCGGCTGCGGCAGGCCACCTTCGAGCTGCATCCGGCAGTGC
TTGAGCAAGTTGGGTTGGGGCCGGCGGTAAAACAGTTGGCGGCCTCTACCGCTCAGCGTTCGGGTATCAAGATCTCCACC
GATATTGATTACCCAATACGTAGTGGGATCGACCCCATCGTTTTCGGTGTGGTTCGCGAACTGCTGTCCAACGTCGTGCG
GCATTCCGGAGCTACCACCGCCTCGGTCAGGCTCGGAATCACCGACGAAAAATGCGTTTTGGATGTGGCCGACGATGGCG
TGGGGGTCACCGGTGACACTATGGCGCGCCGCCTGGGTGAGGGACACATCGGTCTGGCTTCGCATCGGGCTCGGGTGGAT
GCCGCCGGCGGAGTTTTGGTTTTCCTGGCCACCCCCAGGGGGACCCATGTCTGCGTGGAACTACCACTGAAACGGTGA

Upstream 100 bases:

>100_bases
GGCTGCGGATTGCTCATGGCGCGCCGACCATGGCGATGAGTTTAGCTGCTCGTCGGCAACCAGCCGCTGGCAGTCGCTGG
ACATTGATTTGCACTCCGAC

Downstream 100 bases:

>100_bases
ATGGCCGTTGTTGCCGGTCAACCGATGTGCCGGTGGCAGCGACGTGACCCCCGCGCAGGTCGAAAGCCTTGCTGGATCGA
TGGTTCCGCCGGTGCCCGCC

Product: putative two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYAVA
ALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACT
LVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQRRIAEAI
HDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKIST
DIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVD
AAGGVLVFLATPRGTHVCVELPLKR

Sequences:

>Translated_425_residues
MPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYAVA
ALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACT
LVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQRRIAEAI
HDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKIST
DIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVD
AAGGVLVFLATPRGTHVCVELPLKR
>Mature_424_residues
PSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYAVAA
LWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACTL
VGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQRRIAEAIH
DGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKISTD
IDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDA
AGGVLVFLATPRGTHVCVELPLKR

Specific function: Probable member of the two-component regulatory system NarS/NarL. May activate NarL by phosphorylation

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NARS_MYCTU (O53857)

Other databases:

- EMBL:   BX842574
- PIR:   E70813
- RefSeq:   NP_215360.1
- ProteinModelPortal:   O53857
- SMR:   O53857
- EnsemblBacteria:   EBMYCT00000001264
- GeneID:   885218
- GenomeReviews:   AL123456_GR
- KEGG:   mtu:Rv0845
- TubercuList:   Rv0845
- GeneTree:   EBGT00050000014833
- HOGENOM:   HBG565068
- OMA:   PISVAFQ
- ProtClustDB:   CLSK790780
- InterPro:   IPR003594
- InterPro:   IPR005467
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; SSF55874 ATP_bd_ATPase

EC number: =2.7.13.3

Molecular weight: Translated: 45784; Mature: 45653

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d0152e4)-; HASH(0x1d12e5b0)-; HASH(0x1d29f5b0)-; HASH(0x1c4a3f54)-; HASH(0x1bc2d758)-; HASH(0x1d401480)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVV
CCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVDVLIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACTLVGFAVAVLGDPVMLRAIGW
HCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCC
PETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQRRIAEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCC
PAVKQLAASTAQRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGI
HHHHHHHHHHHHHCCCEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
TDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTHVCVE
CCCCEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHEECCCCEEEEEECCCCCEEEEE
LPLKR
ECCCH
>Mature Secondary Structure 
PSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVV
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVDVLIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACTLVGFAVAVLGDPVMLRAIGW
HCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCC
PETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQRRIAEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCC
PAVKQLAASTAQRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGI
HHHHHHHHHHHHHCCCEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
TDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTHVCVE
CCCCEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHEECCCCEEEEEECCCCCEEEEE
LPLKR
ECCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230