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The map label for this gene is argH [H]

Identifier: 148654061

GI number: 148654061

Start: 2826493

End: 2827968

Strand: Direct

Name: argH [H]

Synonym: PsycPRwf_2264

Alternate gene names: 148654061

Gene position: 2826493-2827968 (Clockwise)

Preceding gene: 148654056

Following gene: 148654062

Centisome position: 94.88

GC content: 46.88

Gene sequence:

>1476_bases
ATGACTGCAAATAACGATTCGACCCCTCTTGCAACCGATACAGCCACTACTACTTCTAACGCCAAAGCTGGCAGTGGACA
AGGCCAACAAATGTGGGGCGGCCGCTTCTCTGAGGCTACCGACAGCTTTGTTGCCGCCTTTACCGCCTCAGTAGGCTTTG
ACCAGCGCTTCGCCAAACAAGACATCCAAGGCTCTATCGCTCATGCCACTATGCTGGGTAAATGCGGTATCTTAACGCAA
CAAGAAGTAGACACCATTATCAGTGGTCTACATCAAGTGCAACAAGAAATTGATGCTGGTGAATTTAACTGGTCTATTAC
GCTTGAAGATGTGCACATGAATGTTGAATCTCGCTTGACTGACATTATTGGCACTGTGGGTAAAAAGCTGCACACAGGAC
GCAGCCGTAATGATCAGGTGGCCACTGATATCCGCCTATGGTTACGTCAAGAAGTCGATAATATTGTTGAGTTGTTGGTT
AAATTACAATCAGGTCTACTGACTTTGGCGGAGCAGCACACAGATACCATCATGCCAGGCTTTACCCATTTGCAAACTGC
ACAGCCCGTAAGCTTTGGTCATCATGTATTGGCTTGGTTTGAGATGTTAAATCGTGACACAGAGCGCTTAATTGACGCCC
GTCGCCGTATCAACCAAATGCCTCTGGGTAGCGCCGCACTGGCCGGCACCACCTTCCCTATCGACCGTACCATCACCGCT
GAGCTGTTGGGCTTTGAAGGTATTTGTGAAAATTCACTAGATGCGGTATCTGATAGAGACTTTGCGATTGAATTTACTTC
TGCTGCGTCTATTTTGATGATGCATTTATCGCGCATGAGTGAAGAGATTATTCTGTGGATGTCAGCACAATTTGGCTTTG
TACAAATCCCAGATCGCTTCTGCACCGGCTCATCCATCATGCCGCAAAAGAAAAATCCAGATGTGCCAGAATTAGTGCGT
GGTAAAGCTGCCCGTGTCTTTGGTCAACTCATCACGCTACTGACACTCATGAAAAACCAGCCATTGGCGTACAACAAAGA
CAACCAAGAAGACAAAGAGCCGTTATTTGATTGCGTAGATACCTTAACTGGCTCACTACTTGCATTTGTCGATATGTTGC
CTAATATAGTACCTAATAAGGAAAACATGCGCGCCGCCACCATGAAAGGCTATGCCACAGCCACCGACTTGGCTGACTAC
TTAGTGCGCCGCGGTGTTGCTTTCCGTGATGCCCACGAGGTAGTGGGTAATGCTGTTGCTCTAGGTATTAAACAAGGCGT
GGATTTAAGTGAATTAAAACTTGAGCAATTACAGCAATTTAGTGATGCTATTGGCGATGATGTATTTGATTATCTGACCT
TAGAGGGTTCACTGGCTGCGCGTGACCACTTAGGCGGCACAGCGCCAAACCAAGTCATCCAAGCCGTGGCTCGTGGTCGC
AAACGTCTGGAAAAATACAATAGCAATTTGAAATAA

Upstream 100 bases:

>100_bases
TAAAAACAGCGGCGGCTTAACTAGCATGGCTAGCGTCTGGTTTGCTATACTGCTTTAAGTATTCTAACCGCTTTGTGCCC
TTTACTGGATTTTAACCGAT

Downstream 100 bases:

>100_bases
TCAGTTGATAATTAATAGGATAATACAATGACAGCGACTTTTGACCCAAAAGCCAATATGGTATTTTGCCGTAAGTATCA
GCAGGATTTACCAAAAATGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTANNDSTPLATDTATTTSNAKAGSGQGQQMWGGRFSEATDSFVAAFTASVGFDQRFAKQDIQGSIAHATMLGKCGILTQ
QEVDTIISGLHQVQQEIDAGEFNWSITLEDVHMNVESRLTDIIGTVGKKLHTGRSRNDQVATDIRLWLRQEVDNIVELLV
KLQSGLLTLAEQHTDTIMPGFTHLQTAQPVSFGHHVLAWFEMLNRDTERLIDARRRINQMPLGSAALAGTTFPIDRTITA
ELLGFEGICENSLDAVSDRDFAIEFTSAASILMMHLSRMSEEIILWMSAQFGFVQIPDRFCTGSSIMPQKKNPDVPELVR
GKAARVFGQLITLLTLMKNQPLAYNKDNQEDKEPLFDCVDTLTGSLLAFVDMLPNIVPNKENMRAATMKGYATATDLADY
LVRRGVAFRDAHEVVGNAVALGIKQGVDLSELKLEQLQQFSDAIGDDVFDYLTLEGSLAARDHLGGTAPNQVIQAVARGR
KRLEKYNSNLK

Sequences:

>Translated_491_residues
MTANNDSTPLATDTATTTSNAKAGSGQGQQMWGGRFSEATDSFVAAFTASVGFDQRFAKQDIQGSIAHATMLGKCGILTQ
QEVDTIISGLHQVQQEIDAGEFNWSITLEDVHMNVESRLTDIIGTVGKKLHTGRSRNDQVATDIRLWLRQEVDNIVELLV
KLQSGLLTLAEQHTDTIMPGFTHLQTAQPVSFGHHVLAWFEMLNRDTERLIDARRRINQMPLGSAALAGTTFPIDRTITA
ELLGFEGICENSLDAVSDRDFAIEFTSAASILMMHLSRMSEEIILWMSAQFGFVQIPDRFCTGSSIMPQKKNPDVPELVR
GKAARVFGQLITLLTLMKNQPLAYNKDNQEDKEPLFDCVDTLTGSLLAFVDMLPNIVPNKENMRAATMKGYATATDLADY
LVRRGVAFRDAHEVVGNAVALGIKQGVDLSELKLEQLQQFSDAIGDDVFDYLTLEGSLAARDHLGGTAPNQVIQAVARGR
KRLEKYNSNLK
>Mature_490_residues
TANNDSTPLATDTATTTSNAKAGSGQGQQMWGGRFSEATDSFVAAFTASVGFDQRFAKQDIQGSIAHATMLGKCGILTQQ
EVDTIISGLHQVQQEIDAGEFNWSITLEDVHMNVESRLTDIIGTVGKKLHTGRSRNDQVATDIRLWLRQEVDNIVELLVK
LQSGLLTLAEQHTDTIMPGFTHLQTAQPVSFGHHVLAWFEMLNRDTERLIDARRRINQMPLGSAALAGTTFPIDRTITAE
LLGFEGICENSLDAVSDRDFAIEFTSAASILMMHLSRMSEEIILWMSAQFGFVQIPDRFCTGSSIMPQKKNPDVPELVRG
KAARVFGQLITLLTLMKNQPLAYNKDNQEDKEPLFDCVDTLTGSLLAFVDMLPNIVPNKENMRAATMKGYATATDLADYL
VRRGVAFRDAHEVVGNAVALGIKQGVDLSELKLEQLQQFSDAIGDDVFDYLTLEGSLAARDHLGGTAPNQVIQAVARGRK
RLEKYNSNLK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=455, Percent_Identity=44.1758241758242, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI68303542, Length=455, Percent_Identity=44.1758241758242, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI68303547, Length=443, Percent_Identity=42.8893905191874, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI68303549, Length=455, Percent_Identity=41.3186813186813, Blast_Score=342, Evalue=4e-94,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=47.5770925110132, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17553882, Length=348, Percent_Identity=25, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32565146, Length=315, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=43.5840707964602, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221473854, Length=445, Percent_Identity=38.876404494382, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI78706858, Length=445, Percent_Identity=38.876404494382, Blast_Score=328, Evalue=6e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 54022; Mature: 53891

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANNDSTPLATDTATTTSNAKAGSGQGQQMWGGRFSEATDSFVAAFTASVGFDQRFAKQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
DIQGSIAHATMLGKCGILTQQEVDTIISGLHQVQQEIDAGEFNWSITLEDVHMNVESRLT
HHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCHHHHHH
DIIGTVGKKLHTGRSRNDQVATDIRLWLRQEVDNIVELLVKLQSGLLTLAEQHTDTIMPG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTHLQTAQPVSFGHHVLAWFEMLNRDTERLIDARRRINQMPLGSAALAGTTFPIDRTITA
CHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCHHHH
ELLGFEGICENSLDAVSDRDFAIEFTSAASILMMHLSRMSEEIILWMSAQFGFVQIPDRF
HHHCCHHHCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCHHH
CTGSSIMPQKKNPDVPELVRGKAARVFGQLITLLTLMKNQPLAYNKDNQEDKEPLFDCVD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
TLTGSLLAFVDMLPNIVPNKENMRAATMKGYATATDLADYLVRRGVAFRDAHEVVGNAVA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGIKQGVDLSELKLEQLQQFSDAIGDDVFDYLTLEGSLAARDHLGGTAPNQVIQAVARGR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHH
KRLEKYNSNLK
HHHHHHCCCCC
>Mature Secondary Structure 
TANNDSTPLATDTATTTSNAKAGSGQGQQMWGGRFSEATDSFVAAFTASVGFDQRFAKQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
DIQGSIAHATMLGKCGILTQQEVDTIISGLHQVQQEIDAGEFNWSITLEDVHMNVESRLT
HHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCHHHHHH
DIIGTVGKKLHTGRSRNDQVATDIRLWLRQEVDNIVELLVKLQSGLLTLAEQHTDTIMPG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTHLQTAQPVSFGHHVLAWFEMLNRDTERLIDARRRINQMPLGSAALAGTTFPIDRTITA
CHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCHHHH
ELLGFEGICENSLDAVSDRDFAIEFTSAASILMMHLSRMSEEIILWMSAQFGFVQIPDRF
HHHCCHHHCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCHHH
CTGSSIMPQKKNPDVPELVRGKAARVFGQLITLLTLMKNQPLAYNKDNQEDKEPLFDCVD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
TLTGSLLAFVDMLPNIVPNKENMRAATMKGYATATDLADYLVRRGVAFRDAHEVVGNAVA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGIKQGVDLSELKLEQLQQFSDAIGDDVFDYLTLEGSLAARDHLGGTAPNQVIQAVARGR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHH
KRLEKYNSNLK
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA