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The map label for this gene is upp [H]

Identifier: 148654056

GI number: 148654056

Start: 2822266

End: 2822904

Strand: Direct

Name: upp [H]

Synonym: PsycPRwf_2259

Alternate gene names: 148654056

Gene position: 2822266-2822904 (Clockwise)

Preceding gene: 148654054

Following gene: 148654061

Centisome position: 94.74

GC content: 43.82

Gene sequence:

>639_bases
ATGAACAATTTAAACATAGAAATTATTAAACACCCTTTAGTGCGCCACAAGCTGAGCTTAATGCGTGCCAAAGACTGTAG
TACTTATAAATTCCGCACCTTAACCAGCGAACTTGCTCGCTTAATGGCCTATGAAGCGTGCCGTGACTTTGAAATCGAAG
AATTCGCTATGCAGGGCTGGGATAATACAGAGATTACCGGTGAGCAAATTGTTGGTAAAACTGTGACAATCGTACCTATT
CTACGTGCCGGCCTTGGTATGTTAGATGGTGTGCTCGACTTAATCCCGACTGCCAAAATCTCTATGGTGGGTTTGCAGCG
TGATGAAGAGACGCTACAGCCTGTACCATTTTTTGAAAAGCTAGTGGCTGATGTCGATAAGCGTCCTGCGCTGATTATCG
ATCCGATGTTGGCTACTGGTGGCTCGATGGTAGCTACTATTGATATGCTTAAGAAAAAAGGCTGCTCTACGATTAAGGCA
TTAGTATTGGTTGCAGCGCCTGAAGGCGTACGTTTGGTAAACGAAGCGCACCCAGATGTGAAGATTTATACCGCCTCTTT
AGACAGTCACTTAAATGAAGATGGCTATATCATTCCAGGTCTTGGCGATGCAGGTGATAAGATTTTTGGTACTAAATAA

Upstream 100 bases:

>100_bases
CATTTTTTTATCCAATTTATATTGTCACCTGTATCCCCTTGATACTCTCCCCTAAATTCAAGCCCGCTGTTCCCACACAG
ACGATGCTCAAAGAGGTTTT

Downstream 100 bases:

>100_bases
GTGTTTATGACCAACCATCAAAAGCTATCGAGTCATTAGCCATAACTCGCTATTTGCCATAACCAACTACTGGCGATAAT
GACCCAATAATCATAGCAAG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNNLNIEIIKHPLVRHKLSLMRAKDCSTYKFRTLTSELARLMAYEACRDFEIEEFAMQGWDNTEITGEQIVGKTVTIVPI
LRAGLGMLDGVLDLIPTAKISMVGLQRDEETLQPVPFFEKLVADVDKRPALIIDPMLATGGSMVATIDMLKKKGCSTIKA
LVLVAAPEGVRLVNEAHPDVKIYTASLDSHLNEDGYIIPGLGDAGDKIFGTK

Sequences:

>Translated_212_residues
MNNLNIEIIKHPLVRHKLSLMRAKDCSTYKFRTLTSELARLMAYEACRDFEIEEFAMQGWDNTEITGEQIVGKTVTIVPI
LRAGLGMLDGVLDLIPTAKISMVGLQRDEETLQPVPFFEKLVADVDKRPALIIDPMLATGGSMVATIDMLKKKGCSTIKA
LVLVAAPEGVRLVNEAHPDVKIYTASLDSHLNEDGYIIPGLGDAGDKIFGTK
>Mature_212_residues
MNNLNIEIIKHPLVRHKLSLMRAKDCSTYKFRTLTSELARLMAYEACRDFEIEEFAMQGWDNTEITGEQIVGKTVTIVPI
LRAGLGMLDGVLDLIPTAKISMVGLQRDEETLQPVPFFEKLVADVDKRPALIIDPMLATGGSMVATIDMLKKKGCSTIKA
LVLVAAPEGVRLVNEAHPDVKIYTASLDSHLNEDGYIIPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=28.2178217821782, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=28.2178217821782, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI87082118, Length=204, Percent_Identity=64.7058823529412, Blast_Score=285, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17539892, Length=219, Percent_Identity=25.5707762557078, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=219, Percent_Identity=25.5707762557078, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=34.1968911917098, Blast_Score=119, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=27.0935960591133, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=27.0935960591133, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=27.0935960591133, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=27.0935960591133, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23283; Mature: 23283

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLNIEIIKHPLVRHKLSLMRAKDCSTYKFRTLTSELARLMAYEACRDFEIEEFAMQGW
CCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
DNTEITGEQIVGKTVTIVPILRAGLGMLDGVLDLIPTAKISMVGLQRDEETLQPVPFFEK
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCHHHH
LVADVDKRPALIIDPMLATGGSMVATIDMLKKKGCSTIKALVLVAAPEGVRLVNEAHPDV
HHHCCCCCCEEEECCHHHCCCCHHHHHHHHHHCCCHHHHHHHEEECCCCCEEHHCCCCCE
KIYTASLDSHLNEDGYIIPGLGDAGDKIFGTK
EEEEEEHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MNNLNIEIIKHPLVRHKLSLMRAKDCSTYKFRTLTSELARLMAYEACRDFEIEEFAMQGW
CCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
DNTEITGEQIVGKTVTIVPILRAGLGMLDGVLDLIPTAKISMVGLQRDEETLQPVPFFEK
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCHHHH
LVADVDKRPALIIDPMLATGGSMVATIDMLKKKGCSTIKALVLVAAPEGVRLVNEAHPDV
HHHCCCCCCEEEECCHHHCCCCHHHHHHHHHHCCCHHHHHHHEEECCCCCEEHHCCCCCE
KIYTASLDSHLNEDGYIIPGLGDAGDKIFGTK
EEEEEEHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA