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The map label for this gene is prlC [H]

Identifier: 148654037

GI number: 148654037

Start: 2783776

End: 2785914

Strand: Direct

Name: prlC [H]

Synonym: PsycPRwf_2240

Alternate gene names: 148654037

Gene position: 2783776-2785914 (Clockwise)

Preceding gene: 148654034

Following gene: 148654038

Centisome position: 93.45

GC content: 47.27

Gene sequence:

>2139_bases
ATGCACCCTACCTCTTATACCAAAGATATTGATCCAAATTTACATCTGGTCAACTTCTCTGAAGTTACCCCAGAGCAGCT
CAAAAAGCAGGTAACTGATGCTTTAGCGAAAGGCACCGCTTTTTTGGATAAATTAGATACGCAGCACAGTGCACCGGCTG
AAGCTCAGCAGGCTTTGGATGATATTATCGAGTTTGACCATATTGGCCTAGACTTAGACCGCAGTTGGGGTATTTTGTCT
CATCTTAATAGCGTGATGAGTAATGAGGATATCCGTGATGTGCATCATGACTTGCTGCCTGCCCTCTCCGCCTTTGGTAC
CCGTGTGGGTCAAAACAAACCTCTATATAGCCGCTATCAAACCATCAAAAATGACAGCGCATTCTTTGCAAGCTTAGAGC
CTGCGCGCAAGCGTGCTATTGAGCTTGCTATTCAAAGCTTTGAGCTGTCTGGTATTGGCCTAGCTGCCGAAGAGCAGGCC
CGTTATGCTGATATTCAAAGCCAGTTATCGACCTTATCTGCTAAGTTCTCAGACAATATTTTGGATGCCACACAGGCCTT
TGCGCTACCTTTAAGCAATGAGCAGCTTGCCGGCATTACCGAAAGTGGTCTTGCCATGCTCAAAGCAGCAGCTGAGCAGT
ATATTGCCAAGCAAGACGCCGACCCGTCGATGCAAGATAAGCCTGAGTATGTGGCTACCCTAGATATCCCAGTGTATCTG
GCTGTGATGACTCATGCTGAGGATCGTAAGCTGCGCGAAATATTATACAAAGCGTATGTCACTCGTGCCTCACAGTTTGA
TAGCCACACAAACGCCAAACAAGAGACGCTGGATAACAGCGATATCATGGCGCAGATATTGCAGTTGCGCACTCAAAAAG
CACAGCTTTTGGGCTTTGACAACTATGCTGAAGTCTCCTTATCACGCAAGATGGCAGACAGTGCTGAGCAAGTAGAGCGC
TTCTTACGTGACTTGGCCAGCAAAGCTATGCCTGCTGCCGAGACTGATTTAGCACAGTTACAAGCAGAAGCTGCTAAGCT
GGGCATCGAGCAGATTCAGCCTTGGGATACTGCCTACTTGGCCGAAAAAGTAAAACAGGCCAAATTCAACTTATCACAAG
AAGAAATCCGTCCTTATTTCCCTCTGCCTAAAGTGATTGAAGGGCTATTTACCATTGTCAACAAGCTGTTTGGGGTACGT
GCCATAGAGCAGTCTGACAAAGTGGCACTGTGGCATAAAGATGTGCGCTTTTATGAGCTGTTTGATAAAGATGACAGTTT
AATTGGCGGTTTCTACTTCGATTTATATGCTCGCAGCGGTAAACGTGGCGGTGCTTGGATGAGCGGTTTTCAGGCCCGTT
ATGAGTATACTGGCAGTACACATGATGCTTATAGCCAACTGCCTGTGTGCTTTATGGTGGGTAATTTCACACCGCCAACT
GCCGATAAGCCAAGTTTATTGACCCATGATGAAGTACTGACCTTATTCCATGAGTTTGGACATGGCCTGCATCATTTATT
AACCCAAGTGAGCGTTAGTGATGTGGCCGGCGTCAATGGCGTTGAATGGGATGCTGTGGAGTTGCCCAGTCAGTTCTTAG
AGAACTGGGCTTGGCATTCAGAGGGTATCGCACTTATTAGTGCGCATGTTGACACTGGTGAGGCGCTACCAAAAGAGCAG
CTTGAGGCACTATTGGCAGCCAAAAACTTCCAAAGCGGTATGCAGACCTTACGTCAAATTGAATTTGCTTTATTTGATTT
GCTCATCCATGCCCAATCACCGGCACCCGATTATCAGAACATTTTAGCGACTTTAAATGGTGTGCGTGATGATATTGCCA
TCCTAGATACCCCCGATTACAACCGCTTTGCCAATGGCTTTAGTCATATCTTCGCTGGGGGCTATGCGGCAGGTTACTAC
TCTTATAAATGGGCAGAGCTATTGTCCGCGGATGCCTTTAGCCGCTTTGAGGAAGAGGGGATTTTTAATGCAGACACAGG
TCAATCTTTCCGCGAGAATATCTTAGCGGTAGGCGGCAGCTTGCCTGCCAAGACCAACTTTGAAGCCTTTAGAGGCCGTG
AAGCCAGCATTGAGGCACTACTGCGTCATGGCGGCTTTATAGATGACGAGGTGGCCTAA

Upstream 100 bases:

>100_bases
TTTAGCCGGCTGTTATCCAACTGTTATGTAGCTAGCCGGTATTTAAATTAATATCCCTTTTATTACTGTCCATTCGCTTG
TTAGCTTTAGGAATTCATTT

Downstream 100 bases:

>100_bases
GATGCGCTATCAATCTACTCGCCCTAAGCGTCAGTTCTTAGCCGGTGTCAGCTGTCCAAAATGTCAGACCATGGATGCTG
TGGTACAGGTTCGGGTGTTT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 712; Mature: 712

Protein sequence:

>712_residues
MHPTSYTKDIDPNLHLVNFSEVTPEQLKKQVTDALAKGTAFLDKLDTQHSAPAEAQQALDDIIEFDHIGLDLDRSWGILS
HLNSVMSNEDIRDVHHDLLPALSAFGTRVGQNKPLYSRYQTIKNDSAFFASLEPARKRAIELAIQSFELSGIGLAAEEQA
RYADIQSQLSTLSAKFSDNILDATQAFALPLSNEQLAGITESGLAMLKAAAEQYIAKQDADPSMQDKPEYVATLDIPVYL
AVMTHAEDRKLREILYKAYVTRASQFDSHTNAKQETLDNSDIMAQILQLRTQKAQLLGFDNYAEVSLSRKMADSAEQVER
FLRDLASKAMPAAETDLAQLQAEAAKLGIEQIQPWDTAYLAEKVKQAKFNLSQEEIRPYFPLPKVIEGLFTIVNKLFGVR
AIEQSDKVALWHKDVRFYELFDKDDSLIGGFYFDLYARSGKRGGAWMSGFQARYEYTGSTHDAYSQLPVCFMVGNFTPPT
ADKPSLLTHDEVLTLFHEFGHGLHHLLTQVSVSDVAGVNGVEWDAVELPSQFLENWAWHSEGIALISAHVDTGEALPKEQ
LEALLAAKNFQSGMQTLRQIEFALFDLLIHAQSPAPDYQNILATLNGVRDDIAILDTPDYNRFANGFSHIFAGGYAAGYY
SYKWAELLSADAFSRFEEEGIFNADTGQSFRENILAVGGSLPAKTNFEAFRGREASIEALLRHGGFIDDEVA

Sequences:

>Translated_712_residues
MHPTSYTKDIDPNLHLVNFSEVTPEQLKKQVTDALAKGTAFLDKLDTQHSAPAEAQQALDDIIEFDHIGLDLDRSWGILS
HLNSVMSNEDIRDVHHDLLPALSAFGTRVGQNKPLYSRYQTIKNDSAFFASLEPARKRAIELAIQSFELSGIGLAAEEQA
RYADIQSQLSTLSAKFSDNILDATQAFALPLSNEQLAGITESGLAMLKAAAEQYIAKQDADPSMQDKPEYVATLDIPVYL
AVMTHAEDRKLREILYKAYVTRASQFDSHTNAKQETLDNSDIMAQILQLRTQKAQLLGFDNYAEVSLSRKMADSAEQVER
FLRDLASKAMPAAETDLAQLQAEAAKLGIEQIQPWDTAYLAEKVKQAKFNLSQEEIRPYFPLPKVIEGLFTIVNKLFGVR
AIEQSDKVALWHKDVRFYELFDKDDSLIGGFYFDLYARSGKRGGAWMSGFQARYEYTGSTHDAYSQLPVCFMVGNFTPPT
ADKPSLLTHDEVLTLFHEFGHGLHHLLTQVSVSDVAGVNGVEWDAVELPSQFLENWAWHSEGIALISAHVDTGEALPKEQ
LEALLAAKNFQSGMQTLRQIEFALFDLLIHAQSPAPDYQNILATLNGVRDDIAILDTPDYNRFANGFSHIFAGGYAAGYY
SYKWAELLSADAFSRFEEEGIFNADTGQSFRENILAVGGSLPAKTNFEAFRGREASIEALLRHGGFIDDEVA
>Mature_712_residues
MHPTSYTKDIDPNLHLVNFSEVTPEQLKKQVTDALAKGTAFLDKLDTQHSAPAEAQQALDDIIEFDHIGLDLDRSWGILS
HLNSVMSNEDIRDVHHDLLPALSAFGTRVGQNKPLYSRYQTIKNDSAFFASLEPARKRAIELAIQSFELSGIGLAAEEQA
RYADIQSQLSTLSAKFSDNILDATQAFALPLSNEQLAGITESGLAMLKAAAEQYIAKQDADPSMQDKPEYVATLDIPVYL
AVMTHAEDRKLREILYKAYVTRASQFDSHTNAKQETLDNSDIMAQILQLRTQKAQLLGFDNYAEVSLSRKMADSAEQVER
FLRDLASKAMPAAETDLAQLQAEAAKLGIEQIQPWDTAYLAEKVKQAKFNLSQEEIRPYFPLPKVIEGLFTIVNKLFGVR
AIEQSDKVALWHKDVRFYELFDKDDSLIGGFYFDLYARSGKRGGAWMSGFQARYEYTGSTHDAYSQLPVCFMVGNFTPPT
ADKPSLLTHDEVLTLFHEFGHGLHHLLTQVSVSDVAGVNGVEWDAVELPSQFLENWAWHSEGIALISAHVDTGEALPKEQ
LEALLAAKNFQSGMQTLRQIEFALFDLLIHAQSPAPDYQNILATLNGVRDDIAILDTPDYNRFANGFSHIFAGGYAAGYY
SYKWAELLSADAFSRFEEEGIFNADTGQSFRENILAVGGSLPAKTNFEAFRGREASIEALLRHGGFIDDEVA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=702, Percent_Identity=31.3390313390313, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI14149738, Length=701, Percent_Identity=30.0998573466476, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI156105687, Length=705, Percent_Identity=22.8368794326241, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1789913, Length=694, Percent_Identity=47.4063400576369, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI1787819, Length=657, Percent_Identity=31.0502283105023, Blast_Score=278, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71999758, Length=471, Percent_Identity=25.6900212314225, Blast_Score=115, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32565901, Length=655, Percent_Identity=21.2213740458015, Blast_Score=109, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319793, Length=646, Percent_Identity=31.8885448916409, Blast_Score=290, Evalue=7e-79,
Organism=Saccharomyces cerevisiae, GI6322715, Length=703, Percent_Identity=23.0440967283073, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21356111, Length=654, Percent_Identity=27.9816513761468, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI20129717, Length=605, Percent_Identity=25.6198347107438, Blast_Score=168, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 79220; Mature: 79220

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPTSYTKDIDPNLHLVNFSEVTPEQLKKQVTDALAKGTAFLDKLDTQHSAPAEAQQALD
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
DIIEFDHIGLDLDRSWGILSHLNSVMSNEDIRDVHHDLLPALSAFGTRVGQNKPLYSRYQ
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
TIKNDSAFFASLEPARKRAIELAIQSFELSGIGLAAEEQARYADIQSQLSTLSAKFSDNI
HHCCCCHHEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
LDATQAFALPLSNEQLAGITESGLAMLKAAAEQYIAKQDADPSMQDKPEYVATLDIPVYL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHH
AVMTHAEDRKLREILYKAYVTRASQFDSHTNAKQETLDNSDIMAQILQLRTQKAQLLGFD
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
NYAEVSLSRKMADSAEQVERFLRDLASKAMPAAETDLAQLQAEAAKLGIEQIQPWDTAYL
CHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
AEKVKQAKFNLSQEEIRPYFPLPKVIEGLFTIVNKLFGVRAIEQSDKVALWHKDVRFYEL
HHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCEEEE
FDKDDSLIGGFYFDLYARSGKRGGAWMSGFQARYEYTGSTHDAYSQLPVCFMVGNFTPPT
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCHHHHHCCEEEEECCCCCCC
ADKPSLLTHDEVLTLFHEFGHGLHHLLTQVSVSDVAGVNGVEWDAVELPSQFLENWAWHS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
EGIALISAHVDTGEALPKEQLEALLAAKNFQSGMQTLRQIEFALFDLLIHAQSPAPDYQN
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ILATLNGVRDDIAILDTPDYNRFANGFSHIFAGGYAAGYYSYKWAELLSADAFSRFEEEG
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IFNADTGQSFRENILAVGGSLPAKTNFEAFRGREASIEALLRHGGFIDDEVA
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHPTSYTKDIDPNLHLVNFSEVTPEQLKKQVTDALAKGTAFLDKLDTQHSAPAEAQQALD
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
DIIEFDHIGLDLDRSWGILSHLNSVMSNEDIRDVHHDLLPALSAFGTRVGQNKPLYSRYQ
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
TIKNDSAFFASLEPARKRAIELAIQSFELSGIGLAAEEQARYADIQSQLSTLSAKFSDNI
HHCCCCHHEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
LDATQAFALPLSNEQLAGITESGLAMLKAAAEQYIAKQDADPSMQDKPEYVATLDIPVYL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHH
AVMTHAEDRKLREILYKAYVTRASQFDSHTNAKQETLDNSDIMAQILQLRTQKAQLLGFD
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
NYAEVSLSRKMADSAEQVERFLRDLASKAMPAAETDLAQLQAEAAKLGIEQIQPWDTAYL
CHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
AEKVKQAKFNLSQEEIRPYFPLPKVIEGLFTIVNKLFGVRAIEQSDKVALWHKDVRFYEL
HHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCEEEE
FDKDDSLIGGFYFDLYARSGKRGGAWMSGFQARYEYTGSTHDAYSQLPVCFMVGNFTPPT
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCHHHHHCCEEEEECCCCCCC
ADKPSLLTHDEVLTLFHEFGHGLHHLLTQVSVSDVAGVNGVEWDAVELPSQFLENWAWHS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
EGIALISAHVDTGEALPKEQLEALLAAKNFQSGMQTLRQIEFALFDLLIHAQSPAPDYQN
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ILATLNGVRDDIAILDTPDYNRFANGFSHIFAGGYAAGYYSYKWAELLSADAFSRFEEEG
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IFNADTGQSFRENILAVGGSLPAKTNFEAFRGREASIEALLRHGGFIDDEVA
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]